Oncology

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Patients in the cemiplimab group had superior disease-free survival vs placebo. | Image credit: Medical Works - stock.adobe.com

Cemiplimab Improves Disease-Free Survival in High-Risk, Advanced CSCC

By Jared Kaltwasser

June 13th 2025

Cemiplimab improved disease-free survival in patients with high-risk cutaneous squamous cell carcinoma (CSCC) and performed well in patients with advanced CSCC in the real-world setting.

The approval covers use of pembrolizumab as a single agent in the neoadjuvant setting, followed by adjuvant treatment with pembrolizumab in combination with radiotherapy with or without cisplatin after surgery, and then continued as a single agent. | Image credit: wladimir1804-stock.adobe.com

FDA Approves Perioperative Pembrolizumab in Resectable HNSCC

June 13th 2025

FDA approval-Olivier Le Moal-stock.adobe.com.jpeg

Mitomycin Intravesical Solution Gains FDA Approval for Recurrent Low-Grade NMIBC

By Giuliana Grossi

June 12th 2025

AJMC

Utilization and Costs Among Oncologists Participating in a Private Insurance Shared Savings Model

By Brigham Walker, PhD
Lalan Wilfong, MD

June 11th 2025

The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

By Jared Kaltwasser

June 7th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

More News

January 3rd 2015

ACA Can Help Smokers Quit, Experts Write

A perspective published in the New England Journal of Medicine affirms that provisions of the Affordable Care Act will allow improved coverage of smoking cessation tools, which could be a big boost in the number of smokers planning to quit.

January 3rd 2015

More Than 1.5 Million Cancer Deaths Averted in Last 2 Decades

Rates of cancer deaths have declined 22% over the last 2 decades, which amounts to 1.5 million deaths averted, according to the annual cancer statistics report from the American Cancer Society.

January 3rd 2015

NICE Uses Comparitive Effectiveness for Nab-Paclitaxel in Pancreatic Cancer

NICE has published draft guidance which recommends that nab-paclitaxel given with gemcitabine should not be funded by the NHS for previously untreated metastatic pancreatic cancer, because its limited benefits compared to current treatments do not justify its cost.

January 1st 2015

A New Hope in Advanced Lung Cancer

Combining erlotinib with SBRT more than doubled the survival time of stage 4 lung cancer patients.

December 30th 2014

The Year in Review: Most-Read Stories of 2014

Laura Joszt, MA

With 2014 coming to a close, The American Journal of Managed Care is taking a look back at the most popular articles from this year. These most-read articles highlight the healthcare issues most important to providers, insurers, and policy makers.

December 28th 2014

Blackberry Competes With Apple for Healthcare Apps

Blackberry announced the product of their collaboration with NantHealth: a healthcare app for doctors and nurses who use their smartphones.

December 27th 2014

Gardasil 9 Approved for 5 Additional HPV Types

With this approval, the vaccine can effectively protect against 5 additional types of HPV than the parent Gardasil vaccine, thereby preventing the development of cervical, vulvar and vaginal cancers, based on a randomized clinical trial.

December 27th 2014

Immuno-Oncology Getting Closer to Being Personalized: Nature Study

The Nature letter published results showing that the monoclonal antibody targeting PD-1 had antitumor activity, but more importantly, the response was greater in patients overexpressing the PD-L1 receptor, thereby opening the doors for targeted therapy.

December 21st 2014

ASCO Releases Guidelines to Improve Patient Awareness and Participation in Phase I Trials

The American Society of Clinical Oncology called for greater access to and education about phase I clinical trials, the first-in-human studies of new agents designed to fight cancer.

December 21st 2014

Lanreotide Approved for Gastroenteropancreatic Neuroendocrine Tumors

The approval was based on the results of a clinical trial that demonstrated improved PFS in patients on lanreotide. While the median PFS in the placebo arm was 16 months, patients in the lanreotide arm had not yet reached median PFS at the time of analysis, and it was anticipated to extend beyond 22 months.

December 20th 2014

Bayer's Xofigo Gains NICE Approval

The National Institute for Health and Care Excellence has issued draft guidelines on using the drug in prostate cancer patients.

Treatment Decisions and Unmet Needs

December 17th 2014

Treatment Decisions and Unmet Needs

Anti-Androgens and Combination Regimens in CRPC

December 17th 2014

Anti-Androgens and Combination Regimens in CRPC

Early Indication of Androgen Deprivation Resistance

December 17th 2014

Early Indication of Androgen Deprivation Resistance

Diagnostic and Prognostic Biomarkers

December 17th 2014

Diagnostic and Prognostic Biomarkers

Episode 3 - The CHAARTED Study-Treatment of CRPC with Docetaxel

December 17th 2014

Episode 3 - The CHAARTED Study-Treatment of CRPC with Docetaxel

Episode 2 - Variability in Disease Course and Treatment Approach

December 17th 2014

Episode 2 - Variability in Disease Course and Treatment Approach

Episode 1 - Defining and Detecting CRPC

December 17th 2014

Episode 1 - Defining and Detecting CRPC

December 17th 2014

AJMC Session Traces Evolution of ACO Growth, Mental Health Delivery Models

How do ACOs reach the point of delivering both savings and better care? The recent online session of the ACO and Emerging Healthcare Delivery Coalition, sponsored by The American Journal of Managed Care, covered how ACOs evolve, how that process applies to oncology care, and how managed care can benefit from a better model for mental health delivery.

Alex Bastian Strives to Define Value in Care Better

December 16th 2014

Alex Bastian Strives to Define Value in Care Better

In order to reign in high costs of care in oncology, the healthcare community needs to be able to define value better, according to Alex Bastian, MBA, senior vice president at GfK.

December 15th 2014

UnitedHealth Launches Bundled Payment Program at MD Anderson

The pilot, which will has been launched for head and neck cancer patients, will include quality measures to ensure adequate patient care.

December 14th 2014

After Astra, Pfizer Taps Other Immuno-Oncology Markets

With the immuno-oncology field getting more intense, Pfizer continues its struggle to gain a foothold in the field. Following unsuccessful attempts to bid for AstraZeneca, Pfizer has now signed a deal with a Belgian company, iTeos Therapeutics.

December 13th 2014

How Should E-Cigarettes Be Regulated?

Should e-cigarettes be regulated he same way as cigarettes? Should marketing and sales restrictions be the same? Policy and health experts chime-in.

December 13th 2014

Hopkins Adapts to Prevent Cancer Risk of Uterine Morcellation

Just prior to the FDA guidance on the use of power morcellators, Johns Hopkins made public a new care plan for managing fibroids or hysterectomies in women over age 50 years.

December 13th 2014

Making a Case for Biomarkers in Cancer Immunotherapy

Immune response boosters in oncology, approved for melanoma so far, are being evaluated in several different cancer types. While the drugs perform well, there is a definite need to identify responsive patient cohorts.

December 13th 2014

One For Choosing Wisely in Breast Cancer

A study presented at the San Antonio Breast Cancer Symposium showed that Herceptin may not complement chemotherapy in breast tumors with a high level of immune infiltration.

December 12th 2014

Oncotype DX DCIS Can Predict Recurrence in Women With DCIS

Based on results presented at the ongoing San Antonio Breast Cancer Symposium, the gene panel was found to predict the risk of disease recurrence in women who had undergone breast conservation surgery for DCIS.

December 12th 2014

Cyramza Receives Extended Approval for Advanced NSCLC

The combination of (Cyramza) ramucirumab with docetaxel was today approved by the FDA for the treatment of advanced non-small cell lung cancer and in those who have been treated with platinum-based therapy.

December 12th 2014

Nashville Star Charles Esten Shares Personal Experience in Battling Rare Blood Disease

Actor and singer Charles Esten, whose daughter was diagnosed with leukemia when she was 2-and-a-half, shares the challenging and painful experiences of battling the disease.

December 11th 2014

Quality of End-of-Life Care for Cancer Patients: Does Home Hospice Care Matter?

Netta Bentur, PhD Shirli Resnizky, MA Ran Balicer, MD Tsofia Eilat-Tsanani, MD

Palliative principles were applied to the care of more HH patients than non-HH patients, but no differences were found in their utilization of healthcare services.

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