Oncology

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Emerging therapies, including immune checkpoint inhibitors and antibody-drug conjugates, could significantly impact SCLC treatment, authors of a recent review concluded. | Image credit: Vitalii Vodolazskyi - stock.adobe.com

Is a New Era of SCLC, LCNEC Treatments on the Horizon?

By AJMC Contributor

July 23rd 2025

Emerging therapies, including antibody-drug conjugates and biomarker-driven approaches, have the potential to significantly impact outcomes for patients with traditionally poor prognoses and limited options.

Christine Pfaff, MBA, RPh | Image: LinkedIn

COA Welcomes Christine Pfaff, MBA, RPh, to Leadership Team

July 22nd 2025

AJMC Q&A with Robert Kratzke | Background image credit: ipopba - stock.adobe.com

Making Reflexive Testing the Standard of Care in Lung Cancer: Robert Kratzke, MD

By Hayden E. Klein
Robert Kratzke, MD

July 22nd 2025

Cancer diagnosis financial strain | Image Credit: Maggie-sort.chatgpt.com

Cancer Diagnoses Bring Major Financial Burden for Privately Insured Adults

By Maggie L. Shaw

July 21st 2025

COVID-19 vaccine for patients with cancer. | Image Credit: Framestock - stock.adobe.com

COVID-19 Boosters Crucial for Patients With Cancer Despite Low Uptake

By Cameron Santoro

July 17th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

Continuing Medical Education

July 23rd 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology

July 23rd 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

This Week in Managed Care: February 10, 2017

February 10th 2017

This Week in Managed Care: February 10, 2017

This week, the top managed care stories included final enrollment numbers for the Affordable Care Act for 2017, a report that revealed low rates of lung cancer screening, and a study found that a population-based weight management strategies can prevent diabetes.

February 10th 2017

The Complex Relation Between Clinical Outcomes, Drug Approval, and Drug Price

Surabhi Dangi-Garimella, PhD

Does an FDA approval guarantee clinical benefit of a drug? How does it influence drug price?

February 9th 2017

Hopkins' Researchers Discover Carcinogenic Metals in E-Cigarette Liquid

Surabhi Dangi-Garimella, PhD

Analysis of the liquid used to make the aerosol in e-cigarettes has led to the discovery of high levels of 5 potentially toxic heavy metals.

February 8th 2017

Michigan Study Finds Obesity Lowers Hospice Use Among Seniors

Surabhi Dangi-Garimella, PhD

A long-term health study has found that seniors with a higher body mass index were less likely to make use of hospice care. Additionally, obese seniors spent significantly fewer days in hospice care than their nonobese counterparts.

February 8th 2017

Breast Cancer Patients Not Getting Desired Genetic Testing, Counseling

Christina Mattina

A recent JAMA study found that women with breast cancer would generally like to receive genetic testing and counseling, but less than one-third actually receive it.

February 7th 2017

PMC Report Proposes Strategies for Clinical Integration of Personalized Medicine

Surabhi Dangi-Garimella, PhD

The Health Care Working Group of the Personalized Medicine Coalition (PMC) has published a new report that provides a framework for the successful integration of personalized medicine in the clinic.

February 7th 2017

Low-Income Women Less Likely to Keep Jobs After Breast Cancer Treatment

Christina Mattina

Women with breast cancer are twice as likely to return to work after treatment if their employer makes accommodations for them, but workplace accommodation and job retention are significantly lower for low-income and minority women.

February 6th 2017

ACS Study Voices Concerns Over Low US Lung Cancer Screening Rates

Surabhi Dangi-Garimella, PhD

Lung cancer screening rates in the United States remained low and unchanged in 2015 despite recommendations that high-risk current and former smokers be screened.

David Fabrizio Explores Complexities of Surrogate Endpoints in Cancer Clinical Trials

February 6th 2017

David Fabrizio Explores Complexities of Surrogate Endpoints in Cancer Clinical Trials

The FDA has been willing to explore the utilization of surrogate endpoints like tumor response in clinical trials, but it is unclear whether these endpoints correlate with overall survival, said David Fabrizio of Foundation Medicine, Inc. However, he emphasized that overall survival does not necessarily benefit the patient if the additional days gained are not quality days.

Dr Stuart Goldberg Discusses How COTA Analyzes Oncology Data

February 6th 2017

Dr Stuart Goldberg Discusses How COTA Analyzes Oncology Data

Cancer Outcomes Tracking and Analytics (COTA) focuses on stratifying cancer patients by their many subtypes to understand the different treatments, outcomes, and costs for each, according to Stuart Goldberg, MD, chief medical officer, COTA, John Theurer Cancer Center.

February 2nd 2017

Report Commissioned by COA Explores "Murky" World of Pharmacy DIR Fees

Christina Mattina

A white paper commissioned by the Community Oncology Alliance (COA) delved into the practice of “direct and indirect remuneration” fees administered by pharmacy benefit managers and how they could drive up drug prices for Medicare Part D beneficiaries and taxpayers.

February 1st 2017

Pembrolizumab Now Approved for First-Line Treatment of Lung Cancer in Europe and the US

Pembrolizumab (Keytruda) has received green light from the European Commission for the first-line treatment of a select population of adult patients with metastatic non-small cell lung cancer.

February 1st 2017

A Focus on Lifestyle and Appropriate Screening During National Cancer Prevention Month

Surabhi Dangi-Garimella, PhD

During the National Cancer Prevention Month, there will be renewed fervor among healthcare providers to ensure individuals pay greater attention toward preventive measures against cancer.

Dr David L. Porter Explains Variations in CAR-T Cell Trial Criteria

February 1st 2017

Dr David L. Porter Explains Variations in CAR-T Cell Trial Criteria

The criteria to enroll cancer patients in a clinical trial of CAR-T cells vary according to their disease, past therapy, and how far along they are in different treatments, said David L. Porter, MD, of the University of Pennsylvania Health System.

January 31st 2017

Study Recommends Measures to Fill Quality Gaps in Oncology Care

Surabhi Dangi-Garimella, PhD

A multicollaborative study has identified gaps in existing quality measures used by accountable care programs that could result in missed opportunities to improve patient outcomes.

Kim Eason on the Benefits of Patient-Centered Medical Homes

January 31st 2017

Kim Eason on the Benefits of Patient-Centered Medical Homes

Patient-centered medical homes are valuable because they allow insurers to look at the cost of all of the patient’s treatments, services, and physicians throughout the continuum of care, explained Kim Eason, manager at Horizon Blue Cross Blue Shield of NJ.

January 30th 2017

Leaders of Cardiologists, Oncologists Decry Travel Ban

The American College of Cardiology is set to hold its annual meeting in the nation's capital March 17-20, 2017.

January 30th 2017

Need for Switch to Incretins in T2D an Indicator of Pancreatic Cancer

Surabhi Dangi-Garimella, PhD

A retrospective analysis of evidence from prescription data gathered in Belgium and Italy has found that uncontrolled diabetes might be an early sign of pancreatic cancer.

January 29th 2017

Healthy People 2020 Targets Achieved in 30 States for Colorectal Cancer, 28 for Cervical Cancer

Surabhi Dangi-Garimella, PhD

A review of 2013 cancer statistics in the United States by the CDC showed that 67% of people survived at least 5 years after their cancer diagnosis.

Dr Joseph Alvarnas: Innovative Therapies Can Change Oncology Care Paradigm

January 29th 2017

Dr Joseph Alvarnas: Innovative Therapies Can Change Oncology Care Paradigm

Technological advances in cancer care have changed the very process of treatment, as now oncologists can gain more insight into the most effective therapy for each individual patient, according to Joseph Alvarnas, MD, of the City of Hope and editor-in-chief of Evidence-Based Oncology.

This Week in Managed Care: January 27, 2017

January 27th 2017

This Week in Managed Care: January 27, 2017

This week, the top managed care stories included Aetna and Humana's merger getting blocked, the first Affordable Care Act replacement proposal was unveiled, and an analysis of regional cancer death trends.

January 27th 2017

NICE Endorses Funding for Ibrutinib in Patients With CLL

Patients who have had at least 1 prior therapy or carry a 17p deletion or TP53 mutation are now eligible to be treated with ibrutinib (Imbruvica) in the United Kingdom.

Dr Carrie Stricker on Why Clinician Voices Are Needed in Health IT Development

January 27th 2017

Dr Carrie Stricker on Why Clinician Voices Are Needed in Health IT Development

The most transformative software companies are those that have seized the opportunity to incorporate clinician and patient voices into the design of their health IT tools, according to Carrie Stricker, PhD, RN, AOCN, chief clinical officer and co-founder of Carevive.

January 27th 2017

Coverage of 2016 American Society of Hematology Meeting Available From AJMC®

The American Journal of Managed CareÂ® presents its annual special issue of Evidence-Based Oncologyâ„¢ featuring full coverage of the 58th annual meeting of the American Society of Hematology. CAR T-cell treatments gained notice, as did sessions on patients’ improving quality of life and addressing the high costs of new therapies.

January 26th 2017

First Trial With Universal CAR-T Treatment in Pediatric Leukemia Reports Success

Surabhi Dangi-Garimella, PhD

“Off-the-shelf” chimeric antigen receptor (CAR)-T cells, also known as universal donor cells, were used in 2 young infants with relapsed, refractory acute lymphoblastic leukemia resulted in molecular remission in 28 days in both infants.

January 26th 2017

New Target for Treating Glioblastoma May Increase Survival Time

Researchers from the Peter O’Donnell Jr. Brain Institute and Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern may have found the ultimate drivers of glioblastoma cell proliferation.

January 25th 2017

Study Doubts Impact of Pre-ACA Medicaid Expansion on Access to Cancer Surgery

Surabhi Dangi-Garimella, PhD

Expansion of Medicaid coverage prior to the authorization of the Affordable Care Act (ACA) in 2010 reduced the uninsured rate in New York State, but did not improve access to cancer surgery.

January 25th 2017

Innovative Approach to Precision Trial Design: NCI-MATCH and Beat AML

Surabhi Dangi-Garimella, PhD

At the 58th annual meeting of the 58th American Society of Hematology, representatives from 2 national clinical trials, Beat AML and NCI-MATCH, detailed how they were incorporating genomic profiling to assign patients to different treatment arms.

January 25th 2017

JAMA Study Discovers Regional Trends in Cancer-Related Mortality

Surabhi Dangi-Garimella, PhD

An analysis of cancer death records across the country, by researchers at the University of Washington, has identified clusters of counties that had a particularly high rate of mortality depending on the cancer type.

Pam Mangat Discusses ASCO's Plans to Address Challenges of TAPUR Trial

January 25th 2017

Pam Mangat Discusses ASCO's Plans to Address Challenges of TAPUR Trial

Researchers implementing the TAPUR trial have encountered some difficulties, particularly in filling the study cohorts, said Pam Mangat, MS, associate director TAPUR study at the American Society of Clinical Oncology (ASCO). However, the ASCO team is dedicated to forging ahead and addressing those challenges.

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