Oncology

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Offline data augmentation can significantly enhance deep learning techniques, improving classification performance compared to models trained solely on original clinician skin images. | Image Credit: Alexander - stock.adobe.com

Optimized Deep Learning Model Classifies Smartphone Images of Malignant Skin Lesions

By AJMC Contributor

May 12th 2025

Across various classes, the researchers identified a model that, when coupled with appropriate data augmentation and optimization partner, may help aid in the detection of skin cancer.

With inconclusive treatment guidance and varying findings from clinical trials, the prognosis of transformed SCLC remains poor. | Image credit: Crystal Light - stock.adobe.com

Whole Exome Sequencing Identifies Distinct Profile of Transformed SCLC

By AJMC Contributor

May 12th 2025

The report suggests a TBS cutoff value of 3 will serve as a meaningful prognostic tool in HCC, but differences in patient populations and imaging techniques may affect the value of that cutoff, the authors noted. | Image credit: Jo Panuwat D - stock.adobe.com

HCC Tumor Burden Score Predicts Long-Term Outcomes Following MWA

By Jared Kaltwasser

May 7th 2025

Doctor showing lung x ray | Image credit: didesign – stock.adobe.com

Tarlatamab Safety Varies Between Clinical and Real-World SCLC Trials

By Hayden E. Klein

May 6th 2025

CureCancer | Image Credit: © MMPhoto21-sotck.adobe.com

COA 2025: Insight, Innovation, and Independent Strength

By Maggie L. Shaw

May 5th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

More News

December 8th 2014

Evaluating Safety, Efficacy, and Outcomes of TKIs in CML

A poster session on the second day of the 56th annual meeting of the American Society of Hematology, held December 6-9, San Francisco, was dedicated to trials evaluating therapeutic options in chronic myelogenous leukemia. Data presented included safety, efficacy, managing comorbidities, and biological differences that drive response to therapy.

December 8th 2014

Jan Geissler Explains Differing Perceptions for Living With CML

Perceptions of chronic myelogenous leukemia (CML) and how to live with it are very different for patients and physicians, and a strong dialogue is needed to overcome the disparity, according to Jan Geissler, co-founder of the CML Advocates Network.

December 8th 2014

Dr Giuseppe Saglio Compares Efficacy, Safety of Nilotinib With Imatinib for CML Patients

Although nilotinib as a first-line therapy for chronic myelogenous leukemia is a more effective treatment than imatinib, nilotinib's side effects are too much for patients.

December 8th 2014

TKIs and Molecular Response in CML: the EURO-SKI Study

On the second day at the Annual Meeting of the American Society of Hematology 2014, Francois-Xavier Mahon, MD, PhD, Bordeaux Hospital, INSERM 1035, Bordeaux, France, shared the results from the European LeukemiaNet Stop TKI (EURO-SKI) study; the trial used tyrosine kinase inhibitors (TKIs) in CML to define prognostic markers to increase the rate of patients in durable deep molecular response after stopping TKI.

Best of ASH Presentations: Platelets, Lenalidomide for MDS, and Sorefenib in AML

December 8th 2014

Best of ASH Presentations: Platelets, Lenalidomide for MDS, and Sorefenib in AML

The plenary session on the second day of the 56th Annual Meeting of the American Society of Hematology, held December 6-9 in San Francisco, saw the best presentations, selected by the Program Committee, from among the thousands of scientific abstracts that were accepted for the meeting. These talks included a JAK/STAT-mediated thrombopoietin regulation by the Ashwell-Morell receptor, lenalidomide-mediated casein kinase regulation in myelodysplastic syndrome, and the results of the SORAML trial in acute myeloid leukemia.

December 7th 2014

Greg Stephens Offers Advice for the Newly Diagnosed CML Patient

One of the reoccurring themes at the 56th Annual Meeting of the American Society of Hematology was the importance of proper monitoring, said Greg Stephens, executive director of the National CML Society.

December 7th 2014

Dr Elaine Fuchs Explains How Stem Cell Discoveries Fuel Cancer Therapeutics

Isolating and comparing cancer stem cells with their normal counterparts has allowed researchers to identify hundreds of differences that can be used to target therapies, said Elaine Fuchs, PhD, an investigator at the Howard Hughes Medical Institute at the Rockefeller University.

Healthcare Costs in Need of Solutions: Experts at ASH Agree

December 7th 2014

Healthcare Costs in Need of Solutions: Experts at ASH Agree

While medical oncologists, drug developers, and research scientists presented their research findings and novel treatment options in hematological cancers, a special session in the afternoon on the first day of the 56th Annual Meeting of the American Society of Hematology (ASH), held December 6 to 9 in San Francisco, addressed the aspect of cost of care and the increasing financial burden faced by the cancer patient.

Dr Mark G. Kris on Use of the Patient's Genome

December 5th 2014

Dr Mark G. Kris on Use of the Patient's Genome

Recent important changes in oncology have led to major advances that allow providers to recommend very specific therapies, said Mark G. Kris, MD, William and Joy Ruane chair in thoracic oncology at Memorial Sloan Kettering Cancer Center.

December 5th 2014

Markers for Mental Health Problems in Cancer Patients Identified

December 5th 2014

Rapid Progress in Bench-to-Clinic Reported for Several Cancers

The results were presented at the recent Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, a meeting jointly sponsored by the NCI, AACR, and EORTC.

December 4th 2014

340B: A Double-Edged Sword

While ASCO is calling to update the 340B drug discount program, hospitals that serve economically diverse populations make a case for the program: "Because of 340B, we don't have to turn patients away when they can't pay."

December 4th 2014

ASH Adds to the "Choosing Wisely" List

The American Society of Hematology has added 5 more recommendations to it's Choosing Wisely list, which was published in the journal Blood,

December 4th 2014

Xalkori Shows Significant Benefit As First-Line in ALK-Positive NSCLC

The study, published in NEJM, found that PFS improved by nearly 4 months while ORR improved by nearly 30%.

December 4th 2014

Prostate Cancer Diagnostic Test Could Prevent Over or Under Treatment

By distinguishing low- and intermediate-risk patients, Oncotype DX is predicted to avoid over- and under-treatment of prostate cancer patients.

December 3rd 2014

Amgen's Blincyto Approved for B-Cell ALL

Blincyto, which was considered a promising immunotherapy with a novel mechanism of action, was approved 5 months prior to its PDUFA date.

December 3rd 2014

Gene Could Be a New Biomarker For Diagnosis of TNBC

Absence of a microRNA in TNBC resulted in the overexpression of RASAL2 in those tumors. Patients overexpressing RASAL2 had poorer survival, research showed.

December 3rd 2014

Most People Dismiss Early Signs of Cancer: PLOS ONE Study

People could be putting their lives at risk by dismissing potential warning signs of cancer as less serious symptoms, according to a Cancer Research UK-funded study published in PLOS ONE. The survey found that nearly 97% of people with symptoms failed to act on them.

December 2nd 2014

Bisphosphonates Can Prevent Certain Cancers: PNAS Study

A study found new indications for a drug that is widely used in the treatment of osteoarthritis, based on an observation that those on the medication had a lower incidence of several cancers.

December 2nd 2014

Astra Files NDA for Iressa as First-Line in NSCLC

Iressa, an EGFR inhibitor, is widely used in the treatment of advanced, metastatic NSCLC.

December 1st 2014

Cabozantinib Fails to Meet Primary End-Point in mCRPC

Failure of the drug in the phase 3 COMET-2 study was anticipated following the reported failure of the earlier COMET-1 trial.

November 30th 2014

AJMC Stakeholder Summit Explores Challenges in Using Data to Make Decisions in Oncology

What makes a cancer therapy effective may be in the eye of the stakeholder, even though everyone involved in healthcare decisions relies on evidence-based information. Evidence-Based Oncology, a publication of The American Journal of Managed Care, this month publishes a condensed version of the discussion among payers on how to improve collection and use of collection of data to make better evidence-based decisions in oncology.

November 30th 2014

Genes Could Predict

The NIH-funded study, published in the New England Journal of Medicine, identified mutations that are harbored early and could be potential early-onset biomarkers for detection.

November 29th 2014

A 2-Drug Combination Successfully Thwarts Colorectal Cancer

A study by the University of Colorado Cancer Center published in the journal PLoS ONE and concurrent phase I clinical trial is examining a new strategy: targeting both important cancer-causing pathways simultaneously.

November 28th 2014

Specialty Drugs a Rising Healthcare Cost

Surabhi Dangi-Garimella, PhD

Early this week, Novation, a healthcare services company that oversees supply chain management, called on Genentech to reverse its decision to use only specialty drug distributors instead of wholesale distributors for its widely used anticancer treatments, Avastin, Rituxan, and Herceptin.

November 28th 2014

International Variation in Drug Usage

A new RAND study explores the range of possible causes that might explain observed international variations in the usage of medicines for selected disease areas: dementia, osteoporosis, cancer, diabetes, and hepatitis C.

Dr Peter P. Yu Describes the Many Dimensions to Providing Quality Cancer Care

November 28th 2014

Dr Peter P. Yu Describes the Many Dimensions to Providing Quality Cancer Care

There are many dimensions to providing quality cancer care, but they're always tied to aligning the best outcomes with the patient's preferences, Peter P. Yu, MD, FASCO, 2014-2015 president of ASCO, said at the Patient-Centered Oncology Care meeting.

November 26th 2014

Yale Study Shows PD-L1 Expression Can Predict Response to PD-L1 Inhibitors

The trial, conducted across various tumor types, monitored PD-L1 expression in biopsy samples before and during treatment with the PD-L1 inhibitor MPDL3280A being developed by Genentech.

November 26th 2014

Pre-Op Work Can Prevent Risks Associated With Morcellation: Study Finds

Following on the heels of the FDA's advice on the risk of using morcellators for treating fibroids, researchers in France have released results of a study that delineates a method that can avoid the risk of morcellating a pre-existing uterine sarcoma.

November 26th 2014

How Medicaid Reimbursements Impact Cancer Screening Rates

Laura Joszt, MA

Physicians who receive higher reimbursements for routine office visits are more likely to perform cancer screening tests on Medicaid beneficiaries, according to a new study in Cancer.

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