Commentary|Podcasts|February 26, 2026

Scalable Strategies Boost Heart Failure Prescription Fills: Weston Blakeslee, PhD

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Low-cost, scalable interventions can improve first-fill adherence, reduce avoidable hospitalizations, and support patient-centered strategies.

Medication adherence remains one of the most persistent and costly challenges in chronic disease management, particularly for patients with heart failure, where missed or delayed therapy can accelerate disease progression and increase the risk of hospitalization. For managed care organizations and health systems operating under value-based care models, improving adherence is both a clinical priority and a financial imperative. Yet many traditional adherence interventions—such as intensive case management, in-person counseling, or complex outreach programs—can be resource-intensive and difficult to scale.

Emerging evidence suggests that simpler, digitally enabled interventions may offer meaningful improvements with far less operational burden. On this episode of Managed Care Cast®, Weston Blakeslee, PhD, vice president of clinical intelligence at DrFirst, discusses findings from a recent study examining the impact of text message nudges on prescription fill rates among patients with heart failure. The research found that patients who received timely text reminders were significantly more likely to fill their prescriptions, improving the odds of medication initiation by approximately 19%.

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