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Splenomegaly, or enlargement of the spleen, is common in patients with Philadelphia-negative myeloproliferative neoplasms, and it is associated with symptoms like early satiety and abdominal pain. The role that splenomegaly has in terms of quality of life and prognosis in primary myelofibrosis is fairly well understood, but it has been less frequently investigated among patients with essential thrombocythemia (ET) and polycythemia vera (PV).

An executive with Jazz Pharmaceuticals said the ability to extend survival time in patients with secondary AML, and potentially offer them improved odds for transplant is an advance over traditional chemotherapy.

The results suggested that fusion events contribute to the complexity of acute myeloid leukemia and typically result from chromosomal rearrangements.

We polled our readers to find out which of 5 stories they thought was the most important healthcare story of the year. Here are the results.

Water fluoride concentrations were associated with higher odds of reports of snorting, gasping, or stopping breathing while sleeping at night.

Maximal inspiratory pressure (MIP) is associated with leg muscle strength in patients with chronic obstructive pulmonary disease (COPD), but not with walking distance or symptoms exhibited by the same patients, according to a recent study.

Patients with acute heart failure often require immediate treatment to restore optimal heart function. The 2 primary methods of revascularization are coronary artery bypass graft and percutaneous coronary intervention, but the preferred strategy for use in these patients requires clarification due to risk.

From linguistic dissonances of medical terminology to the generation of new care pathways for Medicare patients, the top 5 most-read articles of The American Journal of Accountable Care® spanned topics relevant to both patients and providers in 2019.

There are 12 clinical trials underway investigating various combination treatments for HIV and AIDS, but a cure remains elusive. Few studies have attempted to qualify and quantify the risk HIV-positive individuals claim they would take if it meant a cure could result.

A recently published review in Frontiers in Immunology highlights the efficacy of Janus kinase inhibitors as treatments for several dermatological ailments, including psoriasis. Authors described how newly researched pathologic factors have changed therapeutic practices used to treat inflammation and autoimmunity.

Just as physical therapists (PT) or occupational therapists (OT) help patients overcome barriers to increased mobility, referral challenges can be overcome with the right people, processes, and technology.

In a recently published multicenter clinimetric study, researchers determined the extent to which the American Life Balance Inventory (LBI) is successful in measuring the same factors in several European countries.

The report suggests that removing barriers to coverage, as well as reducing medication costs for people with private insurance, would help decrease cost-related nonadherence to HIV therapies.

In a narrative review published in Frontiers in Neurology, researchers compiled evidence from various studies on the relationship between caffeine and migraines. From the data collected, researchers concluded that the relationship between them remains vague.

Advances in continuous glucose monitoring, reimbursement for genetic testing, and payment models in oncology care were popular with readers of the Evidence-Based series.

A team at The University of Texas MD Anderson Cancer Center in Houston led by original pioneers in immuno-oncology have published a paper in Nature Medicine that discusses an immune-suppressing enzyme that was strongly present in glioblastoma but not in 5 other tumor types the team studied.

In 2019, the peer-reviewed research published in The American Journal of Managed Care® (AJMC®) that drew the most readers included studies on value-based arrangements, out-of-network payment policies, and more.

Thomas C. Corbridge, MD, FCCP, is a GSK medical expert and an emeritus physician and adjunct professor of medicine at Northwestern University, Feinberg School of Medicine in Chicago, Illinois. Dr. Corbridge received his medical degree from the University of Chicago Pritzker School of Medicine and has been in practice for over 30 years. Dr. Corbridge specializes in pulmonary and critical care medicine and is experienced in asthma, chronic obstructive pulmonary disease and general pulmonology.

Although there were many updates in various facets of diabetes care, one change stood out. New recommendations call for 2 drug classes to be used to treat patients with type 2 diabetes (T2D) and comorbidities: sodium glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists.

The use of antiretroviral therapy has allowed patients with HIV to have a life expectancy that approaches the lifespan of those without HIV. Despite this progress, however, HIV-associated neurocognitive disorders remain prevalent, and range from mild problems with memory, language, and reasoning to more severe HIV-associated dementia.

In 2019, The American Journal of Managed Care® team interviewed key opinion leaders nationwide. Here are the top 5 most-watched interviews from this year.

Drug maker Alnylam Pharmaceuticals has announced that the ILLUMINATE-A trial, a phase 3 study of lumasiran, an investigational RNA interference product targeting glycolate oxidase, met its primary end point in a study of patients with primary hyperoxaluria type 1 (PH1).

AJMC® presents the results of our online poll of the top healthcare stories of 2019.

In a news brief published by AHIP, initiatives employed by health insurance providers AmeriHealth Caritas, Geisinger, Horizon Blue Cross Blue Shield of New Jersey, and UPMC plan to address issues ranging from the opioid crisis to behavioral healthcare access.

On Friday, December 20, President Trump signed 2 spending packages totaling $1.4 trillion to fund the federal government for the rest of the fiscal year. The package allows federal funds to be allocated to the National Institutes of Health and CDC for the purpose of conducting research on gun violence for the first time in 2 decades.

Two new classes of drugs that offer significant clinical benefits for patients with diabetes and heart failure dominated medical conferences in 2019. Meanwhile, ovarian cancer guidelines were updated to add new therapies and the intersection of consumer health technology and cardiology also took over headlines. Read on for more.

Hospital and advocacy group opposition to state public options could foretell trouble for national single-payer efforts; electronic health records (EHRs) present new opportunities for fraud; the FDA has approved the first generic versions of apixaban (Eliquis).