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Two doses of the Moderna COVID-19 vaccine have reduced efficacy against the Omicron variant; a federal appeals court reinstates the Biden administration’s health care worker vaccine mandate in 26 states; a new combination therapy may reduce breast cancer progression.

Pulmonary arterial hypertension is a rare form of pulmonary hypertension that poses diagnostic challenges and often comes with a delayed diagnosis.

Subcutaneous (sub-Q) administration of isatuximab plus pomalidomide may provide survival advantages for patients with relapsed and refractory multiple myeloma, making it another treatment option for this patient group.

Investigators said pathologic complete response was higher with a molecularly selected subgroup of patients with early-stage breast cancer treated with a nonchemotherapy combination that included a trastuzumab biosimilar.

Results of a secondary analysis indicate anxiety, depression, physical quality of life (QOL), and sexual function in obese infertile woman with polycystic ovary syndrome (PCOS) seem to be more related to obesity rather than PCOS status.

In India, incidence of the deadly fungal infection grew throughout 2021, while supply chain shortages inhibited optimal treatment for each patient.

Patients with comorbid nonalcoholic fatty liver disease (NAFLD) and chronic plaque psoriasis were shown to have significantly lower estimated glomerular filtration rate levels and greater prevalence of more advanced chronic kidney disease.

The Omicron variant may cause a wave of infections as soon as January 2022; Pfizer’s COVID-19 pill, Paxlovid, was found to reduce the risk of hospitalization and death by 88%; JPMorgan Health Care Conference will move to a virtual format after receiving pressure from major drug companies.

Patients with obstructive sleep apnea (OSA) exhibited similarly improved insomnia and quality-of-life outcomes when administered hypoglossal nerve stimulation (HNS) vs standard-of-care positive airway pressure (PAP) therapy.

With a low number of approved medications for pediatric plaque psoriasis, secukinumab is a valuable new addition to the limited treatment options available.

Megan Olsen, MPH, principal at Avalere, discusses how the impact of small patient populations and other limitations may influence payer conversations about gene and cell therapies.

Researchers recommend vaccination against COVID-19 for patients with multiple sclerosis (MS) after confirming that several types of vaccines are safe and produced no significant adverse events.

An abstract presented at the 63rd Annual American Society of Hematology Annual Meeting and Exposition shows that although daratumumab use in multiple myeloma holds great promise, challenges remain in the use of clinical pathways for treatment direction with the monoclonal antibody—which the investigators say may also present opportunities for change.

Women with systemic lupus erythematosus (SLE) were twice as likely to experience carotid plaque buildup during the 5 years of this study.

Next Gen ACO recently re-branded as the Value Based Care Coalition. To learn more about the organization's new phase, we spoke with executive director Mara McDermott.

In a new review article, investigators outline the challenges to studying the disease, but also point to big data as an important tool moving forward.

John Burke, MD, hematologist, Rocky Mountain Cancer Centers, discussed findings of the late-breaking abstract session POLARIX presented at ASH 2021, which compared pola-R-CHP with standard-of-care R-CHOP in patients with previously untreated DLBCL.

More Americans reported skipping medical care over cost concerns; today marks the 1-year anniversary of the COVID-19 vaccine rollout; hospitals in Minnesota are overwhelmed with COVID-19 patients.

Results presented at the 63rd Annual American Society of Hematology Meeting showed that using polatuzumab vedotin instead of vincristine in R-CHOP improved progression-free survival in patients with newly diagnosed diffuse large B-cell lymphoma.

David Yeomans, PhD, associate professor of anesthesiology, perioperative, and pain medicine at Stanford University School of Medicine, outlines potential mechanisms underlying menstrual-related migraine.

Recent surveys shed light on oncologist and patient perceptions of the switch to biosimilars and patient mental health.

Frederick Locke, MD, vice chair, Department of Blood and Marrow Transplant and Cellular Immunotherapy Program, co-leader, Immuno-Oncology, Moffitt Cancer Center, discusses findings of the phase 3 ZUMA-7 trial presented at ASH 2021 and how use of axicabtagene ciloleucel can be optimally applied in a real-world setting.

Patients who have experienced acute kidney injury (AKI) reported experiencing significant impacts on aspects of their physical and emotional health, demonstrating the different ways that AKI episodes influence patients’ health-related quality of life.

Sattva S. Neelapu, MD, professor and deputy department chair in the Department of Lymphoma/Myeloma in the Division of Cancer Medicine at the University of Texas MD Anderson Cancer Center, discusses findings of the ZUMA-12 study examining axicabtagene ciloleucel (axi-cel) as a first-line treatment option for high-risk patients with large B-cell lymphoma.

Leon Herndon Jr, MD, a glaucoma specialist, ophthalmologist, and professor of ophthalmology at the Duke University Eye Center, explains certain considerations ophthalmologists may need to take into account when treating older patients and the need for more specialists to meet clinical demand.

Two-third of those who receive a chronic lymphocytic leukemia (CLL) diagnosis are age 65 or older, so the ease with which drugs are covered in Medicare has an outsized role in patient access to care.

Two posters presented at The Liver Meeting identified the primary care coordinators for patients with nonalcoholic steatohepatitis (NASH) and areas of unmet need among specialists to provide optimal management.