Opinion|Videos|November 12, 2024

Fezolinetant in Focus: Key Findings From the SKYLIGHT Trials

Name: Fezolinetant in Focus: Key Findings From the SKYLIGHT Trials
Uploaded: 2024-11-12T13:05:00.000Z
Duration: pt3m57s
Description: Fezolinetant in Focus: Key Findings From the SKYLIGHT Trials

Author(s)Ryan Haumschild, PharmD, MS, MBA, CPEL, JoAnn V. Pinkerton, MD, FACOG, MSCP , Alexa N. Fiffick, DO, MBS, MSCP

Key Takeaways

Fezolinetant's approval was based on SKYLIGHT 1, 2, and 4 trials, which were randomized, double-blind, and placebo-controlled.
The trials focused on women with moderate to severe vasomotor symptoms, evaluating fezolinetant's safety and efficacy.
Significant reductions in VMS frequency and severity were observed with fezolinetant compared to placebo.
Safety profiles were favorable, with adverse events similar to placebo, highlighting fezolinetant's potential as a non-hormonal treatment option.

Panelists discuss the methodologies of the SKYLIGHT 1, SKYLIGHT 2, and SKYLIGHT 4 trials that supported the approval of fezolinetant for moderate to severe vasomotor symptoms (VMS) and examine the key safety and efficacy results derived from these studies.

Video content above is prompted by the following:

(SMITH) The approval of fezolinetant for moderate to severe VMS was based on the SKYLIGHT 1, SKYLIGHT 2, and SKYLIGHT 4 trials. Briefly describe the methodology of these studies.
(FIFFICK) What were the key safety and efficacy results from the SKYLIGHT studies?

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Fezolinetant in Focus: Key Findings From the SKYLIGHT Trials

Key Takeaways

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