Oncology

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The investigators found that tumor mutational burden and PD-L1 expression, which have traditionally been used as indicators of immunotherapy efficacy, had little predictive value for survival in this cohort. | Image credit: Dragana Gordic - stock.adobe.com
Predictive Model Forecasts Advanced NSCLC Outcomes

August 14th 2025

The newly developed model has an area under the curve of 0.807 for predicting progression-free survival.

Dordaviprone is indicated for recurrent H3 K27M-mutant diffuse midline glioma, an ultra-rare, aggressive brain tumor primarily affecting children. | Image credit: wladimir1804 - stock.adobe.com
FDA Approves Dordaviprone as First and Only Treatment for Aggressive Form of Glioma

August 6th 2025

Gen Li, PhD, MBA, president and founder of Phesi
Real-World Data, Digital Patient Profiles Are Revolutionizing Trial Design, Patient Recruitment: Gen Li, PhD, MBA

August 4th 2025

Value-based care. | Image Credit: irissca - stock.adobe.com
Legal Navigation Services Key to Addressing Disparities in Cancer Care

July 31st 2025

Radiotherapy can work synergistically with immunotherapy by reprogramming the tumor microenvironment. | Image credit: Crystallight-stock.adobe.com
Brain Radiotherapy Plus ICIs Boost Survival in SCLC With Brain Metastases

July 30th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations
Continuing Medical Education
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August 15th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
August 15th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

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September 7th 2015

Watch and Wait Feasible in Nearly 70% of Men With Prostate Cancer, Study Suggests

Surabhi Dangi-Garimella, PhD
Urologists analyzing data from prostate cancer patients suggest wait and watch in well-informed low-risk prostate cancer patients.
Dr Robert Dubois Outlines the Creation, Utilization of Clinical Pathways
September 6th 2015

Dr Robert Dubois Outlines the Creation, Utilization of Clinical Pathways

A survey of groups using and developing clinical pathways revealed 7 distinct themes that highlight how these pathways are created and used, and the challenges and barriers to creating new pathways, explained Robert Dubois, MD, PhD, chief science officer and executive vice president of the National Pharmaceutical Council.
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September 4th 2015

Integrating Genomics into Pediatric Cancer Care

Surabhi Dangi-Garimella, PhD
Study provides proof that a child's genetic makeup can provide actionable information to alter cancer treatment regimens.
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September 3rd 2015

Long-Anticipated Biosimilar From Novartis Launched, but at What Price?

Surabhi Dangi-Garimella, PhD
Novartis has announced that Zarxio will be available at 15% of the cost of its reference product Neupogen.
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September 3rd 2015

Prophylactic Breast Surgery on the Rise in Men With Breast Cancer

Surabhi Dangi-Garimella, PhD
Men are opting for preventive breast surgery when diagnosed with unilateral invasive disease, a study published in JAMA Surgery has found.
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September 2nd 2015

Telehealth Intervention Can Overcome Barriers to Colorectal Screening

Surabhi Dangi-Garimella, PhD
Personalized telephone counseling and tailored educational materials can improve colonoscopy rates among at-risk family members of patients with colorectal cancer.
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September 2nd 2015

Rolapitant Gains FDA Approval for CINV

AJMC Staff
Rolapitant was approved to prevent delayed phase chemotherapy-induced nausea and vomiting in adult patients.
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September 1st 2015

ASCO Publishes Policy Update on Genomic Testing for Cancer Susceptibility

Surabhi Dangi-Garimella, PhD
The Cancer Prevention and Ethics Committees of the American Society of Clinical Oncology have made several recommendations that address genetic and genomic testing policies for cancer risk assessment.
Mary Lou Smith on Ensuring Patients' Voices Are Heard
September 1st 2015

Mary Lou Smith on Ensuring Patients' Voices Are Heard

Sometimes patients are so concerned with being good patients that they simply agree to what the clinician has said without fully understanding, and it's important to ask questions and ensure their voices are heard, said Mary Lou Smith, MBA, co-founder of the Research Advocacy Network.
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September 1st 2015

Elotuzumab Accepted for Priority Review by FDA for Previously-Treated Patients With Multiple Myeloma

Surabhi Dangi-Garimella, PhD
The submission by BMS includes results from the ELOQUENT-2 trial that were recently published in the New England Journal of Medicine.
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August 31st 2015

Gene Signature Could Predict Development of Pancreatic Cancer, Allow Personalized Treatment

Surabhi Dangi-Garimella, PhD
A novel microRNA gene signature could guide earlier intervention in pancreatic cancer.
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August 31st 2015

ASCO Updates Guidelines for Advanced Lung Cancer

Surabhi Dangi-Garimella, PhD
An expert panel of ASCO developed recommendations for advanced lung cancer treatment after reviewing published literature.
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August 31st 2015

New 340B Draft Guidance May Increase Bureaucracy

Surabhi Dangi-Garimella, PhD
The new guidance released by HRSA proposes to improve oversight over the drug pricing program.
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August 30th 2015

Pharmacy Cost Trends Expected to Continue in the Double Digits

AJMC Staff
Pharmacy cost trends are expected to increase 10% up from 6.3% the year before, with specialty pharmacy trends experiencing the largest increases, according to a survey from Aon Health.
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August 28th 2015

Protein Biomarker Can Predict Response to FOLFIRINOX in Pancreatic Cancer

Surabhi Dangi-Garimella, PhD
The study published in JNCI has identified CES2 expression as a predictor of response to FOLFIRINOX.
Jennifer Malin, MD, Explains Payer Role In Changing Cancer Care
August 28th 2015

Jennifer Malin, MD, Explains Payer Role In Changing Cancer Care

While the shift to cancer becoming more of a chronic disease does not have a huge change on the approach of the payer, there are some new challenges to address, said Jennifer Malin, MD, medical director for oncology at Anthem.
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August 27th 2015

Childhood Cancer Increases Risk of Recurrent Stroke

Surabhi Dangi-Garimella, PhD
Published in the journal Neurology, the study identified childhood cancer, along with hypertension and age, as a risk factor for recurrent stroke.
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August 27th 2015

A New Decision Support Tool for Surgical Oncology Launched

AJMC Staff
A pathways company has followed up its medical and radiation oncology clinical decision tools with a new surgical oncology platform.
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August 26th 2015

As Date for First Biosimilar to Hit the Market Draws Close, Reimbursement Remains Fuzzy

Surabhi Dangi-Garimella, PhD
The Biosimilars Council wants CMS to hold back on Medicare Part B reimbursement for biosimilars.
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August 26th 2015

Do Survivorship Care Plans Improve PROs Among Cancer Patients?

Surabhi Dangi-Garimella, PhD
An article published in the Journal of Clinical Oncology finds that survivorship care plans may not greatly improve patient satisfaction with their care.
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August 25th 2015

Colorectal Cancer Screening Gets Special Look in AJMC Papers

The deadly nature of colorectal cancer merited attention in the Affordable Care Act, which called for eliminating cost-sharing for screening to prevent deaths. The future of colorectal screening, its cost-effectiveness, and a possible way to limit unneeded tests are the topic of a recent series of papers in The American Journal of Managed Care.
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August 25th 2015

Study Shows Promise for EHR-Based Algorithm in Reducing Cancer Diagnostic Delays

Surabhi Dangi-Garimella, PhD
A trigger built in patient EHRs can avoid follow-up delays in those at risk for developing certain types of cancers, a JCO study shows.
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August 25th 2015

A Payer-Provider Collaboration to Add Value to Oncology Care

Surabhi Dangi-Garimella, PhD
Aetna and the University of Chicago Medicine kicked off a value-based oncology medical home model in July this year in an effort to transition from fee-for-service to value-based care.
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August 24th 2015

Another Cancer Drug Pricing Tool, This Time From NCCN

Surabhi Dangi-Garimella, PhD
The National Comprehensive Cancer Network has announced the development of another "price" calculator that will help stakeholders assess the relative "value" of available options.
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August 21st 2015

New Study Unravels Link Between Obesity and Breast Cancer

Surabhi Dangi-Garimella, PhD
The study published in Science Translational Medicine found that tissue stiffening in the breasts of obese women can drive the development of malignant disease.
Dr Veena Shankaran Encourages Patient-Physician Communication of Care Costs
August 20th 2015

Dr Veena Shankaran Encourages Patient-Physician Communication of Care Costs

There are many cost-related pieces in the grand picture of care that are devastating to families and patients, including copayments, hospital visit bills, transportation fees, and drug prices.
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August 20th 2015

Phase 2 Basket Trial Results Claim Success in BRaf V600-Mutated Cancers

Surabhi Dangi-Garimella, PhD
Conducted by researchers at the Memorial Sloan Kettering Cancer Center, phase 2 results from a basket trial evaluated the efficacy of vemurafenib on nonmelanoma BRaf V600-mutated cancers in 122 patients across 23 global centers.
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August 18th 2015

Pilot of Decision Support to Individualize Colorectal Cancer Screening Recommendations

Amy R. Schwartz, MD Forrest L. Levin, MS Joseph A. O'Neil, Jr, BS R. Scott Braithwaite, MD, MSc
Colorectal cancer screening involves balancing immediate harms with longer-term benefits; electronic medical record decision support may facilitate personalized benefit/harm assessment.
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August 16th 2015

The Evolving Treatment Landscape and Innovative Payment Models in Oncology: An Expert Summit

This supplement summarizes proceedings from the AJMC Oncology Stakeholders Summit, Spring 2015 series, at which experts gathered to discuss the evolving treatment landscape in oncology and the development of innovative payment models to help reduce the cost of care without sacrificing quality of care.
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August 16th 2015

Special Issue Looks at What's Ahead in Precision Medicine

New resources are being directed toward precision medicine, particularly in cancer care. With that in mind, Evidence-Based Oncology, a publication of The American Journal of Managed Care, devotes its current issue to articles and commentaries on this growing field.
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