Oncology

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The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com

Novel Biomarkers May Inform Prognosis in SCLC

By AJMC Contributor

June 6th 2025

Structured exercise programs should be a part of the standard of care for colon cancer following adjuvant chemotherapy, authors of the COMMANDS study recommended. | Image credit: Drazen - stock.adobe.com

Structured Exercise Program Improves Outcomes, Quality of Life in Colon Cancer

By Rose McNulty

June 6th 2025

young adult cancer | Image credit: Roswell Park Cancer Center

ASCO Sessions Explore Data and Dynamics of Early-Onset Cancer

By Mary Caffrey

June 6th 2025

FDA headquarters | Image Credit: - Tada Images- stock.adobe.com

5 Key FDA Approval Dates Mark a Milestone-Filled May

By Brooke McCormick

June 6th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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August 31st 2017

Pembrolizumab Plus Epacadostat Yields Durable Response in Advanced Melanoma: ESMO

Surabhi Dangi-Garimella, PhD

Results of a combination trial evaluating epacadostat with pembrolizumab in advanced melanoma, to be presented at the upcoming European Society for Medical Oncology (ESMO) 2017 Congress, has found that the treatment is well tolerated and has promising clinical activity.

August 30th 2017

Race, Socioeconomic Status Linked to Rehospitalizations Among Patients With Advanced Cancer

Christina Mattina

A new study finds that individuals with advanced cancer have high rates of hospitalization in the year after diagnosis. Palliative care aimed at preventing hospital admissions may be a useful tool, especially for the populations most at risk of rehospitalization.

August 30th 2017

FDA Approves Tisagenlecleucel, the First CAR-T Cell Therapy in the United States

Laura Joszt, MA

The FDA has approved the first chimeric antigen receptor-T (CAR-T) treatment, tisagenlecleucel (Kymriah), for the treatment of B-cell precursor acute lymphoblastic leukemia in certain pediatric and young adult patients. The therapy represents a new frontier in cancer care.

August 29th 2017

FDA Approves Expanded Use of Fulvestrant as First-Line Hormonal Breast Cancer Therapy

Christina Mattina

AstraZeneca announced that the FDA has expanded the indications for fulvestrant (Faslodex). The drug is now approved as first-line monotherapy for women with certain types of breast cancer.

August 28th 2017

Ancestry Determines Effective and Harmful Dose in Breast Cancer

Surabhi Dangi-Garimella, PhD

A study published in JCO Precision Oncology has identified an association between genetic inheritance and patients’ response to efficacy and toxicity in the phase 3 ECOG-ACRIN-5103 trial.

August 25th 2017

Case Study Identifies New Trigger for CAR-T Cell Expansion in DLBCL in JCAR017 Trial

Surabhi Dangi-Garimella, PhD

Chimeric antigen receptor (CAR)-T cells can re-expand in a lymphoma patient months after the initial infusion and can also be active against the patient’s cancer, according to a new study.

August 25th 2017

High-Dose Vitamin B Supplements Linked to Lung Cancer Risk in Men, Particularly Smokers

Christina Mattina

A new study points to an association between use of high-dose vitamin B6 and B12 supplements and an increased risk of lung cancer in men, especially in those who smoke.

August 24th 2017

Study Finds HPV Vaccination Underutilized by Childhood Cancer Survivors

Surabhi Dangi-Garimella, PhD

A new study in the Journal of Clinical Oncology identifies an increased role for physicians in boosting human papillomavirus (HPV) vaccination rates among childhood cancer survivors to reduce their risk of a second cancer.

August 23rd 2017

End-of-Life Palliative Care Lowered Utilization for Patients With Cancer

Christina Mattina

A new study indicates that palliative care can significantly reduce end-of-life hospitalizations and aggressive procedures among Medicare beneficiaries with advanced cancer.

August 23rd 2017

What Is the Ideal Age for Screening Mammography?

Surabhi Dangi-Garimella, PhD

According to a new study published in Cancer, an annual screening mammogram starting at age 40 has the greatest impact on reducing mortality.

August 21st 2017

Financial Concerns Influence Care-Seeking Behavior of Childhood Cancer Survivors

Surabhi Dangi-Garimella, PhD

High out-of-pocket (OOP) medical costs in survivors of childhood cancer can influence their treatment choices and care-related behavior, and ultimately affect their health outcomes, according to a study published in the Journal of Clinical Oncology.

August 21st 2017

FDA Approves Besponsa for Relapsed/Refractory Acute Lymphoblastic Leukemia

Alison Rodriguez

The FDA has approved Besponsa (inotuzumab ozogamicin) for treating adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia.

August 18th 2017

Phase 1 Trial Indicates Pembrolizumab Safe in Aggressive Small-Cell Lung Cancer

Christina Mattina

A small phase 1b trial of pembrolizumab in patients with small-cell lung cancer shows that the immunotherapy drug had a favorable safety profile and demonstrated “promising” antitumor activity.

August 17th 2017

Noninvasive ctDNA Test Sensitive to Early-Stage Cancer

Surabhi Dangi-Garimella, PhD

Researchers from the United States, Netherlands, and Denmark have collaborated on developing a new liquid biopsy test that can detect circulating cell-free DNA in patients with early-stage cancer.

August 16th 2017

Small Study Confirms Feasibility of a Personalized Neoantigen Vaccine for Melanoma

Surabhi Dangi-Garimella, PhD

A new study, published in the journal Nature, has confirmed the efficacy of a melanoma vaccine targeted against 20 predicted personal tumor neoantigens in 6 patients.

August 16th 2017

Persistent Neuropathy After Chemotherapy Leads to Falls, Disability in Women

Christina Mattina

Following completion of their chemotherapy regimen, many women who have survived cancer experience lingering symptoms of chemotherapy-induced peripheral neuropathy, according to a new study.

August 15th 2017

Cancer Drug Price Increases Cost Medicaid Millions in Extra Spending, Analysis Shows

Christina Mattina

An analysis by Kaiser Health News found that Medicaid incurred billions of dollars in extra spending as a result of price increases for hundreds of common drugs from 2015 to 2016, including decades-old branded drugs and generics used to treat cancer.

August 15th 2017

Short-Term CV Risk in Patients With Newly Diagnosed Cancer

Surabhi Dangi-Garimella, PhD

A retrospective study in patients with newly diagnosed cancer has identified an increased risk of cardiovascular (CV) abnormalities that are aggravated by cancer stage.

August 15th 2017

Dr Lee Newcomer on UnitedHealthcare's Value-Based Contracts

UnitedHealth is currently involved in 2 types of value-based contracts with its provider partners, but it has seen more success with one compared with the other, explained Lee N. Newcomer, MD, MHA, senior vice president of oncology and genetics at UnitedHealthcare.

August 14th 2017

The American Journal of Managed Care® to Host the 2017 Patient-Centered Oncology Care® Meeting

This meeting presents unique perspectives on emerging topics in managed care from today’s leading experts

August 14th 2017

Targeted Therapies: One Practice's Story

Barry Kaplan, MD, PhD

A community oncologist's perspective on the advantages and challenges with precision medicine.

August 14th 2017

Letter to the Editors

Eleanor M. Perfetto, PhD, MS

A reaction to Institute for Clinical and Economic Review's value assessment framework by Eleanor M. Perfetto, PhD, MS, of The National Health Council.

August 14th 2017

Lower SES Survivors Less Likely to Receive Reconstruction Post Mastectomy

Christina Mattina

A new study indicates there are persistent socioeconomic disparities in the rates of women who receive breast reconstruction surgery after undergoing a mastectomy to treat their breast cancer.

August 14th 2017

Matching PROs With Medical Records to Assess Comorbidities in Prostate Cancer

Surabhi Dangi-Garimella, PhD

Patient reported data can be a reliable source of information to ascertain comorbidities in patients with prostate cancer, says JAMA Oncology study.

August 11th 2017

How Does Underinsurance Impact Decision Making in Patients With Cancer?

Surabhi Dangi-Garimella, PhD

A study in JAMA Oncology has found that unpreparedness for treatment-related expenses among patients being treated for cancer can bear upon the patient’s future decision-making.

August 10th 2017

Genetic Counselors Save Costs Across the Genetic Testing Spectrum

Joy Larsen Haidle, MS, CGC Darci L. Sternen, MS, CGC Jane A. Dickerson, PhD Amelia Mroch, MS, CGC Denise F. Needham, MS, CGC Christine M. Riordan, MS, CGC Michele C. Kieke, PhD, MS, CGC

Genetic counselors (GCs) increasingly serve a variety of roles across the healthcare spectrum, including test utilization management. Our data show that utilizing the expertise of GCs reduced test order errors, improved patient outcomes, and resulted in significant cost savings to the healthcare system.

August 10th 2017

From "Magic Bullets" to Precision Medicine—Ensuring More Patient-Centered Cancer Care

Joseph Alvarnas, MD

As we shift to the precision-medicine model of cancer care, it is essential to develop a scalable system that can deliver these care solutions in a patient-centered, economically sustainable way.

August 10th 2017

ICER Seeks Public Comment on Scoping Document for CAR-T Treatments

Surabhi Dangi-Garimella, PhD

The Institute for Clinical and Economic Review (ICER) has released a draft version of their scoping document that will compare the clinical effectiveness and value of 2 chimeric antigen receptor (CAR)-T cell treatments being reviewed by the FDA.

August 10th 2017

Vaccine for Glioblastoma Awarded Orphan Drug Status by FDA

Christina Mattina

MimiVax announced that its immunotherapy vaccine SurVaxM, which is being tested in clinical trials for glioblastoma, has been designated an orphan drug by the FDA.

August 9th 2017

Patient Engagement Is Mandatory at Our Table

Bonnie J. Addario Daryl Pritchard, PhD

The Bonnie Addario Lung Cancer Foundation has developed a registry that can serve as a repository for data on patients with lung cancer-a means to empower patients and assist care providers to deliver personalized medicine in a patient-centered manner.

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