Clinical

The idea of quality care for rheumatoid arthritis (RA) often varies among the patient, clinician, and healthcare provider. However, there is a lack of representation of the patient’s perspective involved in the quality indicators that are the current standards for RA outcomes.

There’s a lot happening in clinical practice with immunotherapy treatments: expanded indications for nivolumab and ipilimumab, biomarkers to judge patient response to combinations, and developments with CAR-T.

There is an association between computed tomography (CT) detectable structural changes in the lungs of patients with chronic obstructive pulmonary disease (COPD) and changes in bacterial communities that influence alterations in the relationship between microbes and host cells, according to a new study published in PLOS One.

The approval follows a review of phase 2 results from CheckMate-142.

Enasidenib (Idhifa), developed by Celgene and Agios, has been granted FDA approval in tandem with a companion diagnostic test to detect IDH-2 mutations.

Patients often stop statin treatment following an adverse reaction; however, new research finds an association between continued statin prescriptions after an adverse reaction and a decreased incidence of death and cardiovascular events.

The FDA has expanded the indication of Bristol-Myers Squibb’s Yervoy (ipilimumab) to include the treatment of pediatric patients 12 years of age and older with unresectable or metastatic melanoma.

Recently, there have been efforts to reduce opioid use instead of increasing pain relief, and authors of a JAMA Viewpoint article argue that the movement to eliminate opioids for treating chronic pain is unnecessary.

Venetoclax (Venclexta), in combination with low dose cytarabine, has been granted a breakthrough therapy designation for use in elderly, treatment-naive patients with acute myeloid leukemia (AML) who cannot handle intensive chemotherapy.

A new study has analyzed data from randomized controlled trials in oncology that used surrogate endpoints and measured their relation with treatment effectiveness and patient survival in the real world.

Study used gene biomarker to identify which patients with colon cancer would not benefit from chemotherapy.

Patient-reported outcomes (PROs) can demonstrate the effects of a disease or treatment. By using patient questionnaires, the results can be analyzed to predict clinical outcomes in medical research for diseases, including multiple sclerosis (MS).

In recent years, biologic disease-modifying antirheumatic drugs (DMARDs) have advanced the treatment of rheumatoid arthritis (RA). However, poor adherence to treatments have increased the patient and society burden of the chronic disease.

A review of past literature on topical corticosteroid phobia in atopic dermatitis sought to better understand a phenomenon that is a major factor in treatment failure.

The age a woman experiences natural menopause is associated with her risk of developing type 2 diabetes.

In a study designed to identify the relevant cost per number needed to treat for the 2 biological disease-modifying antirheumatic drugs tocilizumab (TCZ) and abatacept, researchers determined that TCZ had a higher efficacy.

There are multiple factors that can affect how patients respond to treatment or how their health is maintained. One that is gaining more attention is how social interactions can benefit a person’s health.

Social interaction during chemotherapy treatments can positively influence a cancer patient’s health through improving patient outcomes and patient survival rates.

A poster session at the 2017 American Society of Clinical Oncology Annual Meeting presented the trial details of IRONCLAD, a randomized phase 3 study of ibrutinib versus no consolidation following autologous hematopoietic stem cell transplantation for activated-B-cell subtype relapsed diffuse large B-cell lymphoma.

In a late-breaking abstract at the 2017 American Society of Clinical Oncology Annual Meeting, researchers presented an interim analysis of a randomized phase 2 trial of second- or third-line nivolumab, with or without ipilimumab, in patients with second- or third-line malignant pleural mesothelioma.