Clinical

The FDA has approved the first chimeric antigen receptor-T (CAR-T) treatment, tisagenlecleucel (Kymriah), for the treatment of B-cell precursor acute lymphoblastic leukemia in certain pediatric and young adult patients. The therapy represents a new frontier in cancer care.

The results of the COMPASS trial testing rivaroxaban plus aspirin in patients with coronary artery disease or peripheral artery disease showed such significant benefits for reducing ischemic events that it was stopped early, explained Deepak Bhatt, MD, MPH, of Brigham and Women's Hospital and Harvard Medical School.

A study published in JCO Precision Oncology has identified an association between genetic inheritance and patients’ response to efficacy and toxicity in the phase 3 ECOG-ACRIN-5103 trial.

For each level of cardiovascular risk, lifestyle factors remain a significant contributor that can be modified to reduce risk. However, some risk will remain nonmodifiable and require therapy, according to panelists during a session on cardiovascular prevention at the European Society of Cardiology Congress 2017, held August 26-30 in Barcelona, Spain.

Trial results that will be presented at the European Society of Cardiology Congress 2017 in Barcelona, Spain, will open up a new window into treatment for patients at risk of major cardiovascular events, explained Steven E. Nissen, MD, of Cleveland Clinic, at the start of the conference.

Chimeric antigen receptor (CAR)-T cells can re-expand in a lymphoma patient months after the initial infusion and can also be active against the patient’s cancer, according to a new study.

Medicinal cannabis has become increasingly accepted in the United States and is commonly used for pain management. Despite its growing popularity as a treatment, there is little evidence available about the harms and benefits of cannabis utilization.

The brains of women are significantly more active than the brains of men, according to the largest functional brain imaging study to date conducted by Amen Clinics. This explains why there are higher rates of some conditions, such as attention-deficit/hyperactivity disorder (ADHD), in men compared with women, who have higher rates of depression.

A new study in the Journal of Clinical Oncology identifies an increased role for physicians in boosting human papillomavirus (HPV) vaccination rates among childhood cancer survivors to reduce their risk of a second cancer.

According to a new study published in Cancer, an annual screening mammogram starting at age 40 has the greatest impact on reducing mortality.

Probiotics are often believed to stimulate healthy immune function, but a new study did not find significant evidence that a supplement of lactobacillus prevents eczema, which is a common precursor to asthma.

Researchers can determine the best treatments for skin disorders, like atopic dermatitis and ringworm, by first observing how they benefit pets with the same conditions.

Study assessed the patterns of care for biologic-dosing outliers and nonoutliers in patients with rheumatoid arthritis.

A new oral dosage form of olaparib (Lynparza) has been approved as maintenance treatment in women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, who are in a complete or partial response to platinum-based chemotherapy.

Researchers from the United States, Netherlands, and Denmark have collaborated on developing a new liquid biopsy test that can detect circulating cell-free DNA in patients with early-stage cancer.

The Institute for Clinical and Economic Review (ICER) released a Final Evidence Report that found an absence of sufficient evidence to confirm the efficacy of abuse-deterrent formulations (ADFs) of opioids in decreasing the opioid abuse levels of the greater population.

A new study, published in the journal Nature, has confirmed the efficacy of a melanoma vaccine targeted against 20 predicted personal tumor neoantigens in 6 patients.

Gastroenterologists favorably view Janus kinase (JAK) inhibitors for utilization in treating inflammatory bowel disease (IBD), according to a recent survey conducted by Decision Resources Group.

A retrospective study in patients with newly diagnosed cancer has identified an increased risk of cardiovascular (CV) abnormalities that are aggravated by cancer stage.

Chronic obstructive pulmonary disease (COPD) is typically diagnosed through a patient history exam and a physical exam; however, because symptoms of COPD-dyspnea, cough, and wheeze-are common symptoms for many other diseases, many patients are misdiagnosed due to the lack of necessary testing performed to confirm the presence of the disease.

Atopic dermatitis (AD) presents a significant humanistic burden on the quality of life among adult patients. Due to its public health impact and negative symptoms, the development for new and more effective treatments are necessary.

The Institute for Clinical and Economic Review (ICER) has released a draft version of their scoping document that will compare the clinical effectiveness and value of 2 chimeric antigen receptor (CAR)-T cell treatments being reviewed by the FDA.