Oncology

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Most of the patients who experienced superior outcomes with atezolizumab and chemotherapy had higher levels of NOTCH1 expression. | Image credit: Pixel-Shot - stock.adobe.com
NOTCH1 Levels Impact Immune Response in SCLC

September 2nd 2025

Patients with small cell lung cancer (SCLC) experienced better responses to immune checkpoint inhibitors if they had higher levels of NOTCH1 expression in a recent study.

The findings can help guide ongoing and future clinical trials to help solve remaining challenges in LS-SCLC. | Image credit: Jennifer - stock.adobe
Neoadjuvant Immunotherapy Plus Chemotherapy Shows Promise in LS-SCLC

August 31st 2025

PD-1 blockade has previously shown success in a first-line setting in ES-SCLC, and nab-paclitaxel is albumin-bound and solvent-free, which the investigators explained may minimize the toxicity associated with paclitaxel therapy. | Image credit: didesign - stock.adobe.com
Camrelizumab Plus Carboplatin, Nab-Paclitaxel Shows Efficacy in ES-SCLC

August 29th 2025

For rent sign | Image Credit: David Gales - stock.adobe.com
Housing Assistance May Help Renters With Cancer Better Withstand Medical Financial Strain

August 28th 2025

Patient with cancer undergoing chemotherapy | Image credit: RFBSIP – stock.adobe.com
Many Patients With Advanced Cancer Report Care Misaligned With Their Goals

August 25th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations
Continuing Medical Education
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September 5th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
September 5th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

Prognosis and Risk Stratification of Myelofibrosis
December 28th 2018

Prognosis and Risk Stratification of Myelofibrosis

Diagnosis of Myelofibrosis
December 28th 2018

Diagnosis of Myelofibrosis

Overview of Myelofibrosis
December 28th 2018

Overview of Myelofibrosis

Chemotherapy for Solid Tumors Associated With Increased Risk of AML, MDS
December 28th 2018

Chemotherapy for Solid Tumors Associated With Increased Risk of AML, MDS

Laura Joszt, MA
Patients who are treated with chemotherapy for their solid tumors have an increased risk of therapy-related myelodysplastic syndrome and acute myeloid leukemia (tMDS/AML) despite advances in chemotherapy regimens, according to a new study in JAMA Oncology.
This Year in Managed Care: 2018 Recap
December 28th 2018

This Year in Managed Care: 2018 Recap

This week, we recapped the top news from 2018 with a look at policy changes, new research, decisions at the polls, and more.
Males With MPN Have More Aggressive Disease Biology, Independent of Other Factors
December 28th 2018

Males With MPN Have More Aggressive Disease Biology, Independent of Other Factors

Jackie Syrop
Males with myeloproliferative neoplasms have worse survival compared with females with MPN, even when adjusted for age at presentation, presenting phenotype, and molecular characteristics.
The Most-Read Articles From Evidence-Based OncologyTM for 2018
December 27th 2018

The Most-Read Articles From Evidence-Based OncologyTM for 2018

Mary Caffrey
From chimeric antigen receptor T-cell therapy to value-based contracting, reimbursement issues dominated reader interest.
Reimbursement With Treatment for Multiple Myeloma
December 27th 2018

Reimbursement With Treatment for Multiple Myeloma

Studies Presented at ASH 2018 and the Outlook for Myeloma
December 27th 2018

Studies Presented at ASH 2018 and the Outlook for Myeloma

MRD Testing and Relapsed/Refractory Multiple Myeloma Treatment Options
December 27th 2018

MRD Testing and Relapsed/Refractory Multiple Myeloma Treatment Options

Transplant Patients' Options, CoMMpass Study, and Doublet Versus Triplet Therapy
December 27th 2018

Transplant Patients' Options, CoMMpass Study, and Doublet Versus Triplet Therapy

Dr Robert Daly Discusses How Clinical Pathways Can Reduce Disparities in Breast Cancer
December 25th 2018

Dr Robert Daly Discusses How Clinical Pathways Can Reduce Disparities in Breast Cancer

There can be great disparities across the country and across races when it comes to cancer care, but clinical pathways can help standardize care so everyone gets the most efficacious treatments, said Robert Daly, MD, MBA, medical oncologist, Memorial Sloan Kettering Cancer Center.
Challenges and Opportunities in the Oncology Care Model
December 23rd 2018

Challenges and Opportunities in the Oncology Care Model

Laura Joszt, MA
The practices that have been participating in CMS’ Oncology Care Model have undergone significant practice transformation in order to be successful in the program. However, even after being in the model for 2 years, there are still remaining opportunities for investment.
Diabetes, Cancer Interviews Among Most-Watched Videos of 2018
December 20th 2018

Diabetes, Cancer Interviews Among Most-Watched Videos of 2018

Laura Joszt, MA
Throughout the year, The American Journal of Managed Care® (AJMC®) offered a number of video programs, including Peer Exchange discussions and interviews, on a range of topics. Here are the most-watched videos published by AJMC® in 2018.
Dr Barbara McAneny Explains the Current Focus of Care Management in Oncology
December 20th 2018

Dr Barbara McAneny Explains the Current Focus of Care Management in Oncology

Keeping people with cancer out of the hospital is a low-hanging fruit that is of huge benefit to patients, explained Barbara L. McAneny, MD, president of the American Medical Association.
Dr Michael Kolodziej Reflects on OCM and What Might Come After
December 19th 2018

Dr Michael Kolodziej Reflects on OCM and What Might Come After

The Oncology Care Model (OCM) is not a sustainable model, but while it finishes out the 5-year pilot, CMS will likely be fine-tuning bundled payments in medical oncology, said Michael Kolodziej, MD, vice president and chief innovation officer at ADVI Health, Inc.
Report Assesses Degree of Alignment Between ASCO, ESMO Oncology Frameworks
December 18th 2018

Report Assesses Degree of Alignment Between ASCO, ESMO Oncology Frameworks

Allison Inserro
A joint assessment comparing the results of value frameworks created by the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO) found that the frameworks produce comparable measures of the clinical benefits of new cancer therapies in roughly two-thirds of more than 100 drug comparisons examined.
Dr Sibel Blau Discusses Physician, Staff Education Around OCM
December 17th 2018

Dr Sibel Blau Discusses Physician, Staff Education Around OCM

Implementing the Oncology Care Model required educating physicians and staff on a new way to do the work and why the changes were necessary under the new model, explained Sibel Blau, MD, medical oncologist at Northwest Medical Specialties, PLLC.
Common Factors Among Successful Practices in the OCM
December 16th 2018

Common Factors Among Successful Practices in the OCM

Laura Joszt, MA
Practices participating in the Oncology Care Model have now received performance results for 2 periods, and many practices were surprised that they didn’t perform as well as expected. In general, some of the practices have found it difficult to predict success in the model, but there have been positive results from the OCM.
Dr Robert Daly Explains the Importance of Updating Pathways With New Data
December 16th 2018

Dr Robert Daly Explains the Importance of Updating Pathways With New Data

As new breakthrough therapies are approved, clinical pathways have to be kept updated in order for patients to get the best treatments, said Robert Daly, MD, MBA, medical oncologist, Memorial Sloan Kettering Cancer Center.
Podcast: This Week in Managed Care—US Uninsured Rate Increases and Other Health News
December 16th 2018

Podcast: This Week in Managed Care—US Uninsured Rate Increases and Other Health News

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.
Beth Wittmer Discusses Diet Restrictions With Neutropenia
December 15th 2018

Beth Wittmer Discusses Diet Restrictions With Neutropenia

Patients with neutropenia or at risk of it need to be cautious of their diet, said Beth Wittmer, RN, OCN, manager of care management at Florida Cancer Specialists and Research Institute.
Using Cost Variation to Identify Savings Opportunities Under the OCM
December 14th 2018

Using Cost Variation to Identify Savings Opportunities Under the OCM

A study published in this month's issue of The American Journal of Managed Care® estimated standardized episode-level spending for patients across subcategories of care for each hospital referral region—defined by the Dartmouth Atlas—in order to identify the greatest opportunities for cost savings under the Oncology Care Model (OCM).
This Week in Managed Care: December 14, 2018
December 14th 2018

This Week in Managed Care: December 14, 2018

This week, the top managed care news included a report that found uninsured rates were on the rise in 2017; an analysis of rising health insurance costs for families; predictions for cardiology trends in 2019.
Equity in Cancer Care: A Viewpoint From Patient Advocates
December 13th 2018

Equity in Cancer Care: A Viewpoint From Patient Advocates

Jaime Rosenberg
A panel of patient advocates at the National Comprehensive Cancer Network Patient Advocacy Meeting, held in Washington, DC, discussed the reasons behind and consequences of inequities in cancer care.
Adherence With CDK4/6 Inhibitors
December 13th 2018

Adherence With CDK4/6 Inhibitors

Patient Management of CDK4/6 Inhibitors
December 13th 2018

Patient Management of CDK4/6 Inhibitors

Dispensing of CDK4/6 Inhibitors
December 13th 2018

Dispensing of CDK4/6 Inhibitors

Multidisciplinary Approach: Managing CDK4/6 Inhibitors
December 13th 2018

Multidisciplinary Approach: Managing CDK4/6 Inhibitors

Patients' Perspectives on CDK4/6 Inhibitors
December 13th 2018

Patients' Perspectives on CDK4/6 Inhibitors

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