Oncology

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Patients in the cemiplimab group had superior disease-free survival vs placebo. | Image credit: Medical Works - stock.adobe.com

Cemiplimab Improves Disease-Free Survival in High-Risk, Advanced CSCC

By Jared Kaltwasser

June 13th 2025

Cemiplimab improved disease-free survival in patients with high-risk cutaneous squamous cell carcinoma (CSCC) and performed well in patients with advanced CSCC in the real-world setting.

The approval covers use of pembrolizumab as a single agent in the neoadjuvant setting, followed by adjuvant treatment with pembrolizumab in combination with radiotherapy with or without cisplatin after surgery, and then continued as a single agent. | Image credit: wladimir1804-stock.adobe.com

FDA Approves Perioperative Pembrolizumab in Resectable HNSCC

June 13th 2025

FDA approval-Olivier Le Moal-stock.adobe.com.jpeg

Mitomycin Intravesical Solution Gains FDA Approval for Recurrent Low-Grade NMIBC

By Giuliana Grossi

June 12th 2025

AJMC

Utilization and Costs Among Oncologists Participating in a Private Insurance Shared Savings Model

By Brigham Walker, PhD
Lalan Wilfong, MD

June 11th 2025

The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Use of Molecular Tests That Assess Risk of Recurrence

January 16th 2015

Use of Molecular Tests That Assess Risk of Recurrence

January 15th 2015

Spanish Team Identifies Gene Variant Responsible for Susceptibility to Peripheral Neuropathy

The authors of the research say that this information could be especially valuable for the Spanish population: "Even though these variants are rare or not frequent in the population, their frequency is greater in Spain than in other countries."

January 15th 2015

Metabolic Syndrome A Significant Risk Factor in Endometrial Cancer, Study Finds

Overall, metabolic syndrome was associated with a 39 percent to 103 percent increased risk of endometrial cancer in women 65 and older, according to the study.

January 15th 2015

Patients With Metastatic Colorectal Cancer Having Less Surgery, Yet Survival Rates Improving

With the dawn of the modern era of new chemotherapeutic and biologic agents available for managing their disease, patients with metastatic colorectal cancer are undergoing less surgery for the removal of their primary tumors.

January 15th 2015

Can We Follow the European Model to Curb Drug Costs, Asks Dr Peter Bach

In an Ope-Ed in The New York Times , Peter Bach, MD, from the Memorial Sloan Kettering Cancer Center, questions the rising drug prices and contemplates solutions.

January 14th 2015

ASCO Staff Raising Healthcare Issues with Federal and State Legislators

Members of the ASCO Government Relations Committee are busy meeting Members of Congress as well as State Affiliates to address a number of healthcare issue early in the year.

January 14th 2015

Cancer Treatments the Next Big Area for Cost Saving Opportunities

Laura Joszt, MA

Involving the pharmacy benefits manager earlier in the decision-making process could lead to cost savings on cancer treatments, Express Scripts Chief Executive Officer George Paz said at the J.P. Morgan Healthcare Conference in San Francisco, California.

January 14th 2015

Diagnostic Testing Guidelines for Lung Cancer to Be Revised

In addition to recommendations on alternate techniques, the revised guideline, being jointly developed by CAP, IASLC, and AMP, will also include testing for emerging biomarkers in lung cancer.

January 14th 2015

Express Scripts Wants Early Discussions to Help Lower Treatment Costs

After their decision to include Abbvie's triple combination for hepatitis C on their formulary, over Gilead's more expensive regimens, Express Scripts indicated at the J. P. Morgan Healthcare Conference that they'll continue the stance of choosing treatments that are equally effective but save costs, especially in cancer.

January 13th 2015

"Choose Wisely" in Rectal Cancer a Retrospective Study Indicates

The retrospective analysis of 145 patients with stage 2-3 rectal cancer found that the "wait and watch" approach, instead of surgery, in patients treated with chemotherapy might work just as well when measuring survival as an outcome.

January 13th 2015

Pharma Giants to Collaborate on Immuno-oncology Regimens

Merck and Eli Lilly have entered an agreement to collaborate on clinical trials to evaluate the former's recently approved PD-1 inhibitor, Keytruda (pembrolizumab) in combination with Lilly's oncology agents in several clinical trials targeting multiple tumor types.

January 13th 2015

Study Highlights Need to Reduce Global Teen Exposure to Second-hand Smoke

The study evaluated data collected through a global collaboration between research institutes in the United States, India, and Africa. Study results pointed to a high rate of exposure of non-smoking teenagers to second-hand smoke, both at home and outside.

January 12th 2015

Cancer Survivors Identify Lingering Medical, Financial Troubles

Laura Joszt, MA

The number of cancer survivors may be on the rise, but they experience continuing issues that can impair their quality of life beyond 5 years of survival, according to a new study published in Cancer.

January 12th 2015

Pfizer Gains Access to 23andMe's Genetic Mine

23andMe is betting its growing troves of genetic data will prove essential to drug companies, medical researchers, and even health and wellness companies.

January 12th 2015

A New Target in Difficult-to-Treat Breast Cancer?

The pre-clinical study by researchers at the Wellcome Trust Sanger Institute in UK point to the gene BCL11A as a possible driver of this aggressive form of breast cancer.

January 12th 2015

Nivolumab Phase 3 Trial in NSCLC Stopped Early; Superior OS

Mid-trial evaluation by an independent Data Monitoring Committee found overall survival with Opdivo (nivolumab) in the Checkmate-017 trial was significantly better than the control arm. BMS now plans to submit results to the FDA for approval of the PD-1 inhibitor in lung cancer.

January 9th 2015

ASCO Backs the FDA on Regulating Lab-Based Diagnostics

In comments to the House Committee on Energy and Commerce, Health Subcommittee, ASCO strongly supported the FDA's resolution to rigorously regulate laboratory-developed tests.

January 9th 2015

Age Determines HPV Persistence in Men

The study, published in the journal Cancer Prevention Research found that HPV persisted for 12 months or more in men older than 45 years of age, which could increase their susceptibility to developing head and neck cancer.

January 9th 2015

Nanotechnology, Hailed in Biomedicine, Could Have Cardiac Effects, Study Finds

While nanotechnology has led to countless advancements, a group of Israeli researchers are now raising a flag of caution about its effects on our health. They say exposure to tiny silica-based particles can play a big role in increasing heart attack and stroke risks.

January 9th 2015

Controlling Cancer Metastases To Prevent Disease Progression

Research at Heildelberg University is targeting the production of tumor-promoting growth factors in endothelial cells to prevent metastasis. Pre-clinical results using this strategy in a mouse model reduced lung and bone metastases in treated mice and also improved survival over the control chemotherapy-treated animals.

January 8th 2015

NCCN and Flatiron to Collaborate for Improved Patient-Centered Care

A new collaboration between NCCN and Flatiron Health will provide the opportunity to analyze key quality and outcomes metrics and identify trends and patterns in the care of patients with cancer.

January 8th 2015

The Debate on HPV Screening in Cervical Cancer

Following FDA approval of a DNA test to detect the HPV virus last year, the medical community is split over which test is more appropriate as a primary screen for cervical cancer in women.

January 8th 2015

Leading Cancer Research Groups Call for US Regulation of E-Cigarettes

Mary K. Caffrey

ASCO and AACR called on the FDA to regulate e-cigarettes and other electronic nicotine delivery systems and for more research to occur to find out how long-term use affects health. Leaders of these groups said that e-cigarettes could cause nicotine addiction among teens, and CDC data show rising use of the products among middle- and high-schoolers.

January 8th 2015

A Relatively Safe Breast Cancer Combination Therapy Proves Effective

The study published in the New England Journal of Medicine found nearly 100% survival with adjuvant paclitaxel and trastuzumab.

January 7th 2015

ODAC Recommends First Biosimliar for Approval to the FDA

The investigational drug by Sandoz, filgrastim, a biological similar to Amgen's Neupogen, is already approved for use in more than 40 countries worldwide.

January 7th 2015

Night Shift Work Is Not Heart Healthy, Study Finds

A new study has identified an increased risk of lung cancer and heart disease in night shift workers, adding to the growing knowledge of health risks associated with those jobs.

January 7th 2015

Cancer: A Genetic Gamble

A paper published in Science Magazine this month, co-authored by a mathematician and a biologist, suggests that heredity and environmental factors account for only one-third of the risk for developing cancer. A majority of risk is associated with random mutations, a result of mistakes during normal cellular replication.

January 6th 2015

Cancer Patients Not Too Distressed by Advanced Directives

A study conducted at the humanities and medicine departments at Penn State College of Medicine in Hershey, Pennsylvania, found that there's never an ideal time to talk to cancer patients about end-of-life decisions, and most patients are not too disturbed by these discussions.

January 6th 2015

Nanotechnology for Surgical Success and Phototherapy in Cancer

Scientists at Oregon State University have developed fluorescent nanoparticles that can aid in the removal of malignant tumors and also kill any remaining malignant cancer cells.

January 5th 2015

Will Neupogen Prove the Poster Child for Increased Access to Cheaper Biosimilars?

If the biological developed by Novartis to imitate Amgen's Neupogen is approved by the FDA, it'd open floodgates as other biosimilars find their way to the FDA's doorsteps. The cheaper alternatives would prove a tremendous cost-saving to the healthcare industry.

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