Oncology

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The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.

The study identified several molecular markers related to SCLC prognosis by integrating somatic mutation profiles, mRNA transcriptome data, and clinical information. | Image credit: vitstudio - stock.adobe.com

Novel Biomarkers May Inform Prognosis in SCLC

By AJMC Contributor

June 6th 2025

Structured exercise programs should be a part of the standard of care for colon cancer following adjuvant chemotherapy, authors of the COMMANDS study recommended. | Image credit: Drazen - stock.adobe.com

Structured Exercise Program Improves Outcomes, Quality of Life in Colon Cancer

By Rose McNulty

June 6th 2025

young adult cancer | Image credit: Roswell Park Cancer Center

ASCO Sessions Explore Data and Dynamics of Early-Onset Cancer

By Mary Caffrey

June 6th 2025

FDA headquarters | Image Credit: - Tada Images- stock.adobe.com

5 Key FDA Approval Dates Mark a Milestone-Filled May

By Brooke McCormick

June 6th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

More News

December 13th 2018

Multidisciplinary Approach to Managing Oral Oncolytics

December 13th 2018

The Advent of Oral Oncolytics and Patient Access

December 12th 2018

From the Editor-in-Chief: Why the Future Never Arrives

Joseph Alvarnas, MD

December 12th 2018

Biosimilars Updates

Kelly Davio Samantha DiGrande

December 12th 2018

Medical World News: Regulatory Updates

December 12th 2018

Medical World News: Clinical Updates

December 11th 2018

Medical World News: Managed Care Updates, December 11, 2018

Mary Caffrey Allison Inserro Laura Joszt, MA David Bai, PharmD Samantha DiGrande

December 11th 2018

Cost Variation and Savings Opportunities in the Oncology Care Model

James Baumgardner, PhD Ahva Shahabi, PhD Christopher Zacker, RPh, PhD Darius Lakdawalla, PhD

Geographic variation in cancer treatment spending reveals that chemotherapy and hospital inpatient care may offer opportunities for savings for practices participating in the Oncology Care Model.

December 11th 2018

Getting the Patient's Viewpoint in the Oncology Quality Equation

Mary Caffrey

A recap of the discussion at the Philadelphia meeting of the Institute for Value-Based Medicine®, an initiative of The American Journal of Managed Care®.

December 11th 2018

OneOncology to Add Former US Senate Majority Leader Senator Bill Frist to Board of Directors

Former Tennessee US senator, heart and lung transplant surgeon, and healthcare entrepreneur brings dynamic expertise to the OneOncology national network.

December 10th 2018

Data and Collaboration Are Key for Value-Based Care Success

Laura Joszt, MA

Recap of the November 7 meeting of The American Journal of Managed Care®’s The Institute for Value-Based Medicine®. The dinner discussion, “Advancing Quality in Oncology Care” was held in Seattle, Washington.

December 10th 2018

McAneny Discusses OCM, Community Practices, and Building the Right Rewards

Surabhi Dangi-Garimella, PhD

The American Journal of Managed Care® sat down with Barbara McAneny, MD, president of the American Medical Association (AMA), to discuss how the AMA is working to "help create the healthcare system of the future."

December 10th 2018

Cancer Today and Cancer Tomorrow: Analysis of US Cancer Claims, 2007-2017

In this article, we use data from our FAIR Health database of over 27 billion privately billed healthcare claims to identify the cancer diagnosis categories with the highest percentage of claim lines among all cancer diagnosis categories.

December 8th 2018

Dr Lawrence Shulman Discusses Pathways and Improvements in Breast Cancer Treatment

Improvements in treatments have led to less toxicities and better quality of life for patients with breast cancer, said Lawrence N. Shulman, MD, director of the Center for Global Cancer Medicine at the Abramson Cancer Center, and professor of Medicine at the Hospital of the University of Pennsylvania.

December 7th 2018

The Future of Cancer Care

Joseph Alvarnas, MD

Joseph Alvarnas, MD, discusses the history of cancer care and what the future might look like in the space.

December 7th 2018

Renting Health vs Buying Cures: How New Financing Tools Can Boost Cancer Therapy Development

Andrew Smith

Evidence-Based OncologyTM sat down with Andrew W. Lo, PhD, to discuss his proposals to increase investment in medical innovation and utilization by giving investors more ways to support both research organizations and individual patients.

December 7th 2018

Increasing Rates of Cancer Screening

John B. Kisiel, MD

John B. Kisiel, MD, and Philip Parks, MD, MPH, provide an update on the future of cancer screenings and explain how improved treatment regimens offer the potential to reduce the cancer-related healthcare cost burden.

December 7th 2018

Beth Wittmer on Keeping Patients With Neutropenia Out of the Emergency Department

Informing patients about what to look for with neutropenia can help keep them out of the emergency department (ED) so they can be treated in the clinic, instead, said Beth Wittmer, RN, OCN, manager of care management at Florida Cancer Specialists and Research Institute.

December 6th 2018

Dr Sibel Blau Outlines Changes to Her Practice to Prepare for OCM

Years before the Oncology Care Model (OCM) was implemented, Northwest Medical Specialties started preparing by making changes to the personnel in the practice, explained Sibel Blau, MD, medical oncologist at Northwest Medical Specialties, PLLC.

December 4th 2018

Dr Thorvardur Halfdanarson Discusses Lack of Risk Factors, Biomarkers in NETs

There is a lot of disagreement, even within the neuroendocrine tumor (NET) circles, that there are biomarkers that predict outcomes and some that may even predict responses to therapy, explained Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic.

November 30th 2018

CDC Data: Life Expectancy Decreases as Deaths From Suicide, Drug Overdose Increase

Laura Joszt, MA

New reports from the CDC have highlighted troubling increasing trends in suicides and drug overdose rates as life expectancy in the United States declined.

November 28th 2018

Cancer Therapy's Impact on Cognitive Function May Be Due to Accelerated Aging

Kelly Davio

A study published this week suggests that some anticancer treatments speed up the biological aging process, and this aging effect could be linked to the cognitive decline experienced by patients undergoing cancer treatment.

November 24th 2018

Podcast: This Week in Managed Care—Addressing Social Needs Impacting Health and Other Health News

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

November 23rd 2018

This Week in Managed Care: November 23, 2018

This week, the top managed care news included HHS Secretary Alex Azar hinting that the government may get more involved in addressing social needs impacting health; work rules in Arkansas cost thousands their Medicaid coverage; research finds a shorter course of hepatitis C treatment may be just as effective as the full course of treatment.

November 22nd 2018

Beth Wittmer on Educating Patients on Neutropenia as a Side of Effect of Cancer Treatment

As patients start chemotherapy to treat their cancer, they are educated on the side effects, particularly neutropenia, said Beth Wittmer, RN, OCN, manager of care management at Florida Cancer Specialists and Research Institute.

November 20th 2018

Dr Thorvardur Halfdanarson: Access Is a Big Management Challenge in NETs

Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic, outlines the biggest management challenges in neuroendocrine tumors (NETs).

November 17th 2018

AMA's McAneny Calls for Real-time Oncology Payment Model Led by Physicians

Mary Caffrey

In the keynote address at Patient-Centered Oncology Care® 2018, Barbara McAneny, MD, a New Mexico oncologist/hematologist and the current president of the American Medical Association (AMA), shared her diagnosis for the current crisis in US healthcare, as well as a prescription—a new real-time oncology payment model led by physicians.

November 17th 2018

Dr Brian Koffman Highlights the Benefits and Risks of CAR T Therapy

Since chimeric antigen receptor (CAR) T-cell therapy is still in early development there are benefits and risks that eligible patients will have to weigh, including the durable response against the limited amount of data and toxic side effects, said Brian Koffman, MDCM, DCFP, DABFM, MS Ed, medical director, CLL Society.

November 17th 2018

FDA Gives Speedy Approval to Brentuximab for Peripheral T-Cell Lymphoma

Allison Inserro

The FDA announced Friday it expanded the approved use of brentuximab vedotin (Adcetris) in combination with chemotherapy for adult patients with certain types of peripheral T-cell lymphoma, using a new review process designed to increase efficiency.

November 16th 2018

Nivolumab Plus Azacitidine Increased Response Rates in Patients With Relapsed AML

David Bai, PharmD

The addition of nivolumab to azacitidine led to significantly better overall response rate and overall survival compared with previous hypomethylating agent-based regimens in patients with relapsed acute myeloid leukemia (AML), according to the results of a recent phase 2 study.

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