Oncology

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The investigators found that tumor mutational burden and PD-L1 expression, which have traditionally been used as indicators of immunotherapy efficacy, had little predictive value for survival in this cohort. | Image credit: Dragana Gordic - stock.adobe.com
Predictive Model Forecasts Advanced NSCLC Outcomes

August 14th 2025

The newly developed model has an area under the curve of 0.807 for predicting progression-free survival.

Dordaviprone is indicated for recurrent H3 K27M-mutant diffuse midline glioma, an ultra-rare, aggressive brain tumor primarily affecting children. | Image credit: wladimir1804 - stock.adobe.com
FDA Approves Dordaviprone as First and Only Treatment for Aggressive Form of Glioma

August 6th 2025

Gen Li, PhD, MBA, president and founder of Phesi
Real-World Data, Digital Patient Profiles Are Revolutionizing Trial Design, Patient Recruitment: Gen Li, PhD, MBA

August 4th 2025

Value-based care. | Image Credit: irissca - stock.adobe.com
Legal Navigation Services Key to Addressing Disparities in Cancer Care

July 31st 2025

Radiotherapy can work synergistically with immunotherapy by reprogramming the tumor microenvironment. | Image credit: Crystallight-stock.adobe.com
Brain Radiotherapy Plus ICIs Boost Survival in SCLC With Brain Metastases

July 30th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations
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August 18th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
August 18th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

Dr Christopher Kane on Robotic Procedures in Prostate Cancer
February 10th 2018

Dr Christopher Kane on Robotic Procedures in Prostate Cancer

Robotic procedures have really exploded in prostate cancer, said Christopher Kane, MD, professor of urology, University of California, San Diego. Robotic radical prostatectomy is now the most common way a radical prostatectomy is done in the United States.
Eligibility Requirements Exclude Black Patients From Prostate Cancer Clinical Trials
February 10th 2018

Eligibility Requirements Exclude Black Patients From Prostate Cancer Clinical Trials

Kaitlynn Ely
Black patients with prostate cancer are underrepresented in clinical trials due to eligibility requirements that exclude patients with benign ethnic neutropenia, according to a new study published in JAMA Oncology.
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February 10th 2018

Use of Biomarkers to Identify Patients, Therapies for Neoadjuvant Chemotherapy

Jaime Rosenberg
During a session at the 2018 Genitourinary Cancers Symposium, Peter Black, MD, professor, department of urologic sciences, University of British Columbia, discussed using molecular subtypes, the Coxen model, and gene mutations to select patients and therapies for neoadjuvant chemotherapy.
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February 10th 2018

Combining Radiation and Immunotherapy in Patients With Bladder Cancer

Jaime Rosenberg
During a session at the 2018 Genitourinay Cancers Symposium, Abhishek Solanki, MD, MS, assistant professor, radiation oncology, Loyola University of Chicago discussed the role of immunotherapy in patients undergoing radiation therapy for bladder cancer.
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February 10th 2018

Guidelines for Management of Muscle-Invasive Bladder Cancer

Jaime Rosenberg
With new guidelines on how to treat and manage muscle-invasive bladder cancer, Jeffrey Holzbeierlein, MD, FACS, professor of urology, director of urologic oncology, interim chair of the department of urology, University of Kansas Health System, provided insight into how the guidelines have changed the management of the disease at the 2018 Genitourinary Cancers Symposium.
This Week in Managed Care: February 9, 2018
February 9th 2018

This Week in Managed Care: February 9, 2018

This week, the top managed care stories included Indiana being approved as the second state to implement work requirements in Medicaid; research found 5-year survival rates for cancer are increasing; coverage from the American Society of Clinical Oncology's 2018 Genitourinary Symposium.
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February 9th 2018

Is There Evidence for Local Treatment for Newly Diagnosed Metastatic Prostate Cancer?

Jaime Rosenberg
During a session at the 2018 Genitourinary Cancers Symposium, 2 doctors debate whether there is existing evidence for local treatment for patients newly diagnosed with metastatic disease.
Dr Joe O'Sullivan on Molecular Therapies in Prostate Cancer
February 9th 2018

Dr Joe O'Sullivan on Molecular Therapies in Prostate Cancer

For the first time, molecular therapies, such as radium-223, provide a survival-prolonging agent for men with advanced prostate cancer affecting the bone, explained Joe O'Sullivan, MD, FRCR, clinical professor, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast.
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February 9th 2018

Osteomimicry May Contribute to Uptake of Radium-223 Within Bone Metastases for Patients With mCRPC

Jaime Rosenberg
Osteomimicry may contribute to the uptake of radium-223 within bone metastases and may subsequently enhance the therapeutic benefit of radium-223, according to an abstract presented by Andrew Armstrong, MD, associate professor of medicine, Duke University School of Medicine, at the 2018 Genitourinary Cancers Symposium.
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February 9th 2018

Apalutamide Significantly Improved Metastasis-Free Survival in Men With nmCRPC

Jaime Rosenberg
Apalutamide significantly improved median metastasis-free survival by 2 years in men with nonmetastatic castrate-resistant prostate cancer (nmCRPC), according to study results presented by Eric Jay Small, MD, MD, FASCO, chief of the division of hematology and oncology in the department of medicine at the University of California, San Francisco (UCSF), deputy director of the UCSF Helen Diller Family Comprehensive Cancer Center, and professor in residence in the Department of Medicine and Department of Urology, at the 2018 Genitourinary Cancers Symposium.
Long-Term Follow-Up of CAR T in ALL Indicates Early Treatment Extends Survival
February 9th 2018

Long-Term Follow-Up of CAR T in ALL Indicates Early Treatment Extends Survival

Laura Joszt, MA
A long-term follow-up analyzing the toxic effects and results from a phase 1 clinical trial of adult patients with relapsed B-cell acute lymphoblastic leukemia (ALL) who were treated with CD19-specific chimeric antigen receptor (CAR) T cells found patients with low disease burden had a longer medial overall survival and a lower incidence of toxicity.
Atezolizumab Treatment Safe and Effective in Metastatic Urothelial Cancer Patients
February 8th 2018

Atezolizumab Treatment Safe and Effective in Metastatic Urothelial Cancer Patients

Kaitlynn Ely
Patients with metastatic urothelial cancer treated with atezolizumab monotherapy demonstrated tolerability for the drug and general ability to manage adverse effects, according to a study published in JAMA Oncology.
ACCC Survey Recognizes Major Challenges Cancer Centers Experience
February 8th 2018

ACCC Survey Recognizes Major Challenges Cancer Centers Experience

Kaitlynn Ely
While an increasing number of immunotherapies are reaching market and becoming available, cancer centers feel unprepared to prescribe these treatments and handle adverse events and side effects, according to findings from a new survey from the Association of Community Cancer Centers.
Terrill Jordan on Implementing OCM: Take It Step by Step
February 6th 2018

Terrill Jordan on Implementing OCM: Take It Step by Step

Before undertaking something like implementing the Oncology Care Model, practices should understand the scope of the project and the overall importance it can have for patient care, said Terrill Jordan, CEO of Regional Cancer Care Associates.
Cancer Mortality Statistics and Disparities in the US: Dr Patricia Salber Interviews Dr Otis Brawley
February 6th 2018

Cancer Mortality Statistics and Disparities in the US: Dr Patricia Salber Interviews Dr Otis Brawley

There has been some good news regarding cancer: a decline in the death rate and in new cancer diagnoses for men. However, the latest findings also highlight what still needs to be worked on, according to Otis W. Brawley, MD, MACP, FASCO, FACE, chief medical and scientific officer for the American Cancer Society.
Dr Peter Aran Discusses Year 1 Feedback on OCM
February 5th 2018

Dr Peter Aran Discusses Year 1 Feedback on OCM

When you have constant evolving contract, there are changes, and so some of the feedback I’m getting is that sometimes it’s hard to keep up with the changes, said Peter Aran, MD, medical director of Population Health Management at Blue Cross Blue Shield of Oklahoma.
Dr Adam Brufsky: Choosing a Therapy for Breast Cancer Patients
February 4th 2018

Dr Adam Brufsky: Choosing a Therapy for Breast Cancer Patients

There are a number of treatment choices available to treat patients with breast cancer and diagnostic tests can assist in the decision making, according to Adam M. Brufsky, MD, PhD, co-director of the Comprehensive Breast Cancer Center at University of Pittsburgh.
5-Year Survival Rates for Patients With Cancer Worldwide
February 4th 2018

5-Year Survival Rates for Patients With Cancer Worldwide

Jaime Rosenberg
CONCORD-3 includes the records of 37.5 million patients diagnosed with cancer from 2000 to 2014, 322 population-based cancer registries in 71 countries and territories, and data on patients' vital status at least 5 years following diagnosis.
Podcast: This Week in Managed Care—State of the Union and Other Health News
February 3rd 2018

Podcast: This Week in Managed Care—State of the Union and Other Health News

Laura Joszt, MA
Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.
This Week in Managed Care: February 2, 2018
February 2nd 2018

This Week in Managed Care: February 2, 2018

This week, the top managed care news included President Donald Trump vowing to lower drug prices during his State of the Union address; 3 corporate giants joined forces on healthcare; and CAR T-cell therapy was named the cancer advance of the year.
AJMC® in the Press, February 2, 2018
February 2nd 2018

AJMC® in the Press, February 2, 2018

AJMC Staff
Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.
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February 2nd 2018

Quality of Life

Researchers at the 59th Annual Meeting and Exposition of the American Society of Hematology in Atlanta, Georgia presented studies investigating the quality of life associated with various oncologic diseases.
New Study Analyzes Need for Biopsies During Follow-Up Care in Breast Cancer
February 2nd 2018

New Study Analyzes Need for Biopsies During Follow-Up Care in Breast Cancer

Kaitlynn Ely
New research on breast cancer biopsies and counseling after treatment will allow surgeons to have more meaningful conversations with their patients, according to a study published in JAMA Surgery.
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February 2nd 2018

Cost of Care

Various presenters at the 59th Annual Meeting of the American Society of Hematology in Atlanta, Georgia discussed the cost of care involved in several different cancer treatments.
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February 1st 2018

New Treatment Paradigm Supersedes ABVD in Advanced Hodgkin Lymphoma: The ECHELON-1 Study

Surabhi Dangi-Garimella, PhD
Coverage from the 59th Annual Meeting and Exposition of the American Society of Hematology, December 9-12, 2017.
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February 1st 2018

Ibrutinib Is More Effective Than Stem-Cell Transplant in Patients With Form of Chronic Leukemia

Jaime Rosenberg
Coverage from the 59th Annual Meeting and Exposition of the American Society of Hematology, December 9-12, 2017.
E-Cigarette Smoke Poses Threat to DNA Repair Activity
February 1st 2018

E-Cigarette Smoke Poses Threat to DNA Repair Activity

Kaitlynn Ely
E-cigarette smokers have a high risk of developing lung and bladder cancer, as well as certain heart diseases due to carcinogenic e-cigarette smoke (ECS), according to a study published in the Proceedings of the National Academy of Sciences.
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February 1st 2018

Treatment-Free Remission and Preventing Cardiotoxicity: The Future of CML Care

Surabhi Dangi-Garimella, PhD
Coverage from the 59th Annual Meeting and Exposition of the American Society of Hematology, December 9-12, 2017.
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February 1st 2018

Clonal Expansion and Aging Fuel the Development of Neoplasms, Say Experts at ASH

Surabhi Dangi-Garimella, PhD
Coverage from the 59th Annual Meeting and Exposition of the American Society of Hematology, December 9-12, 2017.
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February 1st 2018

AJMC®tv Interviews, January 2018

At the American Society of Hematology’s 59th Annual Meeting and Exposition, healthcare industry leaders sat down with The American Journal of Managed Care® to speak about what’s new and important about changes in healthcare. Access the video clips at ajmc.com/conferences/ash-2017.
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