Clinical

The AJMC® clinical page includes all the published content across AJMC.com, The American Journal of Managed Care® and Evidence-Based Oncology™ on a variety of specialties, including dermatology, cardiology, oncology, and rheumatology.

Posters Show Success of RBX2660 in Reducing C difficile Recurrence, Reviving Microbiome

May 22nd 2022, 8:15pm

Article

A pair of posters presented at Digestive Disease Week 2022 showed the efficacy of an investigational biotherapeutic in preventing Clostridioides difficile infection recurrence and restoring the microbiome.

TIGIT May Hold Potential as a Marker of CAR T-Cell Exhaustion and Therapeutic Target in Non-Hodgkin Lymphoma

May 22nd 2022, 7:05pm

Article

A recent study identified TIGIT as a marker of chimeric antigen receptor (CAR) T-cell exhaustion and found it to improve CAR T-cell therapy efficacy in preclinical models.

Radiomics-Based Models Can Accurately Diagnose MM and Bone Metastases, Study Finds

May 21st 2022, 7:43pm

Article

Differentiation between multiple myeloma (MM) and bone metastases from other cancers can be difficult, but radiomics-based models have potential to improve diagnostic accuracy.

Biliary Tract Cancer Rates Vary by Country; Prevention Efforts Needed

May 21st 2022, 12:56am

Article

Authors wrote that their analysis was the first to combine incidence and mortality of overall BTC, and its anatomic subtypes, into a single study

Study: Sacubitril/Valsartan Led to Fibrosis Improvements in HFrEF

May 20th 2022, 10:02pm

Article

This study evaluated levels of 4 biomarkers associated with heart failure with reduced ejection fraction (HFrEF) before and after treatment with the angiotensin receptor neprilysin inhibitor sacubitril/valsartan.

FDA Approves Dupilumab as First Therapy for Eosinophilic Esophagitis

May 20th 2022, 7:56pm

Article

Eosinophilic esophagitis is a chronic inflammatory disorder in which eosinophils, a type of white blood cell, proliferate in the esophagus, causing difficulties with eating and swallowing.

Secukinumab Improved HRQOL, Symptoms in Pediatric Generalized Pustular Psoriasis

May 20th 2022, 5:30pm

Article

Over 48 weeks, secukinumab was shown to be effective and safe in a small study of 18 children with generalized pustular psoriasis in China.

Case Study: Caplacizumab May Salvage Refractory Immune TTP Following COVID-19 Vaccine

May 20th 2022, 4:08pm

Article

While suggesting that the disorder be included in the differential diagnosis of thrombocytopenia following vaccination, the group emphasized that the benefits of global vaccination against the virus outweigh the risk of this rare complication.

Defining Value Among Treatment Options

May 20th 2022, 2:51pm

Video

Payer decision-makers discuss defining value among agents for unintended pregnancy, uterine fibroids, and endometriosis.

Evolving Treatment Strategies for UF and Endometriosis

May 20th 2022, 2:29pm

Video

A panel of experts discuss treatment selection among contraceptive agents and evolving treatment strategies for uterine fibroids and endometriosis.