Oncology

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The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com
C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

June 7th 2025

The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com
Novel Biomarkers May Inform Prognosis in SCLC

June 6th 2025

Structured exercise programs should be a part of the standard of care for colon cancer following adjuvant chemotherapy, authors of the COMMANDS study recommended. | Image credit: Drazen - stock.adobe.com
Structured Exercise Program Improves Outcomes, Quality of Life in Colon Cancer

June 6th 2025

young adult cancer | Image credit: Roswell Park Cancer Center
ASCO Sessions Explore Data and Dynamics of Early-Onset Cancer

June 6th 2025

FDA headquarters | Image Credit: - Tada Images- stock.adobe.com
5 Key FDA Approval Dates Mark a Milestone-Filled May

June 6th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

More News

Does Transcriptional Loss of HLA Cause Immunotherapy Resistance?
October 8th 2018

Does Transcriptional Loss of HLA Cause Immunotherapy Resistance?

David Bai
The development of resistance to immunotherapy is poorly understood and is detrimental to patients who relapse on multiple lines of treatment. Transcriptional downregulation of class 1 human leukocyte antigen (HLA) may contribute to the developed resistance of immunotherapies, including checkpoint inhibitors, and warrants further investigation, according to a study published in Nature Communications.
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October 7th 2018

A Comprehensive Look at Updates, Developments in NETs

Jaime Rosenberg
During a session at the North American Neuroendocrine Tumor Society annual meeting, held October 4-6 in Seattle, Washington, Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic, outlined the biggest news and updates in the treatment of neuroendocrine tumors (NETs).
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October 7th 2018

An Update on Lung NET Guidelines

Jaime Rosenberg
During a session at the North American Neuroendocrine Tumor Society (NANETS) annual meeting, held October 4-6 in Seattle, Washington, Sukhmani Padda, MD, assistant professor of medicine, Stanford University Medical Center, gave an overview of updates made to lung neuroendocrine tumor guidelines.
Dr Thorvardur Halfdanarson Outlines New, Exciting Developments in Treatment of NETs
October 7th 2018

Dr Thorvardur Halfdanarson Outlines New, Exciting Developments in Treatment of NETs

Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic, discusses peptide receptor radionuclide therapy and other new and exciting developments in the treatment of neuroendocrine tumors (NETs).
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October 6th 2018

Sequencing of Lanreotide Can Improve Outcomes in Patients With Advanced GEP-NETs

AJMC Staff
A retrospective analysis of clinical charts across multiple institutions has found that transitioning patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to receive lanreotide after octreotide can be a potential therapeutic option.
Dr Scott Paulson on Current Challenges in the NETs Treatment Landscape
October 6th 2018

Dr Scott Paulson on Current Challenges in the NETs Treatment Landscape

The biggest challenge we have right now is how to sequence all of these therapies and how to pick the right patient to sequence those treatments, explained Scott Paulson, MD, co-director of the Gastrointestinal Research Program for The US Oncology Network, medical director for the Neuroendocrine Research and Treatment Center at Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center.
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October 6th 2018

Merkel Cell Carcinoma in the United States: Prognostics and Treatment Options

Jaime Rosenberg
Narrowing in on neuroendocrine skin cancer, a session at the North American Neuroendocrine Tumor Society annual meeting October 4-6 in Seattle, Washington, took an in-depth look at prognostics and treatment options for Merkel cell carcinoma in the United States.
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October 6th 2018

Debating Best First-Line Treatment in Well-Differentiated G3 NENs

Jaime Rosenberg
During a session at the North American Neuroendocrine Tumor Society annual meeting October 4-6 in Seattle, Washington, panelists debated whether newer targeted agents should be considered for first-line treatment in well-differentiated G3 neuroendocrine neoplasms (NENs), and if the standard of care—cytotoxic therapy—should still play a role in first-line treatment.
Cancer Types Can Impact How Well Providers May Perform Under OCM
October 5th 2018

Cancer Types Can Impact How Well Providers May Perform Under OCM

Laura Joszt, MA
The type of cancer a provider treats can determine how well he or she performs under the Oncology Care Model (OCM), according to research from Avalere Health that was presented at the American Society of Clinical Oncology Quality Care Symposium.
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October 5th 2018

Examining the Benefits of Integrative Oncology, Nutrition in NETs

Jaime Rosenberg
During a session at the North American Neuroendocrine Tumor Society annual meeting October 4-6 in Seattle, Washington, panelists discussed the benefits of integrative oncology and nutrition for patients with neuroendocrine tumors.
Dr Heloisa Soares Discusses the Roles of Somatostatin Analogs in GEP-NETs
October 5th 2018

Dr Heloisa Soares Discusses the Roles of Somatostatin Analogs in GEP-NETs

Somatostatin analogs have 2 roles in gastroenteropancreatic neuroendocrine tumors (GEP-NETS): treating symptoms related to the tumors and controlling tumor growth, explained Heloisa Soares, MD, assistant professor, University of New Mexico Cancer Center-Albuquerque.
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October 5th 2018

Analysis Demonstrates Effectiveness, Patient Satisfaction With Lanreotide in GEP-NETs

Jaime Rosenberg
An interim analysis of somatostatin analog lanreotide depot presented at the North American Neuroendocrine Tumor Society annual meeting, held October 4-6 in Seattle, Washington, found that the treatment was effective in disease control and most patients were satisfied with the treatment.
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October 5th 2018

Measuring Quality of Life Among Patients With Neuroendocrine Tumors

Jaime Rosenberg
Two studies presented at the North American Neuroendocrine Tumor Society annual meeting October 4-6 in Seattle, Washington assessed different tools for determining quality of life among patients with neuroendocrine tumors (NETs).
Preventing Antimicrobial Complications, Ensuring Stewardship in Cancer Care
October 5th 2018

Preventing Antimicrobial Complications, Ensuring Stewardship in Cancer Care

Allison Inserro
This week, infectious disease specialists from different organizations are meeting in San Francisco for ID Week, an annual conference focused on many different infectious disease topics and their intersection with cancer, HIV, respiratory diseases, and more. Two abstracts presented results about what is needed to prevent complications in cancer care, one about patients with acute myeloid leukemia (AML) with prolonged neutropenia, and one examining the frequency of antimicrobial complications following initiation of palliative chemotherapy.
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October 4th 2018

Making the Leap to Prospective Risk in Value-Based Oncology Care

Mary Caffrey
The Institute for Value-Based Medicine travels to New York City to learn how technology and trust are key to making the leap to two-sided risk.
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October 4th 2018

Recent Study on Site of Care Has Severe Limitations

Lucio N. Gordan, MD Debra Patt, MD
The outpatient community oncology setting is consistently less costly for cancer treatment as opposed to the outpatient hospital setting.
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October 4th 2018

The Authors Respond and Stand Behind Their Findings

Yamini Kalidindi, MHA Jeah Jung, PhD Roger Feldman, PhD
Our study provides the first evidence on site-specific Medicare spending on chemotherapy adjusting for patient comorbid illnesses, cancer type, and other cancer-related risks.
FDA Approves Once-Weekly Dose of Kyprolis for R/R Multiple Myeloma
October 3rd 2018

FDA Approves Once-Weekly Dose of Kyprolis for R/R Multiple Myeloma

Laura Joszt, MA
A once-weekly dose of carfilzomib (Kyprolis) in combination with dexamethasone has been approved to treat patients with relapsed or refractory (R/R) multiple myeloma. The approved regimen improved progression-free survival and had a better overall response rate than a twice-weekly regimen.
Employers Take a Vested Interest in Healthcare
October 3rd 2018

Employers Take a Vested Interest in Healthcare

Employers may not look forward to purchasing healthcare, but they are in the position to transform the market. More employers are getting more involved in healthcare by championing alternative payment models and other services to their employees.
People Living With HIV Have Higher Risk of First and Second Primary Cancer Incidence
October 2nd 2018

People Living With HIV Have Higher Risk of First and Second Primary Cancer Incidence

Jaime Rosenberg
A new study has found that people living with HIV are at an increased risk of both first and second primary cancer incidence.
FDA Approves NGS-Based Test That Detects Very Low Levels of Cancer Cells in ALL or MM
October 2nd 2018

FDA Approves NGS-Based Test That Detects Very Low Levels of Cancer Cells in ALL or MM

Laura Joszt, MA
A test that uses next-generation sequencing (NGS) has been approved to detect and monitor minimal residual disease in patients with multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL).
Top 5 AJMC® Articles of September 2018
September 30th 2018

Top 5 AJMC® Articles of September 2018

Here are the top 5 articles for the month of September.
Working Toward CAR T-Cell Treatments With Fewer Side Effects
September 30th 2018

Working Toward CAR T-Cell Treatments With Fewer Side Effects

Mary Caffrey
Loyola University Chicago and Loyola Medicine announced plans this week to develop their own chimeric antigen receptor T-cells that would have less toxic side effects.
Lack of Discussion Around Cancer Treatment Costs Leads to Financial Toxicity
September 29th 2018

Lack of Discussion Around Cancer Treatment Costs Leads to Financial Toxicity

Samantha DiGrande
Earlier this week, 3 studies were released that investigated the financial difficulties seen in patients living with cancer. Such difficulties are referred to as “financial toxicity,” which was studied in patients with metastatic breast cancer and older patients, as well as the conversations about cost of care that women with breast cancer have with their physicians.
Imfinzi Plus Chemotherapy Reduced Risk of Death by One-Third in Stage III NSCLC
September 28th 2018

Imfinzi Plus Chemotherapy Reduced Risk of Death by One-Third in Stage III NSCLC

Samantha DiGrande
Earlier this week, drug manufacturer Astrazeneca announced the results from a phase 3 trial studying durvalumab (Imfinzi) among patients with stage III unresectable non­–small cell lung cancer (NSCLC) who did not have disease progression after concurrent chemoradiotherapy.
The Risk of Creating Healthcare Monopolies
September 26th 2018

The Risk of Creating Healthcare Monopolies

Burnout and Resilience Among Oncologists
September 26th 2018

Burnout and Resilience Among Oncologists

Healthcare Payment Models
September 26th 2018

Healthcare Payment Models

Oncology Care Within Integrated Delivery Networks
September 26th 2018

Oncology Care Within Integrated Delivery Networks

The Unique Case of the VA Model
September 26th 2018

The Unique Case of the VA Model

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