Multiple Sclerosis

The AJMC® Multiple Sclerosis compendium is a comprehensive resource for clinical news and expert insights for the disabling disease that impacts the brain and spinal cord.

Latest News

The primary ofatumumab injection reaction is typically development of a fever | image credit: aardenn - stock.adobe.com
Subcutaneous Ofatumumab Shows Reduced Injection Reactions in Multiple Sclerosis

June 28th 2024

New findings show a similar number of injective-related reactions (IRRs) were reported between the use of ofatumumab (Kesimpta) and ocrelizumab (Ocrevus) in the treatment of multiple sclerosis, but less severe reactions have been associated with ofatumumab.

Currently, there is no consensus on the best diet for managing MS | image credit: nadianb - stock.adobe.com
Study Expands Knowledge on Dietary Composition and MS

June 27th 2024

Albumin is the most abundant protein in the blood | image credit: jarun011 - stock.adobe.com
More Serum Albumin, Less MS Risk?

June 26th 2024

The Mediterranean diet largely consists of higher fruit, vegetable, legume, and fish intake. | image credit: sonyakamoz - stock.adobe.com
Mediterranean Diet May Reduce Risk of Multiple Sclerosis

June 19th 2024

Gray matter is an abundant brain tissue found in the cerebellum, brain stem, and cerebrum | image credit: iushakovsky - stock.adobe.com
Gray Matter Atrophy in MS a Strong Indicator of Progression, Study Suggests

June 13th 2024

Examining the Role of a Novel Class of Medications for the Management of Multiple Sclerosis

This video series provides an in-depth look at multiple sclerosis, covering its impact, pathophysiology, treatment strategies, unmet needs, patient satisfaction, and future research. Gain key insights into managing and understanding this condition.

This video series provides an in-depth look at multiple sclerosis, covering its impact, pathophysiology, treatment strategies, unmet needs, patient satisfaction, and future research. Gain valuable insights into managing and understanding this complex condition.
Continuing Medical Education
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July 27th 2024

The Role of the Specialty Pharmacist in Optimizing Treatment for Amyotrophic Lateral Sclerosis: The Impact of Early Intervention, Patient-Centered Care, and Disease-Modifying Therapies in Slowing Disease Progression

July 31, 2024 | 1:00 PM & 8:00 PM ET
July 27th 2024

Improving Outcomes and Quality of Care in Spinal Muscular Atrophy: Updates in Treatment Advances

2.0 Credits / Neurology
July 27th 2024

New and Emerging Treatment Strategies for Myasthenia Gravis: The Role of the Specialty Pharmacist

1.0 Credit / Neurology
July 27th 2024

Improving Treatment Access for Spinal Muscular Atrophy: How Managed Care Strategies Can Ease Clinical and Caregiver Burden

1.5 Credits / Neurology
July 27th 2024

Assessing the Treatment Landscape for Multiple Sclerosis to Better Individualize Care

1.5 Credits / Neurology
July 27th 2024

Exploring Transthyretin-Mediated Amyloidosis and Its Phenotypes: A Comprehensive Approach to Patient Treatment

1.5 Credits / Cardiology, Neurology, Rare Diseases
July 27th 2024

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
July 27th 2024

Advancing Targeted Therapies Aimed at Smoldering Disease in Multiple Sclerosis

1.0 Credit / Immunology, Neurology

More News

The Role of a Hospital Pharmacist in Managing Multiple Sclerosis
April 25th 2020

The Role of a Hospital Pharmacist in Managing Multiple Sclerosis

Rachel Lutz
Gathering the opinions of hospital pharmacists regarding the treatment of multiple sclerosis can be key for successful, multidisciplinary management of the disease, according to results from a focus group.
How Has COVID-19 Changed Multiple Sclerosis Care?
April 25th 2020

How Has COVID-19 Changed Multiple Sclerosis Care?

Gianna Melillo
Online systems, including telehealth, are imperative to maintaining optimal care for patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic, said June Halper, MSN, APN-C, MSCN, FAAN, chief executive officer, Consortium of Multiple Sclerosis Centers, in an interview with The American Journal of Managed Care® (AJMC®).
New Tools Needed to Assess Dysphagia in MS, Review Says
April 19th 2020

New Tools Needed to Assess Dysphagia in MS, Review Says

AJMC Staff
Difficulty swallowing affects about one-third of patients with multiple sclerosis.
Researchers Create, Validate Health Utilization Questionnaire for Multiple Sclerosis
April 9th 2020

Researchers Create, Validate Health Utilization Questionnaire for Multiple Sclerosis

Rachel Lutz
An efficient, concise patient questionnaire gathering health utilization information is effective for patients with multiple sclerosis, according to researchers who created one.
Physical Exercise Can Reduce Fatigue in Patients With MS, Review Finds
April 1st 2020

Physical Exercise Can Reduce Fatigue in Patients With MS, Review Finds

Gianna Melillo
Physical exercise significantly reduces fatigue in patients with multiple sclerosis (MS), according to a study published in BMC Neurology.
FDA Approves Ozanimod for Patients With RMS
March 26th 2020

FDA Approves Ozanimod for Patients With RMS

Gianna Melillo
The FDA approved Bristol Myers Squibb’s ozanimod (Zeposia) 0.92 mg as an oral treatment for relapsing forms of multiple sclerosis (RMS). Ozanimod can be used to treat clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Researchers Use Virtual Reality to Detect Early MS Balance Problems
March 24th 2020

Researchers Use Virtual Reality to Detect Early MS Balance Problems

Gianna Melillo
Researchers at the University of North Carolina School of Medicine found that falls simulated through virtual reality could enable early detection of balance problems in patients with multiple sclerosis (MS), according to a study published in PLoS One.
Synthetic MRI Can Be Useful in Calculating Myelin Volume Fraction, MS Study Says
March 23rd 2020

Synthetic MRI Can Be Useful in Calculating Myelin Volume Fraction, MS Study Says

Jared Kaltwasser
A new study compares synthetic magnetic resonance imaging (SyMRI) to other techniques for measuring myelin volume fraction in patients with multiple sclerosis (MS). The data indicate the technique is effective.
Common Preservative Found in Cheese May Shape MS Disease Course
March 18th 2020

Common Preservative Found in Cheese May Shape MS Disease Course

Gianna Melillo
Propionic acid, a short-chain fatty acid, influences the multiple sclerosis (MS) disease course by an immunomodulatory mechanism, according to a study published in Cell.
Profiles Characterize Fatigue in Patients With MS
March 9th 2020

Profiles Characterize Fatigue in Patients With MS

Gianna Melillo
Fatigue profiles for patients with multiple sclerosis (MS) are based on severity of fatigue and not on various dimensions, according to a study recently published in Scientific Reports.
Multisensor Tool Accurately Measures MS Limb Dysfunction
March 3rd 2020

Multisensor Tool Accurately Measures MS Limb Dysfunction

Gianna Melillo
Researchers developed a multisensor tool that quickly and simply records motor changes in patients with multiple sclerosis (MS), according to a study recently published in Annals of Clinical and Translational Neurology. Researchers hope the introduction of the device will lead to future developments in neurological vital signs using wearable technology.
JAMA: List Prices for Key Drugs More Than Doubled Over 10-Year Period
March 3rd 2020

JAMA: List Prices for Key Drugs More Than Doubled Over 10-Year Period

Mary Caffrey
A special issue takes a wide-ranging look at the cost of prescription drugs.
Variation in Systolic BP Appears to Correlate With Multiple Sclerosis Disability
March 2nd 2020

Variation in Systolic BP Appears to Correlate With Multiple Sclerosis Disability

Jared Kaltwasser
A new study suggests patients whose systolic blood pressure varies significantly over time might be at greater risk of higher multiple sclerosis disability.
Aspects of Epstein-Barr Virus, Together and Independently, Increase Risk of MS
February 27th 2020

Aspects of Epstein-Barr Virus, Together and Independently, Increase Risk of MS

Gianna Melillo
Researchers determined 2 aspects of Epstein-Barrvirus, levels of anti–Epstein-Barr virus nuclear antigen-1 antibodies and history of infectious mononucleosis, act together and independently to increase risk of multiple sclerosis, according to a study published in Frontiers in Neurology.
Digital Tool Aims to Catch Transition to Secondary-Progressive MS
February 20th 2020

Digital Tool Aims to Catch Transition to Secondary-Progressive MS

Jared Kaltwasser
It can be difficult to notice when a patient is transitioning from relapsing-remitting multiple sclerosis to the secondary progressive form. Soon, neurologists may be able to use a digital tool to catch it.
Stem Cells Prove Effective in Treating MS Neural Damage
February 20th 2020

Stem Cells Prove Effective in Treating MS Neural Damage

Gianna Melillo
Several clinical trials have found mesenchymal stem cell therapy effective in treating neural damage in patients with multiple sclerosis (MS), according to a review published in Stem Cell Investigation.
Much of MS Cost Burden Falls on Patients' Shoulders
February 13th 2020

Much of MS Cost Burden Falls on Patients' Shoulders

Jared Kaltwasser
A British study shows nonmedical costs make up a significant portion of the annual expense generated by multiple sclerosis (MS). Most of those nonmedical costs are not covered by insurance.
Study Examines Link Between MS Survival Rate, Gastrostomy Tube Use
February 11th 2020

Study Examines Link Between MS Survival Rate, Gastrostomy Tube Use

Gianna Melillo
Patients younger than 50 years who have multiple sclerosis (MS) who receive a gastrostomy tube to enable home enteral feeding live longer than those older than 50 years, according to a study published in Multiple Sclerosis Journal- Experimental, Translational, Clinical.
Study With MS Implications Shows How Microglia Limit Macrophage Infiltration After Demyelination
February 8th 2020

Study With MS Implications Shows How Microglia Limit Macrophage Infiltration After Demyelination

Jared Kaltwasser
Scientists have long known that both microglia and blood-derived macrophages play roles in how the central nervous system responds to demyelination, which occurs in multiple sclerosis. A new study explains how the two interact.
Brain Fluid Flow Associated With MS Pathogenesis, Progression
February 5th 2020

Brain Fluid Flow Associated With MS Pathogenesis, Progression

Gianna Melillo
Researchers determined that patients with multiple sclerosis (MS) present with significant Aqueduct of Sylvius enlargement over time, which may be attributable to regional atrophy changes and ex vacuo expansion of the aqueduct, according to a study recently published in Fluids and Barriers of the CNS.
BMI, Low Vitamin D Are Independent Causal Risk Factors of MS, Study Finds
January 29th 2020

BMI, Low Vitamin D Are Independent Causal Risk Factors of MS, Study Finds

Gianna Melillo
Body mass index (BMI) and low vitamin D are causal factors for multiple sclerosis (MS), according to a recent study published in Neurology Neuroimmunology & Neuroinflammation.
Immune System Changes May Increase Efficacy of Treatment for Secondary Progressive MS
January 25th 2020

Immune System Changes May Increase Efficacy of Treatment for Secondary Progressive MS

Alison Rodriguez
Shifting towards an anti-inflammatory and suppressive homeostatic immune system may contribute to increased clinical efficacy of siponimod in patients with secondary progressive multiple sclerosis (SPMS), a recent study in JCI Insight reported.
MTX Treatment May Increase Risk of Developing Late Left Ventricular Dysfunction in Patients with MS
January 20th 2020

MTX Treatment May Increase Risk of Developing Late Left Ventricular Dysfunction in Patients with MS

Alison Rodriguez
Patients with Multiple sclerosis (MS) treated with mitoxantrone (MTX)—an antracyclin drug used to treat chronic refractory MS—may be at an increased risk of developing early and late left ventricular (LV) dysfunction, suggesting the need for these patients to be periodically evaluated for complications, a recent study found.
Researchers Develop Trial Protocol on Ketogenic and Fasting Diets for Patients With MS
January 17th 2020

Researchers Develop Trial Protocol on Ketogenic and Fasting Diets for Patients With MS

Alison Rodriguez
For patients with multiple sclerosis, ketogenic diets and fasting diets may be potentially safe and inexpensive complementary treatment options. However, additional clinical studies and data are needed to prove this theory.
Costs of MS Drugs Almost Triple in 7 Years
January 16th 2020

Costs of MS Drugs Almost Triple in 7 Years

Gianna Melillo
The costs of disease-modifying drugs for patients with multiple sclerosis (MS) have almost tripled in 7 years, even with the introduction of generic options in the market, according to a study published by Neurology, the medical journal of the American Academy of Neurology.
Exposure to IFN-beta Among Pregnant Patients With MS Poses No Risk to Infant Size, Study Says
January 8th 2020

Exposure to IFN-beta Among Pregnant Patients With MS Poses No Risk to Infant Size, Study Says

Gianna Melillo
The use of interferon-beta (IFN-beta) by pregnant patients with multiple sclerosis poses no risk to an infant’s birth weight, length, or head circumference, according to a recent study.
Researchers Investigate Novel Paradigm Connecting MS to Hygiene Hypothesis, Microbiome
January 5th 2020

Researchers Investigate Novel Paradigm Connecting MS to Hygiene Hypothesis, Microbiome

Alison Rodriguez
Researchers recently developed a novel paradigm that connects the pathophysiology of multiple sclerosis (MS) to the hygiene hypothesis and the microbiome.
Immediate Disease-Modifying Therapy After Relapse Reduces MS Disability
January 5th 2020

Immediate Disease-Modifying Therapy After Relapse Reduces MS Disability

Alison Rodriguez
The results suggest that delaying initiation of disease-modifying therapy (DMT), especially after a poorly recovered relapse, decreases the likelihood of remaining disability free by age 45.
Dr Andrew Solomon Details Conditions Commonly Misdiagnosed as MS
January 4th 2020

Dr Andrew Solomon Details Conditions Commonly Misdiagnosed as MS

There are numerous conditions, including many rare and difficult to recognize disorders, which can be mistaken for MS, said Andrew Solomon, MD, associate professor of neurological sciences and division chief of multiple sclerosis at Larner College of Medicine, The University of Vermont, Burlington, Vermont.
Dr Thomas Frisell Discusses Cardiovascular Disease Risk for Patients With MS
December 30th 2019

Dr Thomas Frisell Discusses Cardiovascular Disease Risk for Patients With MS

Thomas Frisell, PhD, coordinator of the Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden, discusses whether patients with multiple sclerosis (MS) have an elevated risk for cardiovascular disease.
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