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Regeneron and Sanofi vowed to appeal the ruling; analysts said that process could take at least a year. While Amgen has asked for a permanent injunction, some see payment of royalties to Amgen as a more likely outcome if Regeneron is ultimately not successful.

The top stories in managed care this week included a proposed new payment model for Medicare Part B and the swift criticism that followed the announcement, findings on variation in cost based on site of care, and cardiovascular results for Victoza.

It's no surprise that researchers were unable to come to firm conclusions about the cardiovascular safety of Contrave based on partial results. An accompanying editorial in JAMA finds that a repeat of the LIGHT saga could force FDA to demand full safety data before approval.