Multiple Myeloma

The AJMC® Multiple Myeloma compendium is a comprehensive resource for clinical news and expert insights for this cancer.

Latest News

CAR T in MM | Image Credit: LASZLO-stock.adobe.com
Dual-Target CAR T Cells Achieve 100% Response Rate in MM

July 25th 2024

This new analysis examined the investigational chimeric antigen receptor (CAR) T-cell therapy GC012F among patients with newly diagnosed and high-risk multiple myeloma (MM).

Support group image | Image Credit: Tom Merton/KOTO-stock.adobe.com
Myeloma Survivorship Program: Findings and Future Steps

July 17th 2024

Multiple myeloma | Image Credit: Felipe Caparrós-stock.adobe.com
Final GRIFFIN Trial Data Confirm Daratumumab Benefit Against MM

July 10th 2024

AJMC with Dr Suzane Lentzsch | Background image credit: ipopba - stock.adobe.com
Advancements and Challenges in Treating Relapsed/Refractory Multiple Myeloma

July 2nd 2024

multiple myeloma | Image Credit: ibreakstock-stock.adobe.com
Ide-Cel Generates Durable Responses in Functionally High-Risk Myeloma

June 28th 2024

EHA 2024: Highlights in Multiple Myeloma

Joseph Mikhael, MD, shares insights surrounding key updates in multiple myeloma management as presented at EHA 2024.

Joseph Mikhael, MD, shares insights surrounding key updates in multiple myeloma management as presented at EHA 2024.
Continuing Medical Education
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July 27th 2024

Recent Advances in BCMA-Directed Treatment in Multiple Myeloma: Insights and Application for Managed Care

1.0 Credits / Hematologic Cancer, Oncology
July 27th 2024

Keeping Pace With New Developments in Multiple Myeloma: Updates and Strategies to Optimize Bispecific Antibodies and CAR T-Cell Therapy

1.5 Credits / Oncology, Hematology, Hematologic Cancer
July 27th 2024

Addressing the Gaps and Clinical Challenges in Chronic Lymphocytic Leukemia: Updates and Strategies for Managed Care

1.5 Credits / Hematology, Hematologic Cancer, Oncology

More News

Top 5 Multiple Myeloma Articles of 2023
December 19th 2023

Top 5 Most-Read Multiple Myeloma Articles of 2023

Rose McNulty
Our top multiple myeloma (MM) content this year included research suggesting many patients still face poor prognoses despite advances, a case study of unique MM presentation, and research presented at the 2022 American Society of Hematology Annual Meeting.
Blood cells flowing | Image credit: Катерина Євтехова - stock.adobe.com
December 16th 2023

Talquetamab Dose Modifications May Lower AEs While Maintaining Efficacy in R/R Multiple Myeloma

Silas Inman
Dose modifications of talquetamab improved on-target adverse effects while maintaining responses for patients with relapsed/refractory multiple myeloma.
Illustration of T cells - Sebastian - stock.adobe.com
December 15th 2023

Patients With Multiple Myeloma Lack Awareness of CAR T-Cell Therapy, Research Says

Giuliana Grossi
The results indicated that a substantial proportion of patients, particularly in rural, less educated, and elderly demographics, are insufficiently informed about novel MM treatments, including chimeric antigen receptor (CAR) T-cell therapies and bispecific antibody alternatives.
Cardiovascular system | Image credit: appledesign - stock.adobe.com
December 8th 2023

Real-World Data Show Poor Outcomes Among Patients With ACS and Blood Cancers

Sabrina Serani
A real-world analysis found that patients with acute coronary syndrome who were also diagnosed with a hematologic malignancy had worse survival outcomes, and patients with multiple myeloma were overrepresented in the population.
Blood Cells | Image credit: Катерина Євтехова - stock.adobe.com
November 30th 2023

Study Finds ASCT Similarly Safe, Effective in Older and Younger Patients With Multiple Myeloma

Rose McNulty
A real-world study suggests high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is feasible for appropriately selected elderly patients, with similar results seen in older and younger patients.
Multiple myeloma blood testing | Image credit: luchschenF - stock.adobe.com
November 29th 2023

Belantamab Mafodotin Improves PFS in Relapsed/Refractory Multiple Myeloma

Hayley Virgil
Second-line treatment with belantamab mafodotin plus bortezomib/dexamethasone in patients with relapsed/refractory multiple myeloma is supported by findings from the phase 3 DREAMM-7 study.
Patient in the hospital | Image credit: Tyler Olson - stock.adobe.com
November 22nd 2023

Minimizing Terms for Toxicity Often Used in Multiple Myeloma Trials, Study Says

Rose McNulty
A cohort study of 65 clinical trials in multiple myeloma found that toxic effects are often described with subjective terminology that may not reflect adverse event rates reported in the studies.
Multiple myeloma blood testing | Image credit: luchschenF - stock.adobe.com
November 17th 2023

Interactions Between Tumor Genes, Microenvironment Impact Treatment Response in Multiple Myeloma

Gillian McGovern
The study findings provide the first in-depth look at the relationship between chromosomal changes in tumor cells and immune components of the tumor microenvironment.
Cardiovascular system | Image credit: appledesign - stock.adobe.com
November 10th 2023

CHIP Present Before HCT Linked With Later CVD Risk in Multiple Myeloma

Rose McNulty
The findings suggest the presence of CHIP before HCT may have potential to serve as a biomarker for CVD risk after HCT in patients with multiple myeloma.
Multiple myeloma | Image credit: David Litman - stock.adobe.com
November 2nd 2023

CAR T-Cell Therapy Responses Differ by Race and Ethnicity, Study Finds

Sabrina Serani
While response and safety may vary across racial and ethnic subgroups, progression-free survival and overall survival does not appear to differ when chimeric antigen receptor T-cell therapy is used in the treatment of patients with multiple myeloma.
Illustration of T cells | Image credit: Sebastian - stock.adobe.com
October 30th 2023

Study Identifies Mechanisms of Resistance to Immunotherapy for Multiple Myeloma

Rose McNulty
Investigators found that myeloma cells may lose or change targets and subsequently go undetected by these therapies, suggesting that screening for such changes regularly could help guide treatment.
Ixazomib molecule | Image credit: molekuul.be - stock.adobe.com
October 28th 2023

Ixazomib Shows Efficacy, Tolerability in Real-World R/R Multiple Myeloma Treatment

Rose McNulty
A study of patients with relapsed or refractory (R/R) multiple myeloma who received ixazomib-based therapy in real-world settings found the treatment effective and tolerable in clinical practice.
CAR T cell | Image credit: Alpha Tauri 3D - stock.adobe.com
October 27th 2023

Cilta-Cel Leads to High PFS Rates in Patients With Multiple Myeloma and Poor Prognostic Features

Courtney Flaherty
Patients with multiple myeloma exhibiting poor prognostic features, such as high-risk cytogenetics, soft-tissue plasmacytoma, ISS stage III disease, and triple-class exposure, experienced significant progression-free survival benefit with ciltacabtagene autoleucel.
Multiple myeloma cells | Image credit: David A Litman - stock.adobe.com
October 26th 2023

Early Relapse Shows Powerful Prognostic Value in Multiple Myeloma

Rose McNulty
Researchers identified an optimal early relapse time point to incorporate into traditional risk features and formed a novel prognostic classification utilizing both static and dynamic risk.
Multiple myeloma | Image credit: ibreakstock - stock.adobe.com
October 20th 2023

Intensive Therapy More Effective vs Less Intense Therapy in Frail Patients With MM

Rose McNulty
A recent study suggests that more intensive triplet therapy is more effective than less intensive doublet therapy in frail patients with newly diagnosed multiple myeloma (MM), and that more intensive treatment may even improve frailty itself.
Blood Cells | Image credit: Катерина Євтехова - stock.adobe.com.jpg
October 13th 2023

Immunotherapy Sequences May Lead to Disease Resistance/Relapse in Myeloma

Conor Killmurray
BCMA and GPRC5D loss in patients with multiple myeloma may lead to resistance to continuous treatment with anti–BCMA and anti–GPRC5D agents.
Immune cells attacking cancer | Image credit: Spectral-Design - stock.adobe.com
October 6th 2023

Immune System Traits Linked With Remission in Multiple Myeloma

Rose McNulty
A recent study suggests that a patient’s immune microenvironment plays a key role in the depth and duration of response to multiple myeloma treatment.
Nurse helping man exercise | Image credit: Studio Romantic - stock.adobe.com
September 28th 2023

Physical Activity Improves Performance, Frailty Scores, PROs in Multiple Myeloma

Morgan Bayer
Exercises such as resistance training and walking were safe and effective interventions that were associated with improved frailty scores and patient-reported outcomes (PROs) in patients with multiple myeloma receiving systemic treatment.
Blood cells flowing | Image credit: Катерина Євтехова - stock.adobe.com
September 22nd 2023

Many Factors Influence Selection of CAR T Therapy, Bispecifics in Myeloma

Kyle Doherty
Bispecific antibodies may be more broadly applicable as treatment for patients with multiple myeloma in the short-term, according to Ajai Chari, MD.
Blood cells | Image credit: flashmovie - stock.adobe.com
September 20th 2023

Despite Treatment Improvements, Second Primary Malignancies Adversely Affect MM Prognosis

Rose McNulty
In a real-world study using data from patients diagnosed with multiple myeloma between 2009 and 2021, second primary malignancies adversely impacted survival outcomes in the modern era of therapeutics.
FDA Approved | Image credit: Olivier Le Moal - stock.adobe.com
September 12th 2023

FDA Approves Motixafortide Plus Filgrastim for Stem Cell Mobilization in Multiple Myeloma

Rose McNulty
The combination therapy is the first FDA approved for the mobilization of hematopoietic stem cells prior to autologous transplantation in patients with multiple myeloma.
dr jordan berlin
September 5th 2023

Dr Jordan Berlin Discusses Precision Medicine and Factoring Patient Preferences Into Treatment

Brooke McCormick
Jordan Berlin, MD, FASCO, of Vanderbilt University Medical Center, explained how patient preferences and new treatments are considered, as well as what he is currently working on and his biggest takeaway from The American Journal of Managed Care®’s Institute for Value-Based Medicine® held in Nashville, TN on August 17, 2023.
Dr Joseph Mikhael
August 28th 2023

Dr Joseph Mikhael on Strategies to Increase Diversity in Multiple Myeloma Trials

Skylar Jeremias
Joseph Mikhael, MD, MEd, FRCPC, FACP, chief medical officer of the International Myeloma Foundation, highlights several potential strategies to address the historic lack of diversity in multiple myeloma clinical trial populations.
LASZLO - stock.adobe.com
August 26th 2023

Study Suggests CAR T-Cell Therapy Safe, Effective After Allo-SCT in Multiple Myeloma

Rose McNulty
A retrospective analysis of the CARTITUDE-1 trial suggests that patients who have undergone allogeneic stem cell transplant (allo-SCT) prior to receiving chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma experience comparable outcomes to allo-SCT–naïve patients.
Dr Joseph Mikhael: Researchers, Organizations Must Collaborate to Address Disparities in Multiple Myeloma
August 23rd 2023

Dr Joseph Mikhael: Researchers, Organizations Must Collaborate to Address Disparities in Multiple Myeloma

Skylar Jeremias
Researchers and organizations must collaborate to address the persistent disparities in access to treatments for multiple myeloma, explained Joseph Mikhael, MD, MEd, FRCPC, FACP, chief medical officer of the International Myeloma Foundation.
Red FDA approved stamp on white background
August 14th 2023

FDA Approves Elranatamab for Relapsed or Refractory Multiple Myeloma

Kristi Rosa
The FDA has granted accelerated approval to elranatamab-bcmm (Elrexfio) for the treatment of adult patients with relapsed or refractory multiple myeloma who have previously received at least 4 lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
FDA approval
August 10th 2023

FDA Grants Talquetamab Accelerated Approval for R/R Multiple Myeloma

Ariana Pelosci
Patients with relapsed/refractory multiple myeloma may now receive talquetamab following the agent’s accelerated approval by the FDA.
Calendar
August 4th 2023

Later, Deeper Multiple Myeloma Treatment Responses Linked to Improved Outcomes

Rose McNulty
The study also found that patients with a later best confirmed response to therapy demonstrated improved outcomes compared with patients who experienced an early best confirmed response.
Appointment Reminder to Calendar and Organizer Agenda: © onephoto - stock.adobe.com
July 27th 2023

MM Therapy Attrition Not as High as Previously Reported

Jared Kaltwasser
Fewer patients opt to skip therapy for their multiple myeloma (MM) despite progressive disease than previously thought, a new study suggests.
Case Study Education concept. Analysis of the situation to find a solution: © Funtap - stock.adobe.com
July 25th 2023

Patient Presents With Hyperammonemia After Complete MM Remission in Rare Case

Gianna Melillo
The individual first received their multiple myeloma (MM) diagnosis in 2019.
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