Oncology

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Dordaviprone is indicated for recurrent H3 K27M-mutant diffuse midline glioma, an ultra-rare, aggressive brain tumor primarily affecting children. | Image credit: wladimir1804 - stock.adobe.com

FDA Approves Dordaviprone as First and Only Treatment for Aggressive Form of Glioma

By Rose McNulty

August 6th 2025

Dordaviprone (Modeyso) is now approved to treat recurrent H3 K27M-mutant diffuse midline glioma, an ultra-rare, aggressive brain tumor primarily affecting children.

Gen Li, PhD, MBA, president and founder of Phesi

Real-World Data, Digital Patient Profiles Are Revolutionizing Trial Design, Patient Recruitment: Gen Li, PhD, MBA

By Pearl Steinzor
Gen Li, PhD, MBA

August 4th 2025

Value-based care. | Image Credit: irissca - stock.adobe.com

Legal Navigation Services Key to Addressing Disparities in Cancer Care

By Cameron Santoro

July 31st 2025

Radiotherapy can work synergistically with immunotherapy by reprogramming the tumor microenvironment. | Image credit: Crystallight-stock.adobe.com

Brain Radiotherapy Plus ICIs Boost Survival in SCLC With Brain Metastases

By Jared Kaltwasser

July 30th 2025

As SCLC continues to pose a therapeutic challenge due to rapid progression and early metastasis, the convergence of immunotherapy and precision radiation holds promise to extend survival and improve outcomes. | Image credit: mi_viri - stock.adobe.com

Chemoimmunotherapy Shows Promise for Limited-Stage SCLC in Real-World Study

By AJMC Contributor

July 29th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

Continuing Medical Education

August 11th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology

August 11th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

December 23rd 2015

Rivaroxaban Safe and Effective in Cancer Patients With Thrombosis

Laura Joszt, MA

Although rivaroxaban was approved by the FDA in 2012, there has remained a knowledge gap about how it works with cancer patients. A recent study found that the therapy is safe and effective when used among patients with cancer.

December 22nd 2015

OB-GYN Groups Say Insurers' Genetic Testing Rules Limit Access to Care

Mary K. Caffrey

The statement from the obstetricians and gynecologists said that there aren't enough certified genetic counselors to meet demand. In a statement, the groups said this will limit access to care if patients must wait for assistance before ordering tests.

December 22nd 2015

Top 10 Articles from Evidence-Based Oncology for the Year 2015

Surabhi Dangi-Garimella, PhD

The most read articles in The American Journal of Managed Care's Evidence-Based Oncology ranged from personal narratives to healthcare policy issues that impact the broader population.

This Week in Managed Care: December 19, 2015

December 19th 2015

This Week in Managed Care: December 19, 2015

This week in managed care, Martin Shkreli, CEO of Turing Pharmaceuticals was arrested on charges of fraud; new research find that drug costs continue to take up a larger share of healthcare spending; and 3 healthcare experts take a look at how to fix the 340B drug pricing program.

December 18th 2015

Merck's Pembrolizumab Receives Approval for Expanded Indications

Pembrolizumab has been approved as first-line treatment for patients with unresectable or metastatic melanoma.

December 18th 2015

What We're Reading: Taxpayers Spending Millions on Expensive Generic Drugs

What we're reading, December 18, 2015: HHS report finds generic drug prices rising faster than inflation; UnitedHealthcare's real-time drug approval tool; and government overcharged by private Medicare Advantage plans.

December 18th 2015

Progress Toward Healthy People 2020: CDC Report Claims Reduction in Cancer Incidence

Surabhi Dangi-Garimella, PhD

Results of an analysis of 2012 cancer incidence and survival from various cancer registries, published in CDC's Morbidity and Mortality Weekly Report, indicates reduced incidence of overall cancer across the United States.

December 18th 2015

FDA Seeks Nationwide Ban on Letting Minors Use Tanning Beds

Mary K. Caffrey

Eleven states already ban minors from using tanning beds, and most states have other restrictions such as requiring a parent's permission.

December 17th 2015

Report Provides an Update on the 340B Drug Pricing Program

Surabhi Dangi-Garimella, PhD

A new report by the Berkeley Research Group provides numbers on Medicare Part B spending by 340B entities, especially for oncology drugs.

December 17th 2015

Need to Lower Drug Costs, Not the Size of the Donut Hole, for Medicare Beneficiaries With Cancer

Surabhi Dangi-Garimella, PhD

A study in the Journal of Clinical Oncology predicts financial stress on Medicare Part D beneficiaries on oral anticancer medicines, even after the expected closing of the donut hole in 2020.

December 16th 2015

Kadcyla and Opdivo Too Expensive for NICE

NICE rejects promising oncology agents once again, citing high drug cost.

December 16th 2015

FDA Updates: Oncology

Surabhi Dangi-Garimella, PhD

Several new FDA approvals and research advances in oncology have the potential for improved outcomes among cancer patients.

December 16th 2015

Managed Care Updates: Oncology

Surabhi Dangi-Garimella, PhD

Updates on screening age recommendations for mammograms, CDC report on a decline in smoking rates in the country, and regulation of laboratory-developed tests.

Dr Michael Kolodziej Outlines Ways to Reform 340B

December 15th 2015

Dr Michael Kolodziej Outlines Ways to Reform 340B

There are 3 potential solutions for reforming the 340B drug pricing program, according to Michael Kolodziej, MD, national medical director of oncology solutions in the Office of the Chief Medical Officer at Aetna.

December 15th 2015

Choosing Wisely: Eliminating Unnecessary Biopsies

Surabhi Dangi-Garimella, PhD

A retrospective analysis of phase 1 oncology studies that used biopsy-derived pharmacodynamic biomarkers, could not draw a correlation between subsequent drug development and biopsy sample collection.

December 15th 2015

The Struggle Between Oncology Care Cost and Value

Joseph Alvarnas, MD

While cost is an important component of value, it tells only a small part of the cancer care story. By focusing on issues of payment and cost alone, we miss our opportunity to engage cancer care stakeholders in the process of creating a more effective system of care.

December 15th 2015

Patient Access to Oncology Care in ACA Exchange Plans

Caroline F. Pearson Deirdre B. Parsons, MPP, MPH, MS

This article describes provider networks and benefit design-including deductibles, cost-sharing, and maximum out-of-pocket limits-for oncology care in 2015 health insurance exchanges.

December 15th 2015

Healthcare Leaders Offer Solutions for Reforming 340B in New Issue of Evidence-Based Oncology

Depending on one's point of view, the 340B prescription drug program keeps safety net hospitals afloat or serves as a profit center at the expensive of community providers. Three leading voices-Rena M. Conti, PhD; Peter B. Bach, MD, MAPP; and Michael Kolodziej, MD; recommend reforms in the new issue of Evidence-Based Oncology, a publication of The American Journal of Managed Care.

December 15th 2015

PrecisionFDA Launched With Promise of Transparency and Quality Care

Surabhi Dangi-Garimella, PhD

The FDA, today, launched precisionFDA, a cloud-based platform that members can utilize to access and share data sets, analysis pipelines, and bioinformatics tools.

December 15th 2015

ACCC ICLIO meeting

Surabhi Dangi-Garimella, PhD

At the first annual conference of the Institute for Clinical Immuno-Oncology on October 1, 2015, in Philadelphia, the discussion revolved around integrating immuno-oncology into clinical practice and programs that assist with patient access to these treatments.

December 15th 2015

COA Payer Summit

Surabhi Dangi-Garimella, PhD

Providers and payers came together to discuss challenges and share success stories as they adapt to the changing healthcare realm.

December 14th 2015

Measuring Financial Toxicity in Cancer Patients

Pauline Lee, PharmD Jonas A. de Souza, MD

With the rising costs of cancer care, evidence-based tools can help physicians screen patients for financial toxicity.

December 14th 2015

Eliminating a Barrier to Cancer Care through Universal Fair Access to Oral Chemotherapy Medications

Christopher Hansen

The advocacy affiliate of the American Cancer Society, the American Cancer Society Cancer Action Network, is working across the country to pass and implement strong oral chemotherapy fairness laws to help ensure cancer patients have access to the recommended course of treatment without added out-of-pocket costs based on how their drug is administered.

December 14th 2015

The Financial Impact of Cancer Care: Implications and Potential Solutions

Veena Shankaran, MD, MS

Addressing the financial burden of cancer treatment requires efforts at the policy, payer, and clinic level, and implementation of these strategies, in clinical practice, requires commitment from various stakeholders.

December 14th 2015

Impact of Oral Parity: A Personal Story

Christopher Hansen

Oral chemotherapy ensured improved quality of life for a young, stage 3 pancreatic cancer patient.

December 14th 2015

Healthcare Transparency in Need of Academic Vigilance

Surabhi Dangi-Garimella, PhD

A report by STAT has found that a majority of institutions conducting clinical trials fail to report their results to the website ClinicalTrials.gov.

December 14th 2015

What We Need to Know About Bladder Cancer and Its Treatment

There is, currently, an unmet need in bladder cancer, a disease expected to be responsible for 16,000 deaths in 2015.

December 14th 2015

What We're Reading: Public Health Initiatives Are Underfunded in the US

What we're reading, December 14, 2015: public health initiatives are underfunded despite being a big return on investment; the FDA repeatedly approved the cancer drug Afinitor without proof it extended life; and a nurse may have exposed patients in a maternity wing to tuberculosis.

Dr Stacey W. McCullough Discusses High-Cost Therapies and Me-Too Drugs

December 13th 2015

Dr Stacey W. McCullough Discusses High-Cost Therapies and Me-Too Drugs

Stacey W. McCullough, PharmD, senior vice president of pharmacy at Tennessee Oncology, discussed strategies for managing high-cost treatments, the impact of me-too drugs, and how clinical pathways can help physicians make treatment decisions at the point of care.

This Week in Managed Care: December 12, 2015

December 12th 2015

This Week in Managed Care: December 12, 2015

This week in managed care, an analysis found the penalty for being uninsured will exceed the cost of insurance for most Americans in 2016, thousands met for the annual meeting of the American Society of Hematology, and Horizon Blue Cross Blue Shield's OMNIA plan gets good news and bad news in New Jersey.

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