Oncology

Kyprolis failed to improve survival in the phase 3 FOCUS trial in patients who had relapse following at least 3 prior regimens.

Scientists at Hopkins are working on developing a test that can rapidly sequence cellular DNA in a blood sample for early diagnosis of cancer, which could have a tremendous potential in asymptomatic subtypes of the disease.

CMS provided COA a draft of an episode-based payment model being developed at their Innovation Center. COA has been in collaboration with CMS on developing this model.

The gene, normally expressed only in a developing embryo, was found expressed in several different childhood cancers.

With the aim to authenticate and regulate medical information, Cancer Research UK plans to provide the most up-to-date and accurate healthcare information.

Cologuard had received recommendation for premarket approval from a FDA advisory panel back in March.

The study, published in the Journal of Clinical Oncology, examined national statistics for the period between 2007 to 2010 for people aged 18-64 of age.

Using the genome editing tool known as CRISPR, researchers were able to selectively silence two genes in HPV that are responsible for the growth and survival of cervical carcinoma cells.

The approval follows results from the RETRIEVE trial, conducted in patients who had previously responded to Velcade but had relapsed.

Although the overall rate of NSCLC is lower, certain subtypes of the disease fared better than others, the study published in the journal Cancer found.

New research found that the risk of developing breast cancer increased in women who had mutations of a gene related to BRCA2, the PALB2 gene.

The research, published in the journal Cell, proposes revising treatment based on the molecular constitution of the tumor when it presents itself, rather than the tissue or organ of origin.

According to Sir Andrew Dillon, chief executive of NICE, the high price that Roche is demanding for Kadcyla is beyond the means of NHS to cover.

The study, published in NEJM, proposes enhanced surveillance in women with PALB2 mutations, similar to women harboring BRCA2 mutations.

High rate of hospice survivors, especially in Alabama and Mississippi, have raised doubts about improper practices.

Published in Nature Communications, the study identified a new gene fusion and rearrangement of the estrogen receptor, responsible for the aggressive nature of luminal B breast cancer.

The Lancet study, conducted in Europe, found a survival benefit with early diagnosis, but does not agree that the benefit outweighs some of the associated risks of the test.

The results of ruxolitinib's RESPONSE trial were recently presented at ASCO's annual meeting.

Amy Berman, BS, RN, senior program officer at the John A. Hartford Foundation, says that the triple aim promotes better health, better care, and lower costs. All too often, however, current oncology treatment regimens do not achieve the triple aim.

Within a week of Sandoz applying for approval of it's biosimlar to Amgen's Neupogen, U.S. senators want the FDA to lay down guidelines on naming these drugs.

The study evaluated carfilzomib in combination with Celgene's lenalidomide and dexamethasone.

ABT-414 is being developed to treat glioblastoma multiforme.

Today, the U.S. Food and Drug Administration took important steps to ensure that certain tests used by health care professionals to help diagnose and treat patients provide accurate, consistent and reliable results.

The study, published in the journal Cell, was conducted at the Whitehead Institute of Biomedical Research.