Important Updates in the Management of Uncomplicated UTIs

Panelists discuss how American Urological Association (AUA) guidelines for recurrent uncomplicated urinary tract infections (UTIs) in women recommend culture-confirmed diagnosis, prophylactic antibiotics, nonantibiotic prevention, self-initiated treatment, and behavioral modifications while noting pivmecillinam’s recent FDA approval. Pivmecillinam features a penicillin-binding protein 2 inhibition mechanism with 85% to 95% efficacy against gram-negative uropathogens, including extended-spectrum β-lactamase producers; minimal intestinal flora disruption; low resistance rates; and primarily mild gastrointestinal adverse effects.

EP: 1.Differentiating Uncomplicated and Complicated Urinary Tract Infections (UTIs)

EP: 2.Trends in Uncomplicated UTIs

EP: 3.Exploring Social Determinants of Health in Uncomplicated UTIs

EP: 4.Examining Uncomplicated UTI Recurrence

EP: 5.Role of Patients’ Education in Uncomplicated UTIs

EP: 6.Patient Burden Associated With Uncomplicated UTIs

EP: 7.Minimizing Antibiotic Resistance Development in Uncomplicated UTIs

EP: 8.Examining the Need for Updated Guidelines for Uncomplicated UTIs

EP: 9.Comparing Standard-of-Care Antibiotics for Uncomplicated UTIs

EP: 10.Patient Factors Influencing Antibiotic Selection in Uncomplicated UTIs

EP: 11.Recurrence Rates in Uncomplicated UTIs

EP: 12.Economic Burden Associated With Uncomplicated UTIs

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EP: 13.Important Updates in the Management of Uncomplicated UTIs

EP: 14.Exploring Novel Options for the Management of Uncomplicated UTIs

EP: 15.Comparing Newer With Traditional Agents in Uncomplicated UTIs

EP: 16.Payer-Related Barriers With Therapies Used for Uncomplicated UTIs

EP: 17.Final Panel Thoughts on Uncomplicated UTI Management

Video content above is prompted by the following:

• Summarize the current AUA guideline recommendations in managing recurrent uncomplicated UTIs in women.
• Pivmecillinam was recently FDA approved in April 2024. Briefly describe the mechanism of action of pivmecillinam and its clinical efficacy and safety profile.

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