Oncology

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The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com

Novel Biomarkers May Inform Prognosis in SCLC

By AJMC Contributor

June 6th 2025

Structured exercise programs should be a part of the standard of care for colon cancer following adjuvant chemotherapy, authors of the COMMANDS study recommended. | Image credit: Drazen - stock.adobe.com

Structured Exercise Program Improves Outcomes, Quality of Life in Colon Cancer

By Rose McNulty

June 6th 2025

young adult cancer | Image credit: Roswell Park Cancer Center

ASCO Sessions Explore Data and Dynamics of Early-Onset Cancer

By Mary Caffrey

June 6th 2025

FDA headquarters | Image Credit: - Tada Images- stock.adobe.com

5 Key FDA Approval Dates Mark a Milestone-Filled May

By Brooke McCormick

June 6th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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March 16th 2018

Barbara Tofani: The United States Underestimated the Need for Care Coordination

Care has become very complex and it isn’t enough to just give patients information and hope they can process it on their own, said Barbara Tofani, RN, MSN, NEA-BC, administrative director of the Hunterdon Regional Cancer Center.

March 16th 2018

False-Positive Mammography and Its Association With Health Service Use

Christine M. Gunn, PhD Barbara Bokhour, PhD Tracy A. Battaglia, MD, MPH Rebecca A. Silliman, MD, PhD Amresh Hanchate, PhD

This study demonstrated that a false-positive mammogram was associated with increases in outpatient visits, but not provider referrals, for 1 year post mammogram.

March 16th 2018

Investing in the Vital Role of a Cancer Care Coordinator

Surabhi Dangi-Garimella, PhD

At the Association of Community Cancer Centers' 44th Annual Meeting & Cancer Center Business Summit, held March 14-16, 2018, in Washington, DC, panelists shared strategies that have helped their organizations adapt to value-based care while ensuring that they never lose sight of the patient at the center of it all.

March 16th 2018

Michael Reff on Medically Integrated Dispensary in Value-Based Care

Michael Reff, executive director of National Community Oncology Dispensing Association (NCODA), discusses the role of the medically integrated dispensary in the transition to value-based payment models.

March 16th 2018

AJMC® in the Press, March 16, 2018

AJMC Staff

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

March 16th 2018

Why Tom Gallo Wants to Address Burnout During His Year as ACCC President

The increasing level of frustration that Tom Gallo saw in cancer care prompted him to choose burnout as the theme for his year as president of the Association of Community Cancer Centers (ACCC).

March 16th 2018

Development and Implementation of an Academic Cancer Therapy Stewardship Program

Amir S. Steinberg, MD Anish B. Parikh, MD Sara Kim, PharmD Damaris Peralta-Hernandez, RPh Talaat Aggour, BPharm Luis Isola, MD

A cancer therapy stewardship program can be used to improve clinical quality and patient care by emphasizing the importance of value and evidence in oncology.

March 16th 2018

Changing Trends in Oncology Practice: Value-Based Care and an Empowered Patient

Surabhi Dangi-Garimella, PhD

What are the biggest drivers of change in oncology care and what needs most attention? This was the crux of the discussion during an early panel at the Association of Community Cancer Centers' 44th Annual Meeting & Cancer Center Business Summit, held March 14-16, 2018, in Washington, DC.

March 16th 2018

Dr James Hamrick Outlines Challenges of Managing Clinical Trials and Benefits of Community Practices

The increasing complexity and personalization of clinical trials are major challenges for managing clinical trials, said James Hamrick, MD, MPH, Kaiser Permanente and Flatiron Health.

March 15th 2018

The Price of Innovation When Improving Cancer Care Delivery

Surabhi Dangi-Garimella, PhD

At the Association of Community Cancer Center’s 44th Annual Meeting & Cancer Center Business Summit, March 14-16, 2018, in Washington, DC, payer and physician representatives shared the stage with the president of a cancer foundation that is striving to break the barriers that prevent easy healthcare information exchange and access to cancer care.

March 15th 2018

NCI Researchers Find Drug May Prevent Resistance in Toxin-Based Leukemia Treatment

Samantha DiGrande

A new study recently published in Proceedings of the National Academy of Sciences has identified a possible solution for improving the efficacy of moxetumomab pasudotox, or moxe, in patients with relapsed and chemotherapy-resistant acute lymphoblastic leukemia.

March 15th 2018

Improving Quality of Care in Oncology Through Healthcare Payment Reform

Lonnie Wen, RPh, PhD Christine Divers, PhD Melissa Lingohr-Smith, PhD Jay Lin, PhD, MBA Scott Ramsey, MD, PhD

Overview of alternative payment models and how leading national organizations are involved with linking quality improvement initiatives and payment reform.

March 15th 2018

Dr Ali McBride: Addressing Adherence Issues With Patient Education

Patient education is critical for improving adherence as many patients don’t always know what their medications are or even how they can be taken with other medications they area already on, said Ali McBride, PharmD, MS, BCPS, clinical coordinator for University of Arizona Cancer Center.

March 15th 2018

Steven D'Amato Outlines Strategies for Improving Adherence to Oral Oncolytics

Information technology and an integrated clinical team can help improve medication adherence for patients receiving oral oncolytics, said Steven D'Amato, RPh, BSPharm, executive director of New England Cancer Specialists.

March 14th 2018

Breast Cancer Screening Guidelines May Lead to Delayed Diagnosis in Nonwhite Women

Kelly Davio

March 13th 2018

Pembrolizumab Granted Priority Review for Treatment of Cervical Cancer

Jaime Rosenberg

The FDA has accepted a new supplemental Biologics License Application and granted Priority Review for Merck's pembrolizumab (Keytruda) for the treatment of advanced cervical cancer, marking the first filing acceptance for an anti–PD-1 therapy in cervical cancer.

March 13th 2018

Dr Linda Frisk Discusses the Role of the Pharmacist in Value-Based Care

Linda Frisk, PharmD, of Arizona Oncology, discusses the role of the pharmacist in new value-based payment models and her experience with the Oncology Care Model (OCM).

March 13th 2018

ICER Outlines Planned Review of Antiandrogen Therapies for nmCRPC

Jaime Rosenberg

The Institute for Clinical and Economic Review (ICER) is requesting public comment on 3 antiandrogen therapies for nonmetastatic castrate-resistant prostate cancer (nmCRPC): abiraterone, enzalutamide, and apalutamide.

March 12th 2018

Dr Thomas Graf on the Impact of New Therapies in Oncology

Thomas Graf, MD, chief medical officer and vice president, Horizon Blue Cross Blue Shield of New Jersey, discusses the impact of increases in drug prices on oncology stakeholders.

March 10th 2018

Podcast: This Week in Managed Care—Verma on Health Data and Other Health News

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

March 10th 2018

Dr Thomas LeBlanc: Patients With Blood Cancer and Palliative Care

Thomas LeBlanc, MD, Duke Cancer Institute, discusses the trends of hospice care services used among patients with blood cancer compared with patients with solid tumors.

March 10th 2018

Tapping Into the Health Benefits of Social Networks Among Cancer Survivors

Surabhi Dangi-Garimella, PhD

Scientists at St. Jude Children’s Research Hospital have developed a new tool to measure the impact of social networks on the coping skills of adolescent and young adult cancer survivors.

March 10th 2018

Patients With Breast Cancer or Lymphoma Have Increased Risk of Heart Failure

Kaitlynn Ely

Patients who had breast cancer or lymphoma who were treated more than 3 times are more likely to develop congestive heart failure than those who did not have cancer, according to research being presented at the American College of Cardiology’s 67th Annual Scientific Session.

March 9th 2018

This Week in Managed Care: March 9, 2018

This week, the top managed care stories included Cigna's deal to buy Express Scripts; Seema Verma, Alex Azar, and Scott Gottlieb, MD, made the rounds at health conferences; an analysis finds FDA's accelerated approval pathway has been a success with hematology and oncology drugs.

March 8th 2018

Dr Adam Brufsky Outlines Care Coordination in Oncology

Care coordination is vital to ensure improved patient outcomes as both CMS and private payers are paying increased attention to it, pointed out Adam Brufsky, MD, PhD, co-director of the Comprehensive Breast Cancer Center at University of Pittsburgh. How is your institution infusing care coordination in its workflow?

March 8th 2018

Expedited Approval Is Successful for Cancer Therapies, FDA Says

Kelly Davio

Reviewing 25 years of experience with accelerated approvals (AAs) for malignant hematology and oncology drugs and biologics, FDA officials say that the AA program has demonstrated that it can be used successfully to expedite approval of safe, effective cancer therapies that balance uncertainty with the need to provide faster access to promising agents for serious and life-threatening diseases.

March 8th 2018

Science 37, Novartis Sign Agreement to Advance Decentralized Clinical Trials

AJMC Staff

Proprietary technology helps overcome the problem of long travel distances for those taking part in clinical trials.

March 7th 2018

FDA Authorizes Direct-to-Consumer Test That Reports on 3 BRCA Mutations

Jaime Rosenberg

The FDA has authorized, with special controls, the first direct-to-consumer test that reports on 3 specific BRCA1/BRCA2 breast cancer gene mutations that are most common in people of Ashkenazi (Eastern European) Jewish descent.

March 7th 2018

Impact of Trained Oncology Financial Navigators on Patient Out-of-Pocket Spending

Todd Yezefski, MD Jordan Steelquist, BA Kate Watabayashi, BA Dan Sherman, MA Veena Shankaran, MD

Hospitals that used trained financial navigators were able to provide financial assistance for their patients with cancer, providing access to care that would otherwise be unaffordable.

March 4th 2018

CSPG4 Could Make CAR T-Cell Therapy a Reality in Treating Glioblastoma

Kelly Davio

Researchers have identified a molecular target that could allow chimeric antigen receptor (CAR) T-cell therapy to be used in treating patients with glioblastoma. Although the heterogeneous expression of tumor-associated antigens limits the efficacy for CAR-redirected T cells for the treatment of glioblastoma, chondroitin sulfate proteoglycan 4 (CSPG4), a cell surface type 1 transmembrane protein, is highly expressed in a majority of glioblastoma specimens with limited heterogeneity.

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