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Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Reporting on their findings in the British Journal of Haematology, researchers have used immunohistochemistry (IHC) to leverage p53 expression as an identifier of mantle cell lymphoma (MCL) patients carrying mutations in tumor protein p53 (TP53), an indicator of poor prognosis in the disease.

This week in managed care, the top news includes survival improves among wait-listed heart transplant candidates, the Trump administration offers a progress report on its kidney care initiative, and panelists say choice is vital to the biosimilar savings picture.

Patients with psoriasis and psoriatic arthritis are at a greater risk for osteopenia and osteoporosis, but the associate is the result of secondary factors, such as medication.

A new phase 1 trial will test aerosolized chemotherapy in patients with cancer; Uber and NimbleRx partner to deliver prescriptions; Missouri prisons see a rise in coronavirus disease 2019 (COVID-19) cases.

For multiple sclerosis, the therapy will be sold as Kesimpta by Novartis; it is administered by patients once a month through the Sensoready autoinjector pen.

In a Complete Response Letter, FDA is requesting additional data from Gilead Sciences for its investigational treatment for moderately to severely active rheumatoid arthritis (RA).

In 2 surveys, employers identified efforts to increase availability of virtual care, support employees undertaking greater caregiving roles, and address social and health inequities as a result of the pandemic.

Reports of child abuse fell due to the coronavirus disease 2019 (COVID-19) pandemic; higher levels of the new coronavirus were found in children than in hospitalized adults; Michigan will pay $600 million to Flint residents.

Through the partnership between Innovaccer and Emtiro Health, data utilization will work to delineate and address social aspects known to affect the health of populations nationwide, said Kelly Garrison, CEO at Emtiro Health, and Paul Grundy, MD, chief transformation officer at Innovaccer.

In individuals with type 2 diabetes and comorbid obesity, the metabolic benefits of gastric bypass surgery and diet were similar and related to weight loss itself, but it had no clinically important effects independent of weight loss.

Sanofi and Johnson & Johnson are making moves to expand their autoimmune portfolios with recently announced acquisitions.

Gay, bisexual, and other men who have sex with other men (MSM) during episodes of high-risk behavior could benefit from short-term use of preexposure prophylaxis (PrEP) to lessen their chances of contracting HIV, a new study reports.

According to a review published in Eye and Brain, the use of OCT-A, a noninvasive imaging technique for analyzing the retinal and choroidal microvasculature in vivo, can play a pivotal role in the detection and monitoring of neurodegenerative diseases.

The FDA rejects Gilead’s new drug application for filgotinib; new survey results on mental health care access for LGBTQ youth; Anthony S. Fauci, MD, thinks a mandatory coronavirus disease 2019 (COVID-19) vaccination is unlikely.

German researchers find viral RNA in kidneys of patients who died from COVID-19.

Advanced age, prolonged use of non-invasive ventilation (NIV), and unsuccessful response to NIV are independent predictors for long-term mortality in chronic obstructive pulmonary disease (COPD), according to a recent report.

Ruxolitinib plus etanercept showed positive results for the treatment of steroid-refractory severe acute graft-versus-host disease.

Secukinumab 150 mg improves signs and symptoms of patients with nonradiographic axial spondyloarthritis, according to results of the PREVENT trial published in Arthritis & Rheumatology.

In individuals under the age of 50, both total body obesity and abdominal obesity were associated with greater migraine prevalence and attack frequency, according to a study published in The Journal of Headache and Pain.

The prevalence of such sleep disorders as narcolepsy and obstructive sleep apnea increased appreciably from 2013 to 2016. It is unknown whether this is due to increased awareness or increased incidence.

Although the effects of stress and anger on ischemic heart disease and arrhythmia are well known, they are less established in heart failure, particularly those with reduced ejection fraction.

New guidelines from the American College of Physicians and the American Academy of Family Physicians are cautioning providers against treating patients with acute pain from musculoskeletal injuries with opioids.

An HHS report outlines efforts to reduce kidney failure and increase options such as home-based dialysis. COVID-19 has made kidney care a higher priority.

Findings published in JAMA Network Open show ICD-10 codes perform poorly in capturing COVID-19-related symptoms, highlighting the critical need for meticulous data validation to feed multicenter registries built from electronic medical records.

The coronavirus disease 2019 (COVID-19) is now the third-leading cause of death in the United States; the FDA issued an alert for a COVID-19 test; promoting pediatric eye care as schools go virtual.

The Adjuvant Platinum and Taxane in Triple-Negative Breast Cancer trial investigated this combination adjuvant treatment vs the standard-of-care anthracycline plus docetaxel among patients with operable disease.

An investigation into the use of fingolimod as antiretroviral therapy against HIV-1 revealed 2 potential targets for the immunosuppressive drug: S1P receptors and SAMHD1, an antiviral restriction factor.