Reversing Rising CRC Deaths Through Early Detection, Patient Navigation, and Policy Changes: Jordan Karlitz, MD

In the final part of his interview with The American Journal of Managed Care^®, Jordan Karlitz, MD, of Exact Sciences, discussed clinical-, behavioral-, and policy-based interventions he believes could most effectively reverse the rising trend in colorectal cancer (CRC) mortality among adults aged younger than 50.

Regarding clinical interventions, he emphasized the 3 pillars of early CRC detection: acting promptly on concerning symptoms, knowing one’s family cancer history, and getting screened on time. As Karlitz noted, individuals at average risk should begin CRC screening at age 45, while those with a family history of cancer may need to start earlier.

He also highlighted that many behavioral risk factors, such as having a sedentary lifestyle and/or certain dietary patterns, are modifiable and can be addressed to minimize CRC risk. From a policy perspective, Karlitz underscored the importance of minimizing or eliminating out-of-pocket costs for screening, noting that significant progress has already been made in this area.

He concluded by stressing the crucial role of patient navigation, particularly in guiding individuals through CRC screening. For noninvasive tests like Cologuard, navigation includes ensuring patients understand what a positive result means and the need for a timely follow-up colonoscopy.

Karlitz drew on experience from both his current role as senior medical officer of screening at Exact Sciences and his previous position as chief of the gastroenterology and hepatology division at Denver Health Medical Center. At Exact Sciences, he explained that robust patient navigation contributes to the high adherence seen with Cologuard testing. Meanwhile, at Denver Health Medical Center, navigation helped move necessary patients from primary care into the endoscopy unit.

Watch parts 1 and 2 to learn more about the factors driving rising CRC-related deaths in younger adults and the 3 pillars of prevention and early detection.

Reference

McCormick B. CRC becomes leading cause of cancer-related death in younger adults, highlighting prevention gaps. AJMC^®. January 26, 2026. Accessed February 12, 2026. https://www.ajmc.com/view/crc-becomes-leading-cause-of-cancer-related-death-in-younger-adults-highlighting-prevention-gaps