Oncology

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The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com

Novel Biomarkers May Inform Prognosis in SCLC

By AJMC Contributor

June 6th 2025

Structured exercise programs should be a part of the standard of care for colon cancer following adjuvant chemotherapy, authors of the COMMANDS study recommended. | Image credit: Drazen - stock.adobe.com

Structured Exercise Program Improves Outcomes, Quality of Life in Colon Cancer

By Rose McNulty

June 6th 2025

young adult cancer | Image credit: Roswell Park Cancer Center

ASCO Sessions Explore Data and Dynamics of Early-Onset Cancer

By Mary Caffrey

June 6th 2025

FDA headquarters | Image Credit: - Tada Images- stock.adobe.com

5 Key FDA Approval Dates Mark a Milestone-Filled May

By Brooke McCormick

June 6th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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November 21st 2016

PCOC16: Immunoâ€Oncology Agents in a World of Precision Medicine

Surabhi Dangi-Garimella, PhD

At the 5th annual meeting of Patient-Centered Oncology CareÂ®, hosted by The American Journal of Managed Care, November 17-18 in Baltimore, Maryland, experts with diverse experiences and backgrounds discussed the contradiction presented by immuno-oncology agents in the world of precision medicine.

November 20th 2016

End of ACA Won't Stop March Toward Value-Based Care, Experts Say

President-elect Donald J. Trump’s upset win almost certainly means the end of the Affordable Care Act (ACA) as we know it, but experts who spoke at Patient-Centered Oncology Care Thursday and Friday said the movement toward value-based payment will continue. The fifth annual meeting, presented by The American Journal of Managed Care, took place in Baltimore, Maryland.

November 19th 2016

This Week in Managed Care: November 19, 2016

This week, the top managed care news included president-elect Donald Trump outlining parts of Obamacare he would be willing to keep, lawmakers confirming they still want to pass the 21st Century Cures Act, and the FDA held a 2-day hearing on off-label use.

November 19th 2016

Dr Bruce Feinberg: PCOC Has the Greatest Depth and Breadth

What makes Patient-Centered Oncology Care stand out from other meetings is the equal representation among all stakeholders, which gives the meeting a unique depth, said Bruce Feinberg, DO, vice president and chief medical officer at Cardinal Health Specialty Solutions.

November 18th 2016

Chronic Conditions May Be Barrier to Timely Cervical Cancer Screening

Christina Mattina

A survey examining nonfinancial barriers to cervical cancer screening indicated that women who were rarely or never screened were more likely to report having 1 or more chronic conditions. The study suggests that physicians include preventive services along with treatment for chronic conditions.

November 18th 2016

Sanofi Pasteur Announces It Will Discontinue Its Bladder Cancer Vaccine

AJMC Staff

Sanofi Pasteur has announced that it has decided to discontinue production of the BCG vaccine, which is indicated for the treatment and prophylaxis of carcinoma in situ of the urinary bladder.

November 17th 2016

ICU Admission Reduces Survival, Augments Costs Among Patients With AML

Surabhi Dangi-Garimella, PhD

A study published by researchers from the Fred Hutchinson Cancer Research Center in Seattle has found that admission to the intensive care unit reduced survival and increased the cost of care among patients undergoing treatment for acute myeloid leukemia.

November 17th 2016

Addressing the Psychosocial Needs in Older Breast Cancer Patients

Surabhi Dangi-Garimella, PhD

A study conducted in Canada to estimate the prevalence of psychotropic and opioid medication use by older women diagnosed with breast cancer found a significant increase in use, especially during the active treatment phase.

November 16th 2016

First-in-Human Trial of CRISPR-Cas9 Begins in Lung Cancer Patients

Surabhi Dangi-Garimella, PhD

A hospital in China has made history by injecting a patient with lung cancer with revolutionary, yet controversial, CRISPR-Cas9—edited T cells. The first patient was injected on October 28.

November 15th 2016

BLA for Bevacizumab Biosimilar Filed Based on Phase 3 NSCLC Data

Surabhi Dangi-Garimella, PhD

Amgen and Allergan have announced that they have submitted a Biologics License Application (BLA) for ABP 215, a biosimilar to bevacizumab (Avastin).

November 15th 2016

Combining IORT With Chemotherapy Improves Survival in Pancreatic Cancer

Surabhi Dangi-Garimella, PhD

A new study conducted at the Massachusetts General Hospital evaluated the impact of intraoperative radiotherapy (IORT), along with induction chemotherapy and chemo-radiotherapy, in patients with advanced disease, and observed hints of success.

November 14th 2016

Prospective Trial Confirms Important Role of Vitamin D in Breast Cancer

Surabhi Dangi-Garimella, PhD

A prospective trial among breast cancer patients enrolled in The Pathways Study has found that higher levels of vitamin D can lower the risk of breast cancer morbidity and mortality.

November 12th 2016

Genetic Factors Can Help Tailor Surveillance Programs for Melanoma

Surabhi Dangi-Garimella, PhD

A study conducted in Australia has concluded that a person’s inherited risk factors for melanoma should be considered when developing self-examination and surveillance programs.

November 11th 2016

The Fate of Cancer Moonshot in 2017

Surabhi Dangi-Garimella, PhD

Will Vice President Joe Biden's Cancer Moonshot initiative be able to sustain it's momentum in 2017 following the transition in government?

November 10th 2016

Nivolumab Approved in Patients With Recurrent SCCHN

AJMC Staff

The FDA today granted approval to the programmed death ligand-1 inhibitor, nivolumab (Opdivo), for treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN), following platinum-based treatment.

November 10th 2016

Medical Home Transformation and Breast Cancer Screening

Amy W. Baughman, MD, MPH Phyllis Brawarsky, MPH Tracy Onega, PhD, MS Tor D. Tosteson, ScD Qianfei Wang, MS Anna N.A. Tosteson, ScD Jennifer S. Haas, MD, MSc

Breast cancer screening may not improve in early medical home implementation.

November 10th 2016

US Cigarette Smoking Rate Sees a 5% Decrease Since 2005

Surabhi Dangi-Garimella, PhD

According to CDC’s Morbidity and Mortality Weekly Report, the cigarette smoking rate of adults in the United States has seen a significant drop during the decade from 2005 to 2015.

November 10th 2016

ASCO Upgrades Guidelines to Include Palliative Care in Standard Oncology Care

Surabhi Dangi-Garimella, PhD

The American Society of Clinical Oncology’s Ad Hoc Palliative Care Expert Panel has developed specific evidence-based recommendations for access to palliative care services for individuals with advanced cancer and for their family caregivers.

November 9th 2016

How Do Distress Tests Impact Cancer Care Providers?

Surabhi Dangi-Garimella, PhD

A study published in the Journal of the National Comprehensive Cancer Network has found that screening for distress tests improves provider confidence and awareness toward person-centered care.

November 9th 2016

Soda Taxes Pass in Four Cities, But Tobacco Votes Are Mixed

Mary Caffrey

Three of the 4 cities to pass taxes on soda are in Northern California, not far from Berkeley, which passed the nation's first soda tax in 2014.

November 8th 2016

New Digital Tool to Compare Insurance Coverage for Cancer Screening Tests

Surabhi Dangi-Garimella, PhD

The Prevent Cancer Foundation has developed a digital tool that can compare coverage of screening tests for breast, cervical, colorectal, lung, and prostate cancers across health insurance plans available in a specific state.

November 8th 2016

Humana's Roy A. Beveridge, MD, to Give Keynote at Patient-Centered Oncology Care

With value-based reimbursement now far from its infancy, the chief medical officer for Humana will forecast what’s ahead in payment reform-and how oncology connects with what is happening in primary care, hospitals, and the pharmaceutical industry. Roy A. Beveridge, MD, will open Patient-Centered Oncology Care, which will meet November 17-18, 2016, in Baltimore, Maryland.

November 7th 2016

Meta-Analysis Confirms Clinical Advantage of BRAF/MEK and PD-1 Inhibitors in Melanoma

Surabhi Dangi-Garimella, PhD

Based on a retrospective meta-analysis of clinical trial data, authors of a recent paper in JAMA Oncology concluded that BRAF/MEK and programmed death receptor-1 (PD-1) inhibitors were the most effective treatments that were relatively safe in melanoma.

November 7th 2016

Value of Second Opinion in Prostate Cancer Uncertain, Says Hopkins Study

Surabhi Dangi-Garimella, PhD

A new study by researchers at the Johns Hopkins University has found that second opinions did not change treatment choice among men diagnosed with low-risk prostate cancer.

November 4th 2016

A Diagnostic Tool for Cachexia in Cancer Patients Could Save Lives

Surabhi Dangi-Garimella, PhD

Researchers from Canada’s McGill University have developed a potential tool that can detect early signs of cachexia in cancer patients, which could impact survival.

November 4th 2016

Genetic Counseling Prerequisite Reduced Appropriate Testing, Study Finds

Surabhi Dangi-Garimella, PhD

A new study in the Journal of Oncology Practice has found that the health plan requirement of counseling by certified geneticists could have led to patient access issues in oncology.

November 3rd 2016

ASCO's Collaboration Will Expand the Reach of COME HOME for Oncology Patients

Surabhi Dangi-Garimella, PhD

The American Society of Clinical Oncology (ASCO) has announced that it is collaborating with Innovative Oncology Business Solutions, Inc, on ASCO COME HOME.

November 3rd 2016

Segment 8 - Covering the Gaps in Cancer Survivor Care

How can care providers ensure cancer survivors continue to receive adequate follow-up care post treatment?

November 3rd 2016

Segment 7 - Successful Discussions on Advance Care Planning and EOL

How can discussions on advance care planning and end-of-life care be successfully broached with patients and their family members?

November 3rd 2016

Segment 6 - Reimbursing Value-Based Oncology Care

Panelists discussed how patient-centered care can be valuated in the changing healthcare climate.

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