Rose is a managing editor at The American Journal of Managed Care® (AJMC®).
She has a BA in journalism & media studies and Spanish from Rutgers University. You can connect with Rose on LinkedIn.
"Persistent" Subset of Tumor Mutations May Predict Immunotherapy Response
A study published in Nature Medicine found that certain tumor mutations are more persistent and may predict immunotherapy responses more reliably than overall tumor mutational burden.
Study Highlights Racial, Geographic Disparities in Timely Breast Cancer Care
The findings suggest that both high-risk patients and high-risk regions should be considered in clinical and policy strategies to facilitate timely breast cancer care.
Study Finds Ixazomib Beneficial in MM Patients With High-Risk Cytogenic Traits
A recent study found that ixazomib was associated with better progression-free survival versus a placebo in multiple myeloma regardless of cytogenetic risk status.
Researchers Form Novel Database of Leukemia Transcriptome Profiles
A recent study aggregated RNA sequencing data from more than 3000 samples to create a user-friendly database of transcription profiles in leukemia and related cell lines.
Axi-cel Shows Improved Quality-Adjusted Survival Versus Standard of Care in LBCL
A Q-TWiST analysis of ZUMA-7 trial data suggests that axicabtagene ciloleucel (axi-cel) in the second line is beneficial to quality-adjusted survival and is a viable option for patients with relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy.
Interstitial Lung Abnormalities Impact OS in NSCLC Patients Receiving CRT, Adjuvant Durvalumab
Pretreatment interstitial lung abnormalities were associated with worse overall and cause-specific survival in Japanese patients receiving chemoradiotherapy followed by adjuvant durvalumab for locally advanced non–small-cell lung cancer.
Real-World Data Confirm Safety, Efficacy of Durvalumab After CRT in NSCLC
A preplanned analysis of the PACIFIC-R confirms findings from the pivotal PACIFIC trial of durvalumab as consolidation therapy in unresectable NSCLC after chemoradiotherapy.
PD-L1 Warrants Further Research as Biomarker for Endometrial Cancer Therapy Response
A recent study found potential significance in PD-L1 analysis results for predicting immune treatment response in patients with advanced endometrial carcinoma.
Latest ACS Cancer Statistics Report Highlights Alarming Trends, Disparities in Prostate Cancer
Following the release of its 2023 report on cancer statistics, the American Cancer Society announced a new initiative to improve prostate cancer outcomes and reduce disparities.
Adding Social Factors to Risk Adjustment Not Enough to Reach Health Equity, Paper Says
To best improve health equity, population-based payment models should both incorporate social goals and increase payment for historically marginalized communities, a recent study has found.
Distinct Molecular Profiles in Younger vs Older Patients With MDS Identified in New Study
The relationship between aging and molecular profiles in myelodysplastic syndromes (MDS) is not well understood, but the findings suggest that different genetic alterations have distinct prognostic implications in different age groups.
Stiff Person Syndrome Spectrum Disorders: Knowledge Gaps and Future Research Considerations
Although rare, stiff person syndrome spectrum disorders can significantly affect patient quality of life, and current knowledge gaps warrant further research.
ASXL1 Mutations Associated With Worse Prognosis in MDS and AML
A recent meta-analysis found ASXL1 mutations to be independent risk factors for worse overall survival and transformation to acute myeloid leukemia in patients with myelodysplastic syndromes (MDS), as well as worse overall survival in acute myeloid leukemia (AML).
Real-world Study Confirms Clinical Benefit of Ruxolitinib in Heavily Pretreated cGVHD
A multicenter study supports the use of ruxolitinib in steroid-refractory and steroid-dependent chronic graft-versus-host disease, adding to promising clinical trial findings.
Study Identifies Sex-Related Differences in MDS Phenotypes, Genotypes, and Outcomes
Authors of the observational cohort study developed and validated novel sex-informed prognostic and genomic scoring systems for patients with myelodysplastic syndrome (MDS).
Report Details Severe Case of ARDS Following Ruxolitinib Discontinuation
The report is the first recorded case of acute respiratory distress syndrome (ARDS) that required venovenous extracorporeal membrane oxygenation and was complicated by spontaneous spleen rupture.
Phase 3 Trials in High-Risk MDS Highlight Future Directions
A recent review emphasizes a need for novel therapies, summarizes current phase 3 clinical trials, and suggests several considerations for future trials in high-risk myelodysplastic syndromes (MDS).
Review of BTK Inhibitors for Waldenström Macroglobulinemia Highlights Pros, Cons, and Future Directions
Bruton tyrosine kinase (BTK) inhibitors are currently the only FDA-approved agents indicated specifically for patients with Waldenström macroglobulinemia.
Post Hoc Analysis of IMPACT Trial Finds Triplet Regimen Effective in COPD
The findings suggest that treatment with fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) led to improvements and had a similar safety profile to both FF/VI and UMEC/VI regardless of patient chronic mucus hypersecretion status at baseline.
Genealogical Study of Primary Ovarian Insufficiency Suggests Strong Genetic Component
The population-level, mutigenerational study found that both near and distant relatives of women with primary ovarian insufficiency were at a higher risk of the condition compared with matched controls.
End-of-Life Care in Multiple Myeloma Still Requires Fine-tuning, Despite Improvements
Thirteen years of population-based data highlight substantial rates of aggressive end-of-life care and disparities in care within a publicly funded health care system in Ontario, Canada.
CBD May Improve Neurologic, Cognitive, QOL Outcomes in Sturge-Weber Syndrome
A small, prospective, open-label trial found evidence of improved quality of life (QOL) and clinical outcomes among patients with treatment-resistant Sturge-Weber syndrome when they were treated with CBD.
Unintended Pregnancy May Increase Risk of Postpartum Depression, Study Finds
The risk of experiencing symptoms of postpartum depression may be higher in women who give birth after unintended pregnancies vs those who get pregnant intentionally, according to a recent study.
Current Research and Logistical Considerations for Gene Therapy in Hemophilia
A recent review poses gene therapy as a novel treatment option with potential to reduce health care disparities globally.
Nirmatrelvir-Ritonavir Shows Safety, Efficacy in Real-world Study of High-risk COVID-19 Patients
The retrospective study evaluated outcomes in patients prescribed nirmatrelvir-ritonavir, as well as the management of drug interactions by clinical pharmacists prescribing the regimen.
Study Supports Funding for CGM to Improve Pediatric T1D Outcomes in New Zealand
Continuous glucose monitoring (CGM) systems have been shown to improve glycemia for individuals with type 1 diabetes (T1D), but they are not nationally funded in New Zealand.
Exploring Current Eosinophilic Gastrointestinal Disease Nomenclature and Management
An article published in the journal Gastroenterology & Hepatology highlights recent updates to eosinophilic gastrointestinal disease nomenclature, as well as updates related to diagnosis, pathogenesis, and treatment standards.
Review Highlights Need for Further Research, Individualized Treatments for Endometriosis-Associated Infertility
Although there is a clinically recognized association between endometriosis and infertility, the mechanisms behind the association are not fully understood.
New Clinical Guidelines Recommend Finerenone for CKD Associated With T2D
Updated Kidney Disease: Improving Global Outcomes guidelines and a consensus report with the American Diabetes Association support the use of finerenone in certain patients who have chronic kidney disease (CKD) that may be linked to type 2 diabetes (T2D).
Virtual Assistants in Teledermatology May Improve Quality of Life for Patients With Psoriasis
A prospective study found that patients and providers saw benefits while using a virtual assistant integrated into a teledermatology program.
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