Oncology

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Patients in the cemiplimab group had superior disease-free survival vs placebo. | Image credit: Medical Works - stock.adobe.com

Cemiplimab Improves Disease-Free Survival in High-Risk, Advanced CSCC

By Jared Kaltwasser

June 13th 2025

Cemiplimab improved disease-free survival in patients with high-risk cutaneous squamous cell carcinoma (CSCC) and performed well in patients with advanced CSCC in the real-world setting.

The approval covers use of pembrolizumab as a single agent in the neoadjuvant setting, followed by adjuvant treatment with pembrolizumab in combination with radiotherapy with or without cisplatin after surgery, and then continued as a single agent. | Image credit: wladimir1804-stock.adobe.com

FDA Approves Perioperative Pembrolizumab in Resectable HNSCC

June 13th 2025

FDA approval-Olivier Le Moal-stock.adobe.com.jpeg

Mitomycin Intravesical Solution Gains FDA Approval for Recurrent Low-Grade NMIBC

By Giuliana Grossi

June 12th 2025

AJMC

Utilization and Costs Among Oncologists Participating in a Private Insurance Shared Savings Model

By Brigham Walker, PhD
Lalan Wilfong, MD

June 11th 2025

The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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September 29th 2015

The Patient Will See You Now: Part 1

My visit to the gynecologist's office following treatment for breast cancer and a subsequent reconstructive surgery was a rude awakening.

September 28th 2015

Results of Gene Panel Test Can Determine Need for Chemotherapy in Breast Cancer

Surabhi Dangi-Garimella, PhD

A prospective study that enrolled more than 10,000 women with hormone-receptor—positive, HER2-negative breast cancer has found that their response to a 21-gene test can identify patients who can avoid chemotherapy.

Dr Amy Davidoff Highlights the Benefits of Palliative Care, Discusses Biosimilars

September 28th 2015

Dr Amy Davidoff Highlights the Benefits of Palliative Care, Discusses Biosimilars

Palliative care should enter into the discussion with patients with cancer as early as possible as it can manage symptoms from therapy or it can provide comfort to patients who cannot afford or choose to forgo therapy, said Amy Davidoff, PhD, MS. Plus, she discusses the impact biosimilars may have on therapy costs.

September 28th 2015

Distinct Molecular Tumor Profile in Younger CRC Patients Recognized

Surabhi Dangi-Garimella, PhD

Data presented at the ongoing European Cancer Congress has identified a different epigenetic profile in the tumors of younger colorectal cancer patients, information that can help improve treatment options in this population.

Dr Ira Klein Discusses the Use of Fee-for-Service in Oncology

September 27th 2015

Dr Ira Klein Discusses the Use of Fee-for-Service in Oncology

Although CMS has introduced a strict timeline to move to value-based payments, its new Oncology Care Model is partially relying on fee-for-service, and that's a good thing in the case of oncology, said Ira Klein, MD, MBA, senior director of quality, Strategic Customer Group at The Janssen Pharmaceutical Companies of Johnson & Johnson.

This Week in Managed Care: September 26, 2015

September 26th 2015

This Week in Managed Care: September 26, 2015

Top managed care stories this week include the follow up to the National Academy of Medicine's groundbreaking "To Err Is Human" report, findings on the sharp increase in deductibles, and discussing costs in cancer care.

September 25th 2015

First-Ever Therapeutic HPV Vaccine Promising Against Cervical Cancer

Surabhi Dangi-Garimella, PhD

Developed by Inovio Pharmaceuticals, the vaccine has shown the potential to impact precancerous cervical lesions.

September 25th 2015

Results at ESMO Focus on Companion Diagnostics, Avoiding Overtreatment in Prostate Cancer

Posters focus on next-generation sequencing ovarian cancer and identify candidates for treatment with PARP inhibitors.

September 25th 2015

Molecularly Targeted SHIVA Trial Fails to Improve Outcomes in Refractory Cancer Patients

Surabhi Dangi-Garimella, PhD

The trial, conducted in France, was a proof-of-concept study to evaluate the efficacy of targeted agents in patients, based on their tumor's molecular profile.

September 25th 2015

The Dawning of Democratized Cancer Care

Emmanuel F. Petricoin III, PhD

Innovative trials offer the promise that patients can be treated in their own communities instead of traveling to faraway cancer centers.

September 24th 2015

Startup's Direct-to-Consumer Genetic Test Receives FDA Attention

Surabhi Dangi-Garimella, PhD

In a letter to Pathway Genomics, the FDA has expressed interest in discussing the company's validation strategy as well as evaluating data on clinical sensitivity and specificity of the CancerIntercept Detect test.

September 24th 2015

ASCO President Julie Vose, MD, to Give Keynote at AJMC's Patient-Centered Oncology Care Meeting

The fourth annual meeting of Patient-Centered Oncology Care, set for November 19-20, 2015, in Baltimore, Maryland, will feature a premiere multi-stakeholder lineup where leading payers, providers, and leaders from pharma will discuss how to deliver value-based care as cost of breakthrough therapies continues to climb. Julie Vose, MD, MBA, FASCO, the president of the American Society of Clinical Oncology, will give the keynote address.

September 24th 2015

USPSTF Recommendation May Increase Risk for Prostate Cancer

Surabhi Dangi-Garimella, PhD

A study published in The Journal of Urology suggests the Grade D recommendation for PSA-based screening may place those with intermediate and high-risk prostate cancer at risk.

Dr Julie Vose on the Importance of Attending PCOC15

September 23rd 2015

Dr Julie Vose on the Importance of Attending PCOC15

Julie Vose, MD, MBA, FASCO, president of the American Society of Clinical Oncology and keynote speaker at Patient-Centered Oncology Care 2015, explains the importance of the meeting and how patients benefit when a diverse set of stakeholders come together in one room.

September 23rd 2015

Dissecting the Patient Perception of FDA's Breakthrough Designation

Surabhi Dangi-Garimella, PhD

A JAMA Internal Medicine study found the terms "breakthrough" and "promising" raised people's expectations on the drug's performance as opposed to when the drugs were described as having met the breakthrough criteria.

September 23rd 2015

Clinton Seeks Cap on Drug Expenses, Would Let Medicare Negotiate

Mary K. Caffrey

Hillary Clinton unveiled a plan in Iowa that features a $250 per month cap on drug costs for patients with chronic conditions. This comes 2 weeks after her chief rival for the Democratic nomination, US Senator Bernie Sanders of Vermont, introduced a bill aimed at reining in drug costs. In the summer, The American Journal of Managed Care said polling showed that rising drug costs were poised to become a major issue in the 2016 campaign.

September 23rd 2015

Physicians Believe in Biosimilars but Lack Awareness, Says Report by Quantia

Surabhi Dangi-Garimella, PhD

A white paper released by QuantiaMD has identified a lack of awareness and education about biosimilars among prescribing physicians.

September 22nd 2015

Lonsurf Granted Approval for Advanced Colorectal Cancer

Surabhi Dangi-Garimella, PhD

Lonsurf (TAS-102) is an oral 2-drug combination pill that is intended for metastatic colorectal cancer patients who have failed on chemotherapy and biological therapy.

September 22nd 2015

AstraZeneca Believes Open Innovation Will Uncover Novel Anticancer Combinations

Surabhi Dangi-Garimella, PhD

AstraZeneca hopes to harness the open source platform of the DREAM challenge, releasing preclinical data to discover synergistic cancer drug combinations.

September 21st 2015

Reimbursement Challenges Persist as Oncologists Embrace Value-Based Care, ACCC Survey Finds

Surabhi Dangi-Garimella, PhD

Among other challenges faced by cancer care centers, reimbursement for providing patient-centered care services remains at the top, a survey by The Association of Community Cancer Centers found.

September 21st 2015

New FDA Nominee May Face Challenges for His Pharma Ties

Surabhi Dangi-Garimella, PhD

A report in The New York Times identifies challenges that could be raised based on Califf's past associations with the drug industry.

September 20th 2015

About Half with Cancer Want to Discuss Care Costs with Physician, But Fewer Do, Study Finds

Rising costs in cancer care, especially for new therapies, have gained attention in recent years. However, a study just published in The American Journal of Managed Care finds about half of patients are interested in discussing cost on the front end, but only a minority actually have a cost discussion with their oncologist.

Dr Clifford Goodman Peers 20 Years Into the Future of NCCN

September 20th 2015

Dr Clifford Goodman Peers 20 Years Into the Future of NCCN

As the National Comprehensive Cancer Network (NCCN) celebrates 20 years, Clifford Goodman, PhD, takes a look at how NCCN will evolve after another 20 years, including constant streaming of real-time data and more patient involvement.

This Week in Managed Care: September 19, 2015

September 19th 2015

This Week in Managed Care: September 19, 2015

The top stories in managed care include the nomination for the next FDA commissioner, a report reveals cancer drugs are driving growth in the 340B program more than initially thought, and nearly half a billion in ACA funds are made available to health centers.

September 18th 2015

Tumor Response Signature to Bevacizumab Recognized in HER2-Negative Breast Cancer

Surabhi Dangi-Garimella, PhD

A collaborative team of researchers have been able to identify a gene signature that can predict how HER2-negative breast cancer patients would respond to treatment with bevacizumab.

September 18th 2015

NIH Approves Blueprint for Obama's Precision Medicine Initiative

Surabhi Dangi-Garimella, PhD

The path to President Obama's Precision Medicine Initiative has been paved as is evident from a report released by a Working Group convened by the National Institutes of Health.

September 17th 2015

MAF Regulates Bone Metastases in Breast Cancer

Surabhi Dangi-Garimella, PhD

Scientists in Spain have identified gene mutations that trigger bone metastasis in breast cancer patients.

September 17th 2015

The Cost Conundrum in Cancer Care

Surabhi Dangi-Garimella, PhD

At the recently held NCCN healthcare policy summit in Washington, DC, experts delved into various models being evaluated to reduce healthcare utilization in oncology care.

September 16th 2015

An Open Discussion on Value in Oncology Care at the NCCN Policy Summit

Surabhi Dangi-Garimella, PhD

Healthcare policy makers, payers, medical centers, and patient representatives shared the dais as they discussed The Value Proposition in oncology.

September 16th 2015

Bim Expression Could Predict Patient Response to PD-1 Blockade, Mayo Clinic Study Finds

Surabhi Dangi-Garimella, PhD

Metastatic melanoma patients treated with pembrolizumab responded better if their T cells had a higher level of Bim expression.

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