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Sensory nerve action potential amplitudes decreased as patients aged in a cohort of spinal muscular atrophy (SMA) type 1 patients compared with a healthy, age-matched control group.

Ian J. Neeland, MD, FACC, FAHA, is co-director of the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease for University Hospitals Harrington Heart & Vascular Institute and director of the UH Center for Cardiovascular Prevention, in the Cleveland, Ohio, area. Here, he explains how sodium-glucose co-transporter 2 (SGLT2) inhibitors can treat metabolic physiologic effects of sleep apnea.

Use of biologics and age may influence risk of psoriatic arthritis (PsA) development in patients with psoriasis, according to findings presented at the 2021 American College of Rheumatology Annual Meeting.

The study showed children with thalassemia had a greater risk of both atopic and non-atopic asthma.

Five gene hubs were identified, with one in particular appearing to correlate strongly with the pathogenesis of lupus nephritis.

Robert J. Hopkin, MD, clinical geneticist, Cincinnati Children's Hospital Medical Center, details various known and understudied health-related quality-of-life factors in patients with Fabry disease.

Better risk stratification can help prioritize patients with hepatocellular carcinoma on the transplant waitlist who have higher risk disease.

Results of a prospective study revealed several endothelial markers are associated with kidney dysfunction among children with type 1 diabetes.

Investigators anticipate the results will help physicians tailor treatment methods for patients with chronic obstructive pulmonary disease (COPD) and help to better understand the demographic and clinical implications on peak inspiratory flow.

Researchers in Iran sought to quantify headaches related to personal protective equipment (PPE) among frontline health care workers.

The case required significant testing to get to the correct diagnosis, but the investigators hope their experience helps inform doctors facing similar cases in the future.

In Icelandic patients, obstructive sleep apnea were associated with a 2-fold increased risk of severe COVID-19 that required hospitalization or led to death after accounting for obesity and other comorbidities.

This study from Japan investigated the impact of early initiation of growth hormone (GH) treatment on puberty onset and adult height outcome.

All-trans retinoic acid and arsenic trioxide used together can let children avoid treatment with convention chemotherapy, which has more adverse effects.

Despite a relatively low response rate to acid suppression therapy to treat chronic cough, heartburn was a highly significant predictor of success.

The report briefly explained the policy options that policymakers can use to help address challenges related to vaccine research and development, testing, and manufacturing, as well as the economic challenges related to vaccine development for infectious diseases.

Body mass index (BMI) was not identified as a factor influencing cognitive function or brain mass in patients with relapsing-remitting multiple sclerosis (RRMS), investigators of a recent analysis concluded.

A federal jury in Cleveland found CVS, Walgreens, and Walmart pharmacies responsible for contributing to the opioid crisis; concerns rise after the death of a woman who received infusions of the Alzheimer disease drug Aduhelm; Juul vowed to stop advertising its vaping products to young people in Arizona.

Improving clinical care is only one element of the 360-degree, holistic treatment that is necessary to achieve patient equity, not equality, in patients with chronic kidney disease. Biology, lifestyle, and socioeconomic status are 3 areas in which inequities often have a particularly negative impact on a carefully constructed care plan.

The recommendations come at a time when treatments for chronic lymphocytic leukemia (CLL), such as venetoclax, are making deep remissions and undetectable minimal residual disease (MRD) after a fixed duration of treatment feasible goals.

The data set included 177 samples from polycythemia vera, essential thrombocytopenia, primary myelofibrosis, and healthy donors, from which the researchers found that MAPK14 was overexpressed in PV samples and was associated with more symptoms and worse outcomes.

Daniel Wolfson, executive vice president and chief operating officer of the ABIM Foundation, speaks on factors influencing mistrust of the health care system and efforts to improve quality care.

A recent study aims to improve evaluation of fatty liver in ultrasound scans to increase hepatology referrals and predict significant liver fibrosis.

Study results indicated that measures taken to stem the spread of COVID-19 may have also reduced rates of conjunctivitis, or pink eye.

Findings of a machine learning-based deep phenotyping approach found a myriad of factors associated with severe disease in atopic dermatitis, including age between 12 and 21 years or older than 52 years, lack of physical activity, and incidence of alopecia areata.

New research found that residual inflammation in ultrasound images was associated with patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) with low disease activity, but not in patients in remission.

Will Nutland, DrPH, is cofounder of PrEPster, an honorary assistant professor at the London School of Hygiene and Tropical Medicine, and an activist.

The Alliance of Community Health Plans (ACHP) recently released its 2021 Report on Affordability. In this episode of Managed Care Cast, we speak with the organization about the steps that its payer members are taking to lower costs through offerings such as virtual-first care, remote patient monitoring, and other new products, some of which were created because of the pandemic.