Rose is a freelance writer for The American Journal of Managed Care® (AJMC®), where she previously worked as an editor.
She has a BA in journalism & media studies and Spanish from Rutgers University. You can connect with Rose on LinkedIn.
Study Identifies Lenalidomide-Carfilzomib as Best Maintenance Treatment Option in MM
Within a selection of therapies showing efficacy over a placebo, lenalidomide-carfilzomib was a standout against the rest of the group.
Patients With Lower-Risk MF, Low- or High-Risk ET Report Significant QOL Impacts
Despite the use of therapies to address the clinical manifestations of myelofibrosis (MF) and essential thrombocythemia (ET), the symptom burdens of these conditions continue to negatively affect patient quality of life (QOL).
Sickle Cell Disease Management May Overlook Impactful Complications, Study Finds
Findings of a recent study suggest that complications of sickle cell disease (SCD) significantly contribute to morbidity and are more prevalent among older patients.
Study Highlights Sex Differences in Lymphoma Incidence and Mortality
A Swedish population-based study adds to data suggesting men have a higher risk of lymphoma and likely higher mortality.
Diagnostic and Treatment Considerations for Splanchnic Vein Thrombosis in MPN
The review highlighted key diagnostic and treatment considerations for patients with splanchnic vein thrombosis and myeloproliferative neoplasms.
Sutimlimab Improves Patient-Reported QOL in Cold Agglutinin Disease
An analysis of patient-reported outcomes from the pivotal CARDINAL trial of sutimlimab in cold agglutinin disease found that quality of life (QOL) improved and persisted throughout treatment.
Review: More Research on Treatment for Extramedullary Hematopoiesis in Transfusion-Dependent Beta Thalassemia Is Needed
Currently, there are no clear guidelines for managing extramedullary hematopoiesis in transfusion-dependent beta thalassemia.
Adding Pharmacists to Core Hemophilia Care Teams Improves Outcomes, Patient Costs
A recent study suggests that including a pharmacist in the hemophilia comprehensive care model may improve bleeding outcomes and medication access and adherence, and lead to cost savings.
CAR T-Cell Therapy Outcomes Are Not Impacted by Baseline Renal Function, Study Finds
Renal outcomes and chimeric antigen receptor (CAR) T-cell therapy efficacy were unaffected by baseline renal status in a cohort of patients with diffuse large B cell lymphoma, but acute kidney injury during treatment was associated with worse clinical outcomes.
Managing Bleeding Disorders in Pregnancy Requires Early Diagnosis, Multidisciplinary Care
A recent review details strategies for mitigating the risks faced by pregnant patients with hemophilia or von Willebrand disease and their children.
Guidance for Evaluating for Bleeding Disorders in Suspected Child Abuse
The recommendations aim to make this type of evaluation more consistent in cases when children have suspicious bruising or bleeding patterns.
Study Supports Comprehensive Genomic Profiling for Patients With Biliary Tract Cancer
A small study suggests that comprehensive genomic profiling can help with clinical decision-making and predicting clinical outcomes in advanced biliary tract cancer, but further research is needed.
Case Report Describes Youngest Recorded Patient With Intrahepatic Sarcomatoid Cholangiocarcinoma
The rare condition can easily be confused with hepatocellular carcinoma, but immunohistochemical studies can help accurately diagnose intrahepatic sarcomatoid cholangiocarcinoma.
Review Highlights Potential of Emicizumab Prophylaxis in Acquired Hemophilia A
Morbidity and mortality remain high for patients with acquired hemophilia A, and advances in immunotherapy and hemostatic therapy are needed to improve outcomes.
Review Highlights Advances in SCD Treatment, Potential Targets for Novel Agents
The review discusses hydroxyurea and 3 additional drugs approved by the FDA—L-glutamine, crizanlizumab, and voxelotor—as well as agents currently being investigated to treat sickle cell disease (SCD).
Surgeries Can Be Safe, Effective in Patients With Hemophilia A on Emicizumab Prophylaxis
The study pooled data from 4 clinical trials to gain insight into surgical outcomes in this complex population.
ICER Releases Draft Evidence Report on Gene Therapies for Hemophilia A and B
Despite $2.5 million placeholder price tags, the Institute for Clinical and Economic Review draft evidence report considers gene therapy cost-effective versus comparators in both hemophilia A and B.
Sutimlimab Is Effective, Well Tolerated in Refractory Chronic Immune Thrombocytopenia
Sutimlimab demonstrated rapid efficacy in the study cohort, and platelet level improvements were sustained for the duration of treatment in nearly half of the participants.
Myeloid Cells Hold Promise as Cancer Immunotherapy Targets, Review Says
The review highlights current strategies for myeloid cell targeting and novel agents targeting myeloid cells for cancer treatment.
Bendamustine/Rituximab vs Sutimlimab Monotherapy for CAD Explored in New Review
A review published in Transfusion Medicine Reviews discussed the 2 therapeutic approaches and their pros and cons for treating cold agglutinin disease (CAD).
Early Timing, Optimal Conditioning Maximize Outcomes of Allo-SCT in MDSs and MPNs
A review published in Frontiers in Oncology explored the application of allo-SCT for myelodysplastic syndromes and myeloproliferative neoplasms.
The Impact of Orphan Drug Legislation on the Beta Thalassemia Treatment Landscape
Orphan drug designation incentives have helped boost enthusiasm for researching and developing drugs for beta thalassemia, a new review concludes.
US Cutaneous T-Cell Lymphoma Incidence Increased From 2000 to 2018
The findings, which contradict prior North American studies, suggest that the incidence rate of the rare cancer continues to increase in the United States.
Neurofilament Light Chain Levels May Indicate Risk of CAR T–Related Neurotoxicity
A significant portion of patients who receive chimeric antigen receptor (CAR) T-cell therapy experience immune effector cell–associated neurotoxicity syndrome, and this recent study suggests neurofilament light chain protein levels may hold promise as a biomarker to identify at-risk patients.
Case Study Chronicles Onset and Treatment of Acquired Hemophilia A Following HSCT for ALL
The case emphasizes the importance for clinician awareness of the potential for rare immune-mediated disorders, including acquired hemophilia A (AHA), following allogeneic hematopoietic stem cell transplantation (HSCT).
Guidelines Needed for Managing MPNs in AYA Patients, Review Says
The management of myeloproliferative neoplasms (MPNs) in adolescent and young adult (AYA) patients is currently similar to that of older patients. However, comprehensive research is needed to form guidelines for this younger population.
How Point‐of‐Care Ultrasound May Improve At-Home Hospital Care
A recent review suggests point-of-care ultrasound can help home hospital care providers assess, diagnose, and monitor a range of conditions with relatively little additional training.
Patients and Parents Impacted by SMA May Be Optimistic About Prenatal Testing, Therapies
As the feasibility of phase 1 clinical trials for prenatal spinal muscular atrophy (SMA) therapies is explored, patient and parent input on prenatal testing and possibly treatment is a valuable tool for guiding research discussions.
Systematic Approaches to Patient Educational Needs May Benefit Those With Bleeding Disorders
Nurse-led education is an essential aspect of care for patients with bleeding disorders, but there is currently a lack of research on specific strategies to improve patient self-management through education.
Hemoglobin Improvement Correlates With Better HRQOL in Paroxysmal Nocturnal Hemoglobinuria
Post hoc analyses of the phase 3 PEGASUS trial found that clinical and hematological improvements were associated with better patient-reported fatigue and physical function outcomes in paroxysmal nocturnal hemoglobinuria, for an overall bettering of health-related quality of life (HRQOL).
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