Oncology

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The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com

Novel Biomarkers May Inform Prognosis in SCLC

By AJMC Contributor

June 6th 2025

Structured exercise programs should be a part of the standard of care for colon cancer following adjuvant chemotherapy, authors of the COMMANDS study recommended. | Image credit: Drazen - stock.adobe.com

Structured Exercise Program Improves Outcomes, Quality of Life in Colon Cancer

By Rose McNulty

June 6th 2025

young adult cancer | Image credit: Roswell Park Cancer Center

ASCO Sessions Explore Data and Dynamics of Early-Onset Cancer

By Mary Caffrey

June 6th 2025

FDA headquarters | Image Credit: - Tada Images- stock.adobe.com

5 Key FDA Approval Dates Mark a Milestone-Filled May

By Brooke McCormick

June 6th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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February 21st 2017

Cholesterol-Lowering Medications Complement Endocrine Therapy in Breast Cancer

Surabhi Dangi-Garimella, PhD

Including anti-cholesterol agents during adjuvant endocrine treatment can prevent breast cancer recurrence in hormone receptor—positive early-stage breast cancer.

February 20th 2017

TAPUR Trial Expands Who Can Join Clinical Trials, If Payers Fund Genomic Tests

Mary Caffrey

Pam Mangat, MS, associate director for the TAPUR study in the research and analysis division of the American Society of Clinical Oncology, offered an update on the study at the 5th annual Patient-Centered Oncology CareÂ® meeting.

February 20th 2017

Developments in Immunotherapy at PCOC®: The Living Drugs

Surabhi Dangi-Garimella, PhD

David L. Porter, MD, kicked off the 5th annual Patient-Centered Oncology CareÂ® (PCOCÂ®) meeting in Baltimore on November 17, 2016, with an update on chimeric antigen receptor T-cell therapy.

February 20th 2017

Responding to Patient Needs Central to Providing Value in Cancer Care

Christina Mattina

At the 5th annual Patient-Centered Oncology CareÂ® meeting, Nell Wood Buhlman of Press Ganey explained that oncology providers must focus on patient needs and minimize suffering in order to truly provide value in cancer care.

February 20th 2017

Immunoâ€Oncology Versus Precision Medicine: Where Is Cancer Care Headed?

Surabhi Dangi-Garimella, PhD

At the 5th annual Patient-Centered Oncology CareÂ® meeting, hosted by The American Journal of Managed CareÂ®, experts discussed the contradiction presented by immuno-oncology agents in the world of precision medicine.

February 20th 2017

The Future of Oncology Care: 2017 and Beyond

Christina Mattina

Bruce A. Feinberg, DO, moderated a panel at the 5th annual Patient-Centered Oncology CareÂ® meeting that brought stakeholders together to share their cancer care predictions for the upcoming year.

February 20th 2017

Cancer Trial Participants Can Successfully Self-Report Adverse Events

Christina Mattina

Adverse events from cancer clinical trials are currently reported by trial investigators, but a recent feasibility study found that patients can successfully and accurately report their own symptoms if given the opportunity.

February 19th 2017

OlympiAD Trial Reports Success With Olaparib and Predictive Diagnostic Test

Surabhi Dangi-Garimella, PhD

The trial successfully improved progression-free survival and also tested a BRCA diagnostic test in patients with ovarian cancer.

February 19th 2017

Dr Carrie Stricker on How Carevive Integrates Patient-Reported Outcomes Into Care Planning

Carevive recognizes the importance of including patient-reported outcomes into the care planning process, so they have developed surveys that will provide patients with the resources to address those concerns, according to Carrie Stricker, PhD, RN, AOCN, chief clinical officer and co-founder of Carevive.

February 17th 2017

Pharma—PBM War on Drug Prices Picks Up Steam

Surabhi Dangi-Garimella, PhD

An e-mail, from Mark Merritt, president and CEO of the trade group Pharmaceutical Care Management Association, to the organization’s board, lays out a plan to develop an aggressive campaign to convince the new administration that the fault rests with pharmaceutical manufacturers.

February 17th 2017

This Week in Managed Care: February 17, 2017

This week, the top managed care stories included the end of 2 insurance megamergers, a proposed rule to tighten restrictions for the Affordable Care Act, and new legislation in New Jersey provides the nation's strictest mandates for treating addiction.

February 17th 2017

Pam Mangat on the Future of Surrogate Endpoints and Genetic Sequencing in Cancer Care

Surrogate endpoints could eventually add to or replace clinical endpoints in determining a cancer treatment’s effectiveness, according to Pam Mangat, MS, associate director TAPUR study at the American Society of Clinical Oncology. She also said that a deeper understanding of a patient’s genetic makeup and tumor biology in conjunction with new technologies will drive improvements in oncology care.

February 16th 2017

Advanced APMs and the Emerging Role of Immuno-Oncology Agents: Balancing Innovation and Value

Michael V. Seiden, MD, PhD Marcus Neubauer, MD Diana Verrilli

The shift to value-based care, concurrent with innovations in immune-based care, will create challenges in oncology. What should be the physician and manufacturer responsibility during these changing times?

February 16th 2017

Helping Cancer Patients and Caregivers Navigate Immunotherapy Treatment

Claire Saxton, MBA Joanne Buzaglo, PhD Sue Rochman, MA Alexandra Zaleta, PhD

Patients, caregivers, and providers need education on immunotherapy treatment, support in patient-provider communications as well as support in mitigating the financial impact of immunotherapy treatment.

February 16th 2017

Postmenopausal Weight Loss Cuts Risk of Endometrial Cancer by Half

Surabhi Dangi-Garimella, PhD

Observational findings from the Women’s Health Initiative study found that an intentional weight loss regimen by postmenopausal obese women can slash their risk of endometrial cancer by 29% to 56%.

February 16th 2017

Dr Marianne Fazen Discusses New Ways to Educate Employers on Value in Cancer Care

Through the use of workshops and other productions, the Texas Business Group on Health educates employers on how they can maximize value through oncology care innovations like precision medicine, according to Marianne Fazen, PhD, president and CEO of the Texas Business Group on Health.

February 15th 2017

UCSF Researchers Identify Determinants of Coverage for Hereditary Cancer Panels

Surabhi Dangi-Garimella, PhD

A new study published in the Journal of the National Comprehensive Cancer Network dives deeper into understanding the major roadblocks to coverage of hereditary cancer panels.

February 15th 2017

Breast Cancer Survivors Report More Cognitive Impairment After Chemotherapy

Christina Mattina

A study of breast cancer survivors’ cognitive performance before and after chemotherapy sheds light on the problem of cancer-related cognitive impairment.

February 15th 2017

From Bench to Community Oncology Clinic: The Promise of Immunotherapy

Sumeet Chandra, MD

Community oncologists will be at the forefront of using immunotherapies and will need to be strong advocates for greater information and affordability of therapies.

February 15th 2017

Managing Patient Expectations With Immuno-Oncology

Surabhi Dangi-Garimella, PhD

Immunotherapy treatments are not without side effects. What do patients and their families need to know so they are more aware?

February 15th 2017

Dr Karen van Caulil Says Employers Will See Value of OCM

Employers are generally not very familiar with the Oncology Care Model (OCM) yet, but support will grow as they see that the key goals of the OCM overlap with their own concerns, predicted Karen van Caulil, PhD, president and CEO of the Florida Health Care Coalition.

February 14th 2017

CAR-T Cells: The Next Era in Immuno-Oncology

Bruce A. Feinberg, DO Jennifer Fillman, MBA Justin Simoncini, MBA, MPH Chadi Nabhan, MD, MBA, FACP

An update on immunotherapies and the potential impact of chimeric antigen receptor (CAR)-T cells on oncology care.

February 14th 2017

Sustained Response to Immune Checkpoint Inhibitors Could Influence Standard of Care

Surabhi Dangi-Garimella, PhD

A new study to be presented at the 2017 Genitourinary Cancers Symposium has found that some patients with advanced renal cell carcinoma had a durable response after treatment discontinuation.

February 14th 2017

Patient Navigation in Immuno-Oncology

Shawn M. Regis, PhD

Patient navigation is immensely helpful in relieving some of the burden placed on cancer patients, and there are some particularly unique aspects of navigation as it pertains to immuno-oncology.

February 13th 2017

AJMCtv® Interviews, February 2017

Nicole Beagin Laura Joszt, MA

AJMCtvÂ® interviews let you catch up with experts in healthcare. Topics include challenges with immuno-oncology, including the patient voice in treatment decisions, and why payers should cover genomic testing.

February 13th 2017

Navigator Program Lowered Costs, Utilization for Elderly Cancer Patients

Christina Mattina

A program linking elderly cancer patients to lay navigators was shown to substantially reduce costs and decrease hospitalizations, making it an appealing tool for providing value-based oncology care.

February 13th 2017

Predicting Response to SCT in Patients With MDS

Surabhi Dangi-Garimella, PhD

A new study has identified key mutations that can direct the conditioning regimen prior to an allogenic hematopoietic stem cell transplant (SCT) in patients with myelodysplastic syndrome (MDS), leading to a better response.

February 13th 2017

Debra Madden Discusses Importance of Educating Patients on Immuno-Oncology Risks

Immuno-oncology is often portrayed as having less severe side effects than chemotherapy, but patients need to be aware that it does carry some risks, said Debra L. Madden, cancer research advocate and patient representative. Patients should not hesitate to report any adverse effects to their doctor.

February 12th 2017

MD Anderson Now an Oncology "Superhub" for Project ECHO

Surabhi Dangi-Garimella, PhD

MD Anderson Cancer Center, which first established its oncology-focused ECHO program in 2014 has now adopted a much bigger role, of a “superhub.”

February 11th 2017

Podcast: This Week in Managed Care - Drop in ACA Enrollment, and Other News

Every week, The American Journal of Managed CareÂ® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

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