Oncology

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Microscopic view of non small cell lung cancer cells. Image Credit: © Keopaserth - stock.adobe.com

From Amivantamab to Next-Generation Therapies: The Evolving Bispecific Antibody Landscape in NSCLC

By Alana Hippensteele, MA

September 6th 2025

Bispecific antibodies are emerging as a transformative class in advanced non–small cell lung cancer (NSCLC), with agents such as amivantamab and zenocutuzumab already demonstrating clinical benefit and a broad pipeline of investigational therapies showing promise in overcoming resistance.

Lung cancer. Image Credit: © Dr Microbe - stock.adobe.com

Comparing Global Standards in Lung Cancer: NCCN, ESMO, and CHEST Guidelines

By Alana Hippensteele, MA

September 6th 2025

Most of the patients who experienced superior outcomes with atezolizumab and chemotherapy had higher levels of NOTCH1 expression. | Image credit: Pixel-Shot - stock.adobe.com

NOTCH1 Levels Impact Immune Response in SCLC

By Jared Kaltwasser

September 2nd 2025

The findings can help guide ongoing and future clinical trials to help solve remaining challenges in LS-SCLC. | Image credit: Jennifer - stock.adobe

Neoadjuvant Immunotherapy Plus Chemotherapy Shows Promise in LS-SCLC

By Jared Kaltwasser

August 31st 2025

PD-1 blockade has previously shown success in a first-line setting in ES-SCLC, and nab-paclitaxel is albumin-bound and solvent-free, which the investigators explained may minimize the toxicity associated with paclitaxel therapy. | Image credit: didesign - stock.adobe.com

Camrelizumab Plus Carboplatin, Nab-Paclitaxel Shows Efficacy in ES-SCLC

By Jared Kaltwasser

August 29th 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

Continuing Medical Education

September 7th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology

September 7th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

More News

Dr Lawrence Shulman Discusses Pathways and Improvements in Breast Cancer Treatment

December 8th 2018

Dr Lawrence Shulman Discusses Pathways and Improvements in Breast Cancer Treatment

Improvements in treatments have led to less toxicities and better quality of life for patients with breast cancer, said Lawrence N. Shulman, MD, director of the Center for Global Cancer Medicine at the Abramson Cancer Center, and professor of Medicine at the Hospital of the University of Pennsylvania.

December 7th 2018

The Future of Cancer Care

Joseph Alvarnas, MD

Joseph Alvarnas, MD, discusses the history of cancer care and what the future might look like in the space.

December 7th 2018

Renting Health vs Buying Cures: How New Financing Tools Can Boost Cancer Therapy Development

Evidence-Based OncologyTM sat down with Andrew W. Lo, PhD, to discuss his proposals to increase investment in medical innovation and utilization by giving investors more ways to support both research organizations and individual patients.

December 7th 2018

Increasing Rates of Cancer Screening

John B. Kisiel, MD

John B. Kisiel, MD, and Philip Parks, MD, MPH, provide an update on the future of cancer screenings and explain how improved treatment regimens offer the potential to reduce the cancer-related healthcare cost burden.

Beth Wittmer on Keeping Patients With Neutropenia Out of the Emergency Department

December 7th 2018

Beth Wittmer on Keeping Patients With Neutropenia Out of the Emergency Department

Informing patients about what to look for with neutropenia can help keep them out of the emergency department (ED) so they can be treated in the clinic, instead, said Beth Wittmer, RN, OCN, manager of care management at Florida Cancer Specialists and Research Institute.

Dr Sibel Blau Outlines Changes to Her Practice to Prepare for OCM

December 6th 2018

Dr Sibel Blau Outlines Changes to Her Practice to Prepare for OCM

Years before the Oncology Care Model (OCM) was implemented, Northwest Medical Specialties started preparing by making changes to the personnel in the practice, explained Sibel Blau, MD, medical oncologist at Northwest Medical Specialties, PLLC.

Dr Thorvardur Halfdanarson Discusses Lack of Risk Factors, Biomarkers in NETs

December 4th 2018

Dr Thorvardur Halfdanarson Discusses Lack of Risk Factors, Biomarkers in NETs

There is a lot of disagreement, even within the neuroendocrine tumor (NET) circles, that there are biomarkers that predict outcomes and some that may even predict responses to therapy, explained Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic.

November 30th 2018

CDC Data: Life Expectancy Decreases as Deaths From Suicide, Drug Overdose Increase

Laura Joszt, MA

New reports from the CDC have highlighted troubling increasing trends in suicides and drug overdose rates as life expectancy in the United States declined.

Cancer Therapy's Impact on Cognitive Function May Be Due to Accelerated Aging

November 28th 2018

Cancer Therapy's Impact on Cognitive Function May Be Due to Accelerated Aging

A study published this week suggests that some anticancer treatments speed up the biological aging process, and this aging effect could be linked to the cognitive decline experienced by patients undergoing cancer treatment.

Podcast: This Week in Managed Care—Addressing Social Needs Impacting Health and Other Health News

November 24th 2018

Podcast: This Week in Managed Care—Addressing Social Needs Impacting Health and Other Health News

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

This Week in Managed Care: November 23, 2018

November 23rd 2018

This Week in Managed Care: November 23, 2018

This week, the top managed care news included HHS Secretary Alex Azar hinting that the government may get more involved in addressing social needs impacting health; work rules in Arkansas cost thousands their Medicaid coverage; research finds a shorter course of hepatitis C treatment may be just as effective as the full course of treatment.

Beth Wittmer on Educating Patients on Neutropenia as a Side of Effect of Cancer Treatment

November 22nd 2018

Beth Wittmer on Educating Patients on Neutropenia as a Side of Effect of Cancer Treatment

As patients start chemotherapy to treat their cancer, they are educated on the side effects, particularly neutropenia, said Beth Wittmer, RN, OCN, manager of care management at Florida Cancer Specialists and Research Institute.

Dr Thorvardur Halfdanarson: Access Is a Big Management Challenge in NETs

November 20th 2018

Dr Thorvardur Halfdanarson: Access Is a Big Management Challenge in NETs

Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic, outlines the biggest management challenges in neuroendocrine tumors (NETs).

November 17th 2018

AMA's McAneny Calls for Real-time Oncology Payment Model Led by Physicians

In the keynote address at Patient-Centered Oncology Care® 2018, Barbara McAneny, MD, a New Mexico oncologist/hematologist and the current president of the American Medical Association (AMA), shared her diagnosis for the current crisis in US healthcare, as well as a prescription—a new real-time oncology payment model led by physicians.

Dr Brian Koffman Highlights the Benefits and Risks of CAR T Therapy

November 17th 2018

Dr Brian Koffman Highlights the Benefits and Risks of CAR T Therapy

Since chimeric antigen receptor (CAR) T-cell therapy is still in early development there are benefits and risks that eligible patients will have to weigh, including the durable response against the limited amount of data and toxic side effects, said Brian Koffman, MDCM, DCFP, DABFM, MS Ed, medical director, CLL Society.

FDA Gives Speedy Approval to Brentuximab for Peripheral T-Cell Lymphoma

November 17th 2018

FDA Gives Speedy Approval to Brentuximab for Peripheral T-Cell Lymphoma

Allison Inserro

The FDA announced Friday it expanded the approved use of brentuximab vedotin (Adcetris) in combination with chemotherapy for adult patients with certain types of peripheral T-cell lymphoma, using a new review process designed to increase efficiency.

Nivolumab Plus Azacitidine Increased Response Rates in Patients With Relapsed AML

November 16th 2018

Nivolumab Plus Azacitidine Increased Response Rates in Patients With Relapsed AML

David Bai, PharmD

The addition of nivolumab to azacitidine led to significantly better overall response rate and overall survival compared with previous hypomethylating agent-based regimens in patients with relapsed acute myeloid leukemia (AML), according to the results of a recent phase 2 study.

November 16th 2018

Keeping Ahead of the Curve in the Transition to Oncology Value-Based Payment

Christina Mattina

At a session of The American Journal of Managed Care®'s Patient-Centered Oncology Care® 2018 meeting, held November 16 in Philadelphia, panelists shared their views on the future of oncology value-based payment models and how they as payers and providers can help advance these models.

Dr Marcus Neubauer Discusses the Evolution of Care Teams in Oncology

November 16th 2018

Dr Marcus Neubauer Discusses the Evolution of Care Teams in Oncology

As practices shift to value-based care, they need truly coordinated care teams that discuss high-risk patients and identify ways to deliver care to them, said Marcus Neubauer, MD, chief medical officer, US Oncology.

The New Oncology Bundle Model: What We Know and Don't Know

November 15th 2018

The New Oncology Bundle Model: What We Know and Don't Know

CMS' announcement of a new mandatory oncology bundled payment model wasn't a surprise. It reinforces CMS' continued commitment to creating innovative ways of transforming care.

November 14th 2018

Erich Mounce Joins OneOncology as Chief Operating Officer

Former chief exeutive officer of the West Cancer Center brings over 3 decades of technology, operations, and care advancement to the OneOncology National Network.

Cancer Surpasses CVD as Leading Cause of Death in High-Income Counties

November 14th 2018

Cancer Surpasses CVD as Leading Cause of Death in High-Income Counties

Jaime Rosenberg

As a result of increased prevention and improved medical treatment of cardiovascular disease (CVD), and despite increasing rates of obesity and diabetes, cancer has gradually surpassed CVD as the leading cause of death in high-income counties. However, CVD is more likely to be the leading cause of death in low-income counties.

Cost Burden for Patients With Blood Cancers Eclipses the Burden in Other Cancers

November 13th 2018

Cost Burden for Patients With Blood Cancers Eclipses the Burden in Other Cancers

Laura Joszt, MA

Patients with blood cancers are burdened with higher costs than patients with other cancers, and spending in blood cancers does not return to precancer levels, according to a new study from the Leukemia & Lymphoma Society.

Nobel Prize Winner Dr James Allison on the Impact His Work Has Made

November 12th 2018

Nobel Prize Winner Dr James Allison on the Impact His Work Has Made

It has been good knowing that treatments he has had a hand in developing will give years of quality life to patients, where treatments only gave a few months before, explained James Allison, PhD, chair of the Department of Immunology, the Vivian L. Smith Distinguished Chair in Immunology, director of the Parker Institute for Cancer Research, executive director of the Immunotherapy Platform at MD Anderson Cancer Center, and 2018 Nobel Prize cowinner in Medicine.

November 9th 2018

Hospital Cancer Pain Management by Electronic Health Record–Based Automatic Screening

Jinyoung Shin, MD, PhD Hyeonyoung Ko, MD, MPH Jeong Ah Kim, BS Yun-Mi Song, MD, PhD Jin Seok Ahn, MD, PhD Seok Jin Nam, MD, PhD Jungkwon Lee, MD, PhD

A cancer pain control program for inpatients based on electronic health record–based automatic screening provided effective pain relief and achieved high satisfaction among patients and physicians.

Azar Announces Mandatory Oncology Payment Model Is Coming

November 8th 2018

Azar Announces Mandatory Oncology Payment Model Is Coming

Mary Caffrey Allison Inserro

The announcement is an about-face from earlier efforts that scrapped a cardiac care bundled payment program originally developed during the Obama administration.

Dr Thorvardur Halfdanarson on Diagnostics in NETs

November 8th 2018

Dr Thorvardur Halfdanarson on Diagnostics in NETs

Thorvardur Halfdanarson, MD, associate professor of medicine and consultant in medical oncology, Mayo Clinic, discusses improvements in diagnostics for neuroendocrine tumors, as well as what improvements are still needed.

Immunotherapy Improves Survival in Metastatic Melanoma

November 7th 2018

Immunotherapy Improves Survival in Metastatic Melanoma

David Bai, PharmD

The use of CTLA-4, PD-1, or a combination approach achieved high response rates and improved overall survival in patients with CDKN2A mutations with metastatic melanoma, based on the results of a study by Helgadottir et al.

$Early Access to Daratumumab Confirms Safety in Relapsed/Refractory Multiple Myeloma$

November 7th 2018

Early Access to Daratumumab Confirms Safety in Relapsed/Refractory Multiple Myeloma

Laura Joszt, MA

Daratumumab, a human CD38-directed monoclonal antibody, has been confirmed as safe in a population of heavily pretreated patients with multiple myeloma who received access to the treatment before the medication was commercially available, according to an early access treatment protocol study published in Cancer.

Hispanics Living With HIV at Increased Risk of HPV-Related Cancers

November 6th 2018

Hispanics Living With HIV at Increased Risk of HPV-Related Cancers

Jaime Rosenberg

Hispanics living with HIV are at an increased risk of developing cancers caused by the human papillomavirus (HPV) compared to the general Hispanic population, and among people living with HIV, Hispanics are more likely to be diagnosed with cervical and penile cancer.

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