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Based on positive data from the phase 3 CANDOR study presented at the 2019 American Society of Hematology Annual Meeting, Janssen announced yesterday the submission of a supplemental biologics license application to the FDA seeking approval of daratumumab in combination with carfilzomib and dexamethasone for relapsed/refractory multiple myeloma.

While many Americans may associate firearm-related suicides with access to handguns, a report released this month documents the high prevalence of long gun (rifle and shotgun) use in youth and rural suicide rates.

Data collected between 1995 and 2014 show prevalence and incidence of diabetes are substantially higher in First Nations people in Canada compared to other people in Ontario, according to a study published in the Canadian Medical Association Journal.

The 2021 budget request from the Trump administration involves budget cuts for agencies such as HHS, CDC, and the Environmental Protection Agency; an investigational treatment for Alzheimer disease failed to slow or stop cognitive decline in patients involved in an international clinical trial; CDC confirmed a new case of coronavirus in San Diego, California.

Compared with standard care, patients with Parkinson disease and related disorders who received palliative care exhibited improved quality of life and better symptom burden at 6 months after intervention, according to study findings.

Among the general population of the United States, 14.5% of HIV-positive individuals do not know their disease status. This rate increases to 51.5% of 13- to 24-year-olds, among whom men who have sex with men account for 80% of new HIV infections.

Patients younger than 50 years who have multiple sclerosis (MS) who receive a gastrostomy tube to enable home enteral feeding live longer than those older than 50 years, according to a study published in Multiple Sclerosis Journal- Experimental, Translational, Clinical.

There are more than 36 million smokers in the United States today, and most (70%) admit they want to quit. Individuals who decide to quit see a smaller risk of heart disease within 1 to 2 years, along with reduced risks of stroke and peripheral vascular disease. However, annual deaths from smoking still exceed 480,000 in the United States, where over 16 million live with smoking-related diseases that include infertility, lung cancer, and chronic obstructive pulmonary disease.

Biomedical engineers at Duke University constructed an advanced disease model for blood vessels prompting insights into Hutchinson-Gilford progeria syndrome, according to a study published in Stem Cell Reports.

Avalere Health released an analysis outlining estimated savings that states electing to opt into the Health Adult Opportunity program need to generate in order to remain below capped funding levels mandated in the Trump administration’s new Medicaid initiative.

The reported death toll of the coronavirus in China has exceeded that of the SARS crisis from 17 years ago; the Trump administration delayed a signature healthcare initiative aiming to increase dialysis at home and transplants for US kidney patients; nearly 170 organs could not be transplanted due to transportation issues on commercial flights.

Enrollment in AIDS Drug Assistance Programs (ADAPs)–funded Qualified Health Plans (QHPs) is associated with viral suppression (VS) across states and demographic groups. People living with HIV who engage in care and have QHPs have a higher VS rate than those who received medications from direct ADAPs.

The researchers hope the findings could one day lead to cell replacement therapies for respiratory diseases, including chronic obstructive pulmonary disease.

Where do migraines begin in the brain and what has neuroimaging identified so far about how the disease alters pain processes and functioning? A recent article reviewed what is known so far.

Researchers analyzed how cognitive ability relates to ambulatory status in Parkinson.

The article identifies issues such as poor socioeconomic background and lack of family and social support as factors in poor medication adherence, which today are recognized as social determinants of health

Scientists have long known that both microglia and blood-derived macrophages play roles in how the central nervous system responds to demyelination, which occurs in multiple sclerosis. A new study explains how the two interact.

In 2017, heart failure contributed to 1 in 8 deaths. This inability of the heart to function at its optimal level led to an estimated $30.7 billion in annual healthcare costs in 2012, including healthcare services, medicines, and missed work.

New research finds salivary antioxidants and oxidative stress could be important biomarkers for plaque psoriasis.

Scientists say they know which isoform of a key protein is most likely to lead to a rare type of muscular dystrophy.

A new review article says neuroinflammation and oxidative stress appear to act together to weaken the diabetic retina and optic nerve; the authors say these insights could someday lead to better therapies to prevent diabetic retinopathy.

This week, top managed care stories included survey results on oncology practices’ willingness to take on risk; a warning of flu among children in detention centers; study findings establishing a link between circadian rhythm and type 2 diabetes.

The plan represents the latest element of the Trump administration’s comprehensive approach to renal care, which seeks to keep patients from advancing to dialysis. For those who do, the plan promotes transplants and home dialysis options.

There are shortcomings in the ways we have approached value assessment to date, writes the executive director of the Innovation and Value Initiative.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

A study shows young adults prefer short-term perks to long-term benefits; $4 million has been stolen from Mississippi's welfare fund; Los Angeles has reported 5 confirmed cases of measles.

When effectively integrated into healthcare systems, well-vetted and scientifically backed healthcare quality measures can have significant impacts on patient health, stressed Shantanu Agrawal, MD, president and CEO of the National Quality Forum, at the New Jersey Health Care Quality Institute’s Quality Breakfast on February 6.