Oncology

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The investigators found that tumor mutational burden and PD-L1 expression, which have traditionally been used as indicators of immunotherapy efficacy, had little predictive value for survival in this cohort. | Image credit: Dragana Gordic - stock.adobe.com
Predictive Model Forecasts Advanced NSCLC Outcomes

August 14th 2025

The newly developed model has an area under the curve of 0.807 for predicting progression-free survival.

Dordaviprone is indicated for recurrent H3 K27M-mutant diffuse midline glioma, an ultra-rare, aggressive brain tumor primarily affecting children. | Image credit: wladimir1804 - stock.adobe.com
FDA Approves Dordaviprone as First and Only Treatment for Aggressive Form of Glioma

August 6th 2025

Gen Li, PhD, MBA, president and founder of Phesi
Real-World Data, Digital Patient Profiles Are Revolutionizing Trial Design, Patient Recruitment: Gen Li, PhD, MBA

August 4th 2025

Value-based care. | Image Credit: irissca - stock.adobe.com
Legal Navigation Services Key to Addressing Disparities in Cancer Care

July 31st 2025

Radiotherapy can work synergistically with immunotherapy by reprogramming the tumor microenvironment. | Image credit: Crystallight-stock.adobe.com
Brain Radiotherapy Plus ICIs Boost Survival in SCLC With Brain Metastases

July 30th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations
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August 16th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
August 16th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

Sabarish Ayyappan, MD
February 20th 2025

Geographic Barriers Impede Access to Novel Cancer Treatments

Kyle Munz Sabarish Ayyappan, MD
In the wake of novel bispecific and chimeric antigen receptor T-cell therapies for various cancers, geography still plays a big role in patients' abilities to receive such treatments.
Fueling Cancer Research Breakthroughs With Patient Contributions
February 20th 2025

Fueling Cancer Research Breakthroughs With Patient Contributions

Maggie L. Shaw Karen Winkfield, MD, PhD
In part 3 of this conversation, Karen Winkfield, MD, PhD, executive director of the Meharry-Vanderbilt Alliance, discusses why basic scientific research remains essential and how patient experiences contribute.
Patient talking with doctor | Image credit: Monkey Business - stock.adobe.com
February 20th 2025

Cancer Mortality Rates Still High Among Black Patients, Despite Overall Decline

Julia Bonavitacola
Black individuals had a 2-fold risk of cancer death related to prostate, myeloma, and stomach cancers compared with White individuals.
Vivek Murthy, MD | Image credit: NBC News
February 19th 2025

Alcohol and Cancer Risk: Murthy’s Parting Call for Warning Labels

Maggie L. Shaw
radiology x-ray lung cancer | Image credit: utah51 – stock.adobe.com
February 17th 2025

2 Immunotherapies Show Comparable Benefits in Extensive-Stage Small Cell Lung Cancer

Hayden E. Klein
When added to chemotherapy, researchers found no significant difference in overall or progression-free survival between PD-1 and PD-L1 inhibitors.
Susan Escudier, MD, FACP
February 17th 2025

Addressing Financial Toxicity and Clinical Trial Disparities in Community Oncology

Hayden E. Klein Susan Escudier, MD, FACP
Susan Escudier, MD, FACP, explains some of the ways Texas Oncology mitigates financial toxicity and improve clinical trial access for underserved patients.
Powles Highlights “Transformative” Benefit of EV Plus Pembro While Sharing Long-Term Data for EV-302
February 15th 2025

Powles Highlights “Transformative” Benefit of EV Plus Pembro While Sharing Long-Term Data for EV-302

Mary Caffrey
The lead investigator for EV-302 said not long ago, survival of 12 to 14 months in this type of bladder cancer was considered an achievement; in this study, median overall survival was 34 months after treatment with enfortumab vedotin (EV) and pembrolizumab (pembro).
Analysis Looks at Benefits, Toxicity of ADC Combinations in Advanced Bladder Cancer
February 15th 2025

Analysis Looks at Benefits, Toxicity of ADC Combinations in Advanced Bladder Cancer

Mary Caffrey
City of Hope's Salvador Jaime-Casas, MD, discusses a systematic review of recent trials examining objective response rate and adverse events of antibody-drug conjugate (ADC) combinations in advanced urothelial cancer.
Screenshot of an interview with Evangelia Vlachou, MD
February 14th 2025

Enfortumab Vedotin With or Without Pembrolizumab Delivers Promising Responses for Upper Tract Urothelial Cancer

Laura Joszt, MA Evangelia Vlachou, MD
Enfortumab vedotin with or without pembrolizumab offers disease control benefits for patients with upper tract urothelial cancer, said Evangelia Vlachou, MD, of Johns Hopkins Medicine.
Screenshot of an interview with Barry Goy, MD
Published: February 14th 2025 | Updated: February 14th 2025

Receiving NADT for 6 Months Doesn’t Impact Outcomes in Intermediate-Risk Prostate Cancer After EBRT

Laura Joszt, MA Barry Goy, MD
Adding 6 months of neoadjuvant deprivation therapy (NADT) doesn’t seem to add any benefit for patients with intermediate-risk prostate cancer treated with external-beam radiation therapy (EBRT), according to 15-year outcomes presented by Barry Goy, MD, of Kaiser Permanente.
Metastatic urothelial carcinoma. | Image Credit: MdBabul - stock.adobe.com
February 13th 2025

ASCO GU Posters Address Cost-Effectiveness, Implementation Barriers for New mUC Treatments

Cameron Santoro
Health systems are facing hurdles to implementing new and effective metastatic urothelial carcinoma (mUC) therapies into practice due to high costs and a lack of targeted initiatives to aid health care providers with integration.
Positive OS for Bladder Cancer Combo, Biomarkers on Tap at ASCO GU 2025
February 11th 2025

Positive OS for Bladder Cancer Combo, Biomarkers on Tap at ASCO GU 2025

Mary Caffrey
Data on enfortumab vedotin plus pembrolizumab for advanced bladder cancer, along with updates on antibody-drug conjugates, biomarkers, and other cancer treatments, will be highlighted at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU).
Debra Patt, MD, PhD, MBA, MPH
February 10th 2025

The “Secret Sauce” in Oncology: The Partnership Between Clinicians and AI

Mary Caffrey Debra Patt, MD, PhD, MBA, MPH
“To error is human, and also to error is in machine learning,” said Debra Patt, MD, PhD, MBA, MPH.
Burning cigarette | Image Credit: nikkytok - stock.adobe.com
February 10th 2025

Pain Linked to Greater Cigarette, E-Cigarette, Cannabis Use Among Cancer Survivors

Brooke McCormick
These new data highlight the need for improved pain management among patients with cancer and survivors.
Terra Wonsettler, PharmD, MBA | Image credit: Evolent
February 7th 2025

Evolent’s Wonsettler Sees Outcomes-Based Reimbursement as “A Healthy Tool”

Terra Wonsettler, PharmD, MBA Interview by Mary Caffrey
Terra Wonsettler, PharmD, MBA, vice president of pharmacy for Evolent, discusses the recent HHS OIG report that stemmed from the 2021 FDA approval of aducanumab (Aduhelm) and use of the accelerated approval pathway.
Doctor showing patient lung x-ray. | Image credit: Dragana Gordic – stock.adobe.com
February 7th 2025

Study Finds Declining SCLC Incidence, but Stagnant Survival Rates

Hayden E. Klein
SEER data show that small cell lung cancer (SCLS) incidence has steadily declined due to reduced smoking rates, but survival outcomes have seen only minimal improvement, underscoring the need for more effective treatments.
AJMC
February 7th 2025

Hospitalization Patterns Among Older Patients With Cancer With and Without Dementia

Zhigang Xie, PhD, MPA Hanadi Y. Hamadi, PhD Elissa Barr, PhD Beomyoung Cho, PhD, MPH Shraddha Patel, MPH Young-Rock Hong, PhD, MPH
Dementia was more prevalent in older patients with some cancer types, and comorbid dementia in this population was associated with unplanned or unnecessary hospitalization.
Older man after skin cancer surgery with bandage on face | Image credit: steheap – stock.adobe.com
February 7th 2025

Keratinocyte Skin Cancer Surgery Considered Safe, Effective in Older Patients

Hayden E. Klein
A single-center study suggests the surgery is safe and effective even when tumors are large or located in high-risk areas.
Flatiron Health, Exact Sciences Announce Deal to Speed Evidence Generation With MRD Test
February 6th 2025

Flatiron Health, Exact Sciences Announce Deal to Speed Evidence Generation With MRD Test

AJMC Staff
The companies announced the deal in a statement February 5, 2025, noting that the first patient had enrolled in a prospective clinical study using the test to monitor cancer recurrence across multiple solid tumor types.
Clayton Irvine, PharmD, MBA, MS.
February 6th 2025

Addressing Cancer Treatment Costs With Patient-Provider Communication

Cameron Santoro Clayton Irvine, PharmD, MBA, MS
Clayton Irvine, PharmD, MBA, MS, senior manager of oncology care at Mayo Clinic, emphasizes the need for health care providers to balance quality patient care with rising costs by openly discussing financial implications with patients and educating themselves on cost-effective treatments.
Debra Patt, MD, PhD, MBA, MPH
February 6th 2025

Dr Debra Patt on Prior Authorization: Something Has to Give

Mary Caffrey Debra Patt, MD, PhD, MBA, MPH
Debra Patt, MD, PhD, MBA, MPH, warns that prior authorization barriers are delaying critical cancer treatments and urges a regulatory fix for Stark Law restrictions on mailing oral oncolytics.
AI concept of cancer vaccine | Image credit: radekcho - stock.adobe.com
February 5th 2025

Promising Cancer Vaccine Boosts Hope for Stage III and IV Kidney Cancer

Pearl Steinzor
All patients involved in the phase 1 trial of a personalized cancer vaccine for high-risk stage III/IV kidney cancer showed a successful anticancer immune response.
COA Offers “Prescription” for Tackling Rising Costs, Loss of Patient Access in Cancer Care and Beyond
February 5th 2025

COA Offers “Prescription” for Tackling Rising Costs, Loss of Patient Access in Cancer Care and Beyond

Mary Caffrey
The 5-part plan focuses on issues that have been calling cards for the Community Oncology Alliance (COA) in recent years, which gained traction in the last Congress and show up regularly on lists of the most pressing problems in health care.
Debra Patt, MD, PhD, MBA, MPH
February 4th 2025

Dr Debra Patt Pushes for PBM Reform and Physician Reimbursement Fixes

Mary Caffrey Debra Patt, MD, PhD, MBA, MPH
Debra Patt, MD, PhD, MBA, MPH, emphasizes advocacy for pharmacy benefit manager (PBM) reform, physician reimbursement, and sustainable policy solutions to improve access to community cancer care.
Older patient exercising | image credit: MAGIC - stock.adobe.com
February 4th 2025

New Findings Strengthen Case for Exercise Therapy in Cancer Care

Kyle Munz
A new meta-analysis adds to the body of literature promoting the benefits of exercise for patients with cancer.
Oscar B. Lahoud, MD, and Kasey Bond, MPH
February 4th 2025

Addressing Cancer Care Barriers Through Community Outreach and Support

Maggie L. Shaw Oscar B. Lahoud, MD Kasey Bond, MPH
February 4 is World Cancer Day, and in these interviews with our Strategic Alliance Partner, NYU Langone Health, we learn about the importance of forming strong relationships with the communities you are located in and with whom you work to optimize cancer-related outcomes.
Oncology Research | Image credit: iStock
January 30th 2025

Oncology R&D Will Follow Divergent Paths, Experts Say at JPM Event

Mary Caffrey
A panel discussion during the JPMorgan conference earlier this month examined where oncology drug development is headed, driven in part by advances in diagnostic testing.
FDA Approval | Image credit: wladimir1804 - stock.adobe.com
January 29th 2025

FDA Approves Companion Diagnostic for Tovorafenib in BRAF-Altered Pediatric Low-Grade Glioma

Ashling Wahner
Tovorafenib generated durable drug holiday responses in pediatric patients with BRAF-altered relapsed/refractory low-grade glioma.
Chelsee Jensen, PharmD, BCPS.
January 29th 2025

Optimizing Oncology Drug Use While Mitigating Shortages

Cameron Santoro Chelsee J. Jensen, PharmD, BCPS
Chelsee Jensen, PharmD, BCPS, senior pharmacy specialist at Mayo Clinic, suggests that medical providers can reduce patient and system costs by optimizing the use of generics and biosimilars, which offer lower costs without compromising safety and efficacy.
Kirollos Hanna, PharmD
January 28th 2025

Balancing Longevity, Quality, and Cost in Oncology Care

Kyle Munz Kirollos Hanna, PharmD
Kirollos Hanna, PharmD, BCPS, BCOP, FACCC, director of pharmacy at Minnesota Oncology, discusses how the prospect of patient longevity, amidst advancing therapeutics, factors into oncology care.
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