Oncology

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The investigators found that tumor mutational burden and PD-L1 expression, which have traditionally been used as indicators of immunotherapy efficacy, had little predictive value for survival in this cohort. | Image credit: Dragana Gordic - stock.adobe.com

Predictive Model Forecasts Advanced NSCLC Outcomes

By Jared Kaltwasser

August 14th 2025

The newly developed model has an area under the curve of 0.807 for predicting progression-free survival.

Dordaviprone is indicated for recurrent H3 K27M-mutant diffuse midline glioma, an ultra-rare, aggressive brain tumor primarily affecting children. | Image credit: wladimir1804 - stock.adobe.com

FDA Approves Dordaviprone as First and Only Treatment for Aggressive Form of Glioma

By Rose McNulty

August 6th 2025

Gen Li, PhD, MBA, president and founder of Phesi

Real-World Data, Digital Patient Profiles Are Revolutionizing Trial Design, Patient Recruitment: Gen Li, PhD, MBA

By Pearl Steinzor
Gen Li, PhD, MBA

August 4th 2025

Value-based care. | Image Credit: irissca - stock.adobe.com

Legal Navigation Services Key to Addressing Disparities in Cancer Care

By Cameron Santoro

July 31st 2025

Radiotherapy can work synergistically with immunotherapy by reprogramming the tumor microenvironment. | Image credit: Crystallight-stock.adobe.com

Brain Radiotherapy Plus ICIs Boost Survival in SCLC With Brain Metastases

By Jared Kaltwasser

July 30th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

Continuing Medical Education

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August 15th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology

August 15th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

October 28th 2016

Dr Scott Gottlieb: PCOC Is a Good Place to Meet Thought Leaders in Oncology

Patient-Centered Oncology Care offers attendees the opportunity to meet and interact with high-level people from various segments of the healthcare industry, explained Scott Gottlieb, MD, resident fellow at the American Enterprise Institute.

October 27th 2016

Age Is Not a Risk Factor for Post-Mastectomy Reconstructive Surgery

Surabhi Dangi-Garimella, PhD

Long-term follow-up of women who underwent mastectomy and breast reconstruction subsequent to a breast cancer diagnosis found that the success of the procedure and associated complications were not influenced by the woman’s age.

October 26th 2016

Will a Payer—Provider Collaboration Guarantee OCM Success?

Surabhi Dangi-Garimella, PhD

At the Payer Exchange Summit V, sponsored by the Community Oncology Alliance, oncologists and payers came together to discuss the role of collaboration and data sharing for the successful implementation of the Oncology Care Model.

October 26th 2016

Employers Express Their Concerns With Cancer Care at the COA Summit

Surabhi Dangi-Garimella, PhD

At the Payer Exchange Summit V, sponsored by the Community Oncology Alliance (COA), 2 employer groups and a provider participated on a panel to provide practical insight into the extraordinary challenges and decisions faced by employers and employees with a cancer diagnosis.

October 26th 2016

Dr Karen van Caulil on Value-Based Oncology Care Models for Large Employers

When transitioning towards value-based oncology, large employers should look to value-based models that have worked for other conditions, said Karen van Caulil, PhD, president and CEO of the Florida Health Care Coalition. These successful payment models include patient-centered medical homes, bundled payments, and accountable care organizations.

October 26th 2016

Barry Russo Discusses Challenges of Juggling OCM and MIPS

Many oncology practices are still trying to understand the new Oncology Care Model (OCM) structure and focus on data reporting as they simultaneously prepare to adapt to the Merit-based Incentive Payment System (MIPS), said Barry Russo, CEO of The Center for Cancer & Blood Disorders.

October 25th 2016

Pembrolizumab Is FDA-Approved as First-Line for PD-L1—Positive NSCLC

AJMC Staff

Patients newly diagnosed with non—small cell lung cancer (NSCLC) that expresses the programmed death ligand-1 (PD-L1) protein now have a new treatment option: pembrolizumab (Keytruda).

October 25th 2016

Strategies for OCM Implementation at the COA Payer Summit

Surabhi Dangi-Garimella, PhD

What are some of the challenges that clinical practices will face as they implement the Medicare Oncology Care Model (OCM)? What are some of the strategies that have worked for practices using similar payment models? These were some of the questions discussed at the Payer Exchange Summit V.

October 25th 2016

How Can Practices Seek Success With Oncology Payment Reform?

Surabhi Dangi-Garimella, PhD

At the Payer Exchange Summit V, sponsored by the Community Oncology Alliance, held October 24-25, 2016, in Tyson’s Corner, Virginia, Bruce Gould, MD, presented an overview of how cancer care has improved over the years, what the challenges are, and how practices can adapt to payment reform.

October 25th 2016

Dr Marianne Fazen on Why Cancer Is a Major Concern for Employers

Employers face tough decisions about rising costs, high-quality care, coordination of benefits, and workplace accommodations when employees are diagnosed with cancer, but they will always want to support those employees as best they can, according to Marianne Fazen, PhD, president and CEO of the Texas Business Group on Health.

October 25th 2016

Dr Kashyap Patel Discusses Challenges of OCM Implementation

Adopting the Oncology Care Model (OCM) is a challenging task for oncology practices that have to redesign their practices, but the shift from volume-based to value-based care is the way of the future, said Kashyap Patel, MD, of the Carolina Blood & Cancer Center.

October 24th 2016

Prior Authorization Pilot Reduced Health Plan's Cancer Drug Costs by 20%

Surabhi Dangi-Garimella, PhD

Including a real-time decision support tool in the prior authorization process significantly reduced the cost of therapy for UnitedHealthcare, while complying with nationally accepted guidelines established by the National Comprehensive Cancer Network.

October 24th 2016

Geographical Disparities Exist With US Smoking Prevention Policies

Surabhi Dangi-Garimella, PhD

Analysis by researchers from the American Cancer Society has found that US southern states rank at the top when it comes to death from cigarette smoking.

October 21st 2016

This Week in Managed Care: October 21, 2016

October 21st 2016

5 Approaches for Improved Collaboration in Oncology Care

Surabhi Dangi-Garimella, PhD

Communication gaps complicate healthcare and can devastate the prognosis of a patient undergoing cancer treatment. Here are a few ways to overcome inconsistencies with cancer care delivery

October 20th 2016

Obesity: A Growing Burden for Cancer Survivors

Priyam Vora

Patients with a history of cancer were more likely to suffer from obesity than the general population, according to new research studying the incidence of obesity in cancer survivors.

October 20th 2016

NCHS Report: Rising Survivorship in Pediatric Cancers, Brain Cancer Leading Cause of Death

Surabhi Dangi-Garimella, PhD

Brain cancer has replaced leukemia as the leading cause of cancer-related death in children and adolescents diagnosed with cancer.

October 20th 2016

Underutilization of Follow-up Imaging in Breast Cancer Survivors a Cause for Concern

Surabhi Dangi-Garimella, PhD

A study presented at the 2016 Annual Clinical Congress of the American College of Surgeons claims that one-third of women diagnosed with breast cancer do not receive their follow-up exam.

October 19th 2016

Study Recommends Nutritional Intervention for Survivors of Childhood Cancer

Surabhi Dangi-Garimella, PhD

Diets lacking essential nutrients can exacerbate chronic conditions in survivors of childhood cancer and dietary interventions might be necessary to reduce morbidities in this population.

October 19th 2016

Bach, Califf Elected to National Academy of Medicine

Mary Caffrey

Seventy Americans and 9 international members were elected to the National Academy of Medicine this week.

October 19th 2016

First PD-L1 Inhibitor Approved as Second-Line Treatment for NSCLC

Surabhi Dangi-Garimella, PhD

Atezolizumab, an inhibitor of the programmed death ligand-1 protein, has been approved for the treatment of patients with non-small cell lung cancer who failed to respond to treatment with platinum-based chemotherapy.

October 18th 2016

Minding the Gaps and Filling the Chasms in Oncology

Joseph Alvarnas, MD

As we enter a time of extraordinary advances in cancer care, some of the optimism over these advances has been temÂpered by the growing realization of the challenges of delivering these cancer care solutions.

October 17th 2016

Vice President Biden Delivers Cancer Moonshot Report to the Nation

Surabhi Dangi-Garimella, PhD

Vice President Joe Biden today presented the Cancer Moonshot report to President Barack Obama and the nation, delineating an actionable plan to transform cancer research and care delivery.

October 17th 2016

Enhancing Healthcare Delivery Research at the National Cancer Institute

Ann M. Geiger, MPH, PhD Ashley W. Smith, PhD, MPH Sarah C. Kobrin, PhD, MPH Stephen H. Taplin, MD

The National Cancer Institute's Division of Cancer Control and Population Sciences created the Healthcare Delivery Research Program in January 2015, recognizing the need for empirical evidence to address cancer care challenges.

October 14th 2016

Breast Cancer Death Rates Drop, but Racial Disparities Linger

Christina Mattina

Data released by the CDC today indicate that while breast cancer deaths are on the decline, black women still have worse outcomes than white women. The report also noted disparate trends in breast cancer incidence among different races and age groups.

October 14th 2016

This Week in Managed Care: October 14, 2016

This week, the top stories in managed care included HHS releasing the final rule for the Medicare Access and CHIP Reauthorization Act, a commentary on the downside of drug coupons, and the World Health Organization called on countries to enact a soda tax.

October 12th 2016

Radiomics to Predict Response to Antiangiogenic Therapy in Glioblastoma

Surabhi Dangi-Garimella, PhD

Radiomic combines imaging and computational technologies and can identify patients with recurrent glioblastoma who may benefit from using angiogenesis inhibitors.

October 12th 2016

Compassionate Use: FDA Is on Board, but Are Drug Manufacturers?

Surabhi Dangi-Garimella, PhD

A survey by Avalere Health found that only 19% of drug makers publicly post policies about their compassionate use programs.

October 12th 2016

What We're Reading: Limiting Use of Fentanyl, the Drug Fueling the Opioid Epidemic

AJMC Staff

What we're reading, October 12, 2016: a US senator calls for a limit to prescription fentanyl; healthcare costs aren't skyrocketing, despite claims; IBM's Watson will identify cancer treatment and clinical trials for IBM employees.

October 11th 2016

Reducing the Cost of Breast Cancer Treatment by $1 Billion

Surabhi Dangi-Garimella, PhD

A retrospective study in breast cancer patients suggests that patients can lower their out-of-pocket costs by speaking with their oncologist about alternate treatments that may be equally effective and understanding the drug coverage policy of their insurance plan.

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