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Opinion|Videos|July 23, 2026 (Updated: July 16, 2026)

Defining Alzheimer's Disease Agitation: Diagnostic Criteria, Symptoms, and Disease Course

Kavita Nair leads the discussion on defining Alzheimer's disease agitation.

Kavita Nair leads the discussion on defining Alzheimer's disease agitation. Anton Porsteinsson outlines IPA provisional diagnostic criteria (2015, made permanent 2023): agitation must occur in context of cognitive impairment, include ≥1 of 3 behavioral manifestations (excessive motor activity, verbal aggression, physical aggression), persist ≥2 weeks, cause distress and disability, and not be attributable to another condition. Agitation can present as early as pre-dementia stages (MCI) and typically peaks during moderate to early severe stages.


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