Oncology

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Patients with SCLC in the tarlatamab group had significantly longer overall survival, with a median of 13.6 months vs 8.3 months in the chemotherapy group. | Image credit: mi_viri - stock.adobe.com
Tarlatamab Improves SCLC Outcomes After Platinum Chemotherapy

June 19th 2025

Median overall survival was 5 months longer in patients with small cell lung cancer (SCLC) who received tarlatamab instead of chemotherapy after progression following platinum-based chemotherapy.

The data presented at ASCO reflect patients seen during 2 community health fairs designed to reach underserved populations in Georgia. | Image credit: NIKCOA - stock.adobe.com
Teledermatology Shows Promise to Reduce Disparities in Skin Cancer Screening

June 18th 2025

Patients in the cemiplimab group had superior disease-free survival vs placebo. | Image credit: Medical Works - stock.adobe.com
Cemiplimab Improves Disease-Free Survival in High-Risk, Advanced CSCC

June 13th 2025

The approval covers use of pembrolizumab as a single agent in the neoadjuvant setting, followed by adjuvant treatment with pembrolizumab in combination with radiotherapy with or without cisplatin after surgery, and then continued as a single agent. | Image credit: wladimir1804-stock.adobe.com
FDA Approves Perioperative Pembrolizumab in Resectable HNSCC

June 13th 2025

FDA approval-Olivier Le Moal-stock.adobe.com.jpeg
Mitomycin Intravesical Solution Gains FDA Approval for Recurrent Low-Grade NMIBC

June 12th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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September 6th 2017

ctDNA Plus Protein Biomarker Test Allows Early Detection of Pancreatic Cancer

Surabhi Dangi-Garimella, PhD
A single blood draw that combines the detection of DNA and protein markers could be more sensitive to the earlier detection of pancreatic cancer, according to a new study published in Proceedings of the National Academy of Sciences.
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September 5th 2017

Companies Continue to Face Challenges With Developing CAR-T Treatment

Surabhi Dangi-Garimella, PhD
Cellectis, a clinical-stage biotechnology company, was asked by the FDA to place a clinical hold on 2 phase 1 trials evaluating its allogeneic chimeric antigen receptor-T (CAR-T) cell treatments following the report of a fatality in the first patient treated in one of the studies.
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September 5th 2017

Mammography Device Approved by FDA Gives Patients Control Over Pressure Levels

Christina Mattina
The FDA has approved the first 2D digital mammography system that lets patients adjust the level of compression applied to their breast during the imaging procedure.
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September 4th 2017

Consistent Use of E-Cigarettes Can Help Smoking Cessation

AJMC Staff
According to a study published in The BMJ, while e-cigarettes can assist smokers to quit, the number of days of e-cigarette use will determine quit attempt and quit success.
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September 4th 2017

Healthy, but Still Hurting: Challenges of Cancer Survivorship

Laura Joszt, MA
The assumption in the United States is that once someone with cancer is cured, done with treatment, and healthy, that they are now okay. However, the reality is that survivors contend with lingering challenges that aren’t visible and make it difficult for them to ask for help or admit they need it.
Dr Kashyap Patel Discusses Implementing the Oncology Care Model
September 4th 2017

Dr Kashyap Patel Discusses Implementing the Oncology Care Model

Kashyap Patel, MD, CEO of Carolina Blood and Cancer Care, explains how previous experience with alternative payment models helped a smooth transition into the Oncology Care Model (OCM).
Podcast: This Week in Managed Care - Hurricane Relief Efforts, and Other Health News
September 3rd 2017

Podcast: This Week in Managed Care - Hurricane Relief Efforts, and Other Health News

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.
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September 1st 2017

A New Treatment Option for Newly Diagnosed AML: Gemtuzumab Ozogamicin

AJMC Staff
The treatment, which was approved nearly 2 decades ago but withdrawn due to safety and efficacy concerns, now has a new indication.
Dr Charlie Fazio on Balancing Different Delivery and Payment Models
September 1st 2017

Dr Charlie Fazio on Balancing Different Delivery and Payment Models

Charlie Fazio, MD, senior vice president and medical director of HealthPartners discusses how to balance different payment models in order to understand their impacts on cost and patient outcomes when they are implemented.
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September 1st 2017

5 Significant Developments With CAR-T Therapy

Surabhi Dangi-Garimella, PhD
A look at some of the major developments in the chimeric antigen receptor T (CAR-T) cell space.
This Week in Managed Care: September 1, 2017
September 1st 2017

This Week in Managed Care: September 1, 2017

This week, the top managed care stories included responses to the disaster in Houston after Hurricane Harvey; the approval of the first gene therapy in the United States; and a new cardiovascular indication for a popular drug to treat type 2 diabetes.
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September 1st 2017

FDA Emphasizes Risks of Pembrolizumab in Multiple Myeloma After Reviewing Halted Trials

Christina Mattina
Less than 2 months after it ordered a stop to 3 trials of pembrolizumab (Keytruda) in multiple myeloma due to safety concerns, the FDA has released a more detailed analysis of what went wrong in these trials.
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August 31st 2017

Pembrolizumab Plus Epacadostat Yields Durable Response in Advanced Melanoma: ESMO

Surabhi Dangi-Garimella, PhD
Results of a combination trial evaluating epacadostat with pembrolizumab in advanced melanoma, to be presented at the upcoming European Society for Medical Oncology (ESMO) 2017 Congress, has found that the treatment is well tolerated and has promising clinical activity.
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August 30th 2017

Race, Socioeconomic Status Linked to Rehospitalizations Among Patients With Advanced Cancer

Christina Mattina
A new study finds that individuals with advanced cancer have high rates of hospitalization in the year after diagnosis. Palliative care aimed at preventing hospital admissions may be a useful tool, especially for the populations most at risk of rehospitalization.
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August 30th 2017

FDA Approves Tisagenlecleucel, the First CAR-T Cell Therapy in the United States

Laura Joszt, MA
The FDA has approved the first chimeric antigen receptor-T (CAR-T) treatment, tisagenlecleucel (Kymriah), for the treatment of B-cell precursor acute lymphoblastic leukemia in certain pediatric and young adult patients. The therapy represents a new frontier in cancer care.
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August 29th 2017

FDA Approves Expanded Use of Fulvestrant as First-Line Hormonal Breast Cancer Therapy

Christina Mattina
AstraZeneca announced that the FDA has expanded the indications for fulvestrant (Faslodex). The drug is now approved as first-line monotherapy for women with certain types of breast cancer.
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August 28th 2017

Ancestry Determines Effective and Harmful Dose in Breast Cancer

Surabhi Dangi-Garimella, PhD
A study published in JCO Precision Oncology has identified an association between genetic inheritance and patients’ response to efficacy and toxicity in the phase 3 ECOG-ACRIN-5103 trial.
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August 25th 2017

Case Study Identifies New Trigger for CAR-T Cell Expansion in DLBCL in JCAR017 Trial

Surabhi Dangi-Garimella, PhD
Chimeric antigen receptor (CAR)-T cells can re-expand in a lymphoma patient months after the initial infusion and can also be active against the patient’s cancer, according to a new study.
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August 25th 2017

High-Dose Vitamin B Supplements Linked to Lung Cancer Risk in Men, Particularly Smokers

Christina Mattina
A new study points to an association between use of high-dose vitamin B6 and B12 supplements and an increased risk of lung cancer in men, especially in those who smoke.
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August 24th 2017

Study Finds HPV Vaccination Underutilized by Childhood Cancer Survivors

Surabhi Dangi-Garimella, PhD
A new study in the Journal of Clinical Oncology identifies an increased role for physicians in boosting human papillomavirus (HPV) vaccination rates among childhood cancer survivors to reduce their risk of a second cancer.
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August 23rd 2017

End-of-Life Palliative Care Lowered Utilization for Patients With Cancer

Christina Mattina
A new study indicates that palliative care can significantly reduce end-of-life hospitalizations and aggressive procedures among Medicare beneficiaries with advanced cancer.
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August 23rd 2017

What Is the Ideal Age for Screening Mammography?

Surabhi Dangi-Garimella, PhD
According to a new study published in Cancer, an annual screening mammogram starting at age 40 has the greatest impact on reducing mortality.
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August 21st 2017

Financial Concerns Influence Care-Seeking Behavior of Childhood Cancer Survivors

Surabhi Dangi-Garimella, PhD
High out-of-pocket (OOP) medical costs in survivors of childhood cancer can influence their treatment choices and care-related behavior, and ultimately affect their health outcomes, according to a study published in the Journal of Clinical Oncology.
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August 21st 2017

FDA Approves Besponsa for Relapsed/Refractory Acute Lymphoblastic Leukemia

Alison Rodriguez
The FDA has approved Besponsa (inotuzumab ozogamicin) for treating adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
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August 18th 2017

Phase 1 Trial Indicates Pembrolizumab Safe in Aggressive Small-Cell Lung Cancer

Christina Mattina
A small phase 1b trial of pembrolizumab in patients with small-cell lung cancer shows that the immunotherapy drug had a favorable safety profile and demonstrated “promising” antitumor activity.
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August 17th 2017

Noninvasive ctDNA Test Sensitive to Early-Stage Cancer

Surabhi Dangi-Garimella, PhD
Researchers from the United States, Netherlands, and Denmark have collaborated on developing a new liquid biopsy test that can detect circulating cell-free DNA in patients with early-stage cancer.
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August 16th 2017

Small Study Confirms Feasibility of a Personalized Neoantigen Vaccine for Melanoma

Surabhi Dangi-Garimella, PhD
A new study, published in the journal Nature, has confirmed the efficacy of a melanoma vaccine targeted against 20 predicted personal tumor neoantigens in 6 patients.
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August 16th 2017

Persistent Neuropathy After Chemotherapy Leads to Falls, Disability in Women

Christina Mattina
Following completion of their chemotherapy regimen, many women who have survived cancer experience lingering symptoms of chemotherapy-induced peripheral neuropathy, according to a new study.
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August 15th 2017

Cancer Drug Price Increases Cost Medicaid Millions in Extra Spending, Analysis Shows

Christina Mattina
An analysis by Kaiser Health News found that Medicaid incurred billions of dollars in extra spending as a result of price increases for hundreds of common drugs from 2015 to 2016, including decades-old branded drugs and generics used to treat cancer.
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August 15th 2017

Short-Term CV Risk in Patients With Newly Diagnosed Cancer

Surabhi Dangi-Garimella, PhD
A retrospective study in patients with newly diagnosed cancer has identified an increased risk of cardiovascular (CV) abnormalities that are aggravated by cancer stage.
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