Enhancing Chronic Kidney Disease Treatment With Guideline-Directed Medical Therapies Through Electronic Alert Systems and Integrated Care Management Initiatives

Key Takeaways

• Electronic alerts can operationalize CKD identification by surfacing eGFR and albuminuria criteria, stratifying risk, and triggering standardized pathways for GDMT initiation and follow-up.
• Integrated care management models align primary care, nephrology, pharmacists, and nursing to support titration, lab surveillance, adherence, and patient education around kidney- and cardio-protective therapies.
• Clinical decision support at Yale New Haven Health is being assessed for real-world impact on SGLT2 inhibitor/RAASi prescribing, monitoring safety signals, and reducing clinical inertia.
• Evaluation frameworks emphasize equitable deployment, minimizing alert fatigue, and measuring downstream endpoints such as CKD progression, cardiovascular events, hospitalizations, and referral appropriateness.