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Although the FDA has approved 599 orphan drugs since 1983, patent laws and other exclusivities keep most from any competition.

An ongoing multicenter study in Japan will evaluate reductions in pulmonary vascular resistance 8 months after initiating the combination therapy in pulmonary arterial hypertension.

Exposure to nitrogen dioxide (NO2), an air pollutant generated from automobiles, may increase risk of mortality, even if the exposure amount is well below regulatory limits, investigators concluded.

There is no consistent evidence showing clear benefit of various nutritional factors on the risk of atopic dermatitis.

Conducting a review of data published over a 25-year period, researchers highlight the importance of this type of research they say offers insight that drives the success of SMA treatment.

The bipartisan bill spells out 5 step therapy exemptions for patients by amending the Employee Retirement Income Security Act of 1974.

As the first quarter of 2021 ends, patients choosing to keep using secukinumab may be offered an inducement to switch to another biologic, ixekizumab.

Hinge Health’s State of MSK Report 2021 found that although patient outcomes remained stagnant in the past decade, cost for musculoskeletal care doubled with services provided in emergency rooms and outpatient/inpatient facilities associated with significantly increased spend.

Investigators aimed to close the knowledge gap on interindividual variability in cognitive evaluation outcomes by considering both cognitive impairment and mood disorders to better prediction accuracy.

How are researchers leveraging what is currently known about the pathogenesis and progression of Parkinson disease into the development of potential novel therapies, and what role should neurologists and patients play in addressing this neurodegenerative condition?

A substantially higher risk of anal carcinoma following the development of anogenital warts was seen among adults living with HIV and being treated in Washington, DC.

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

President Biden outlines new vaccine goal; the United States will stop distributing Eli Lilly's bamlanivimab; rates of human papillomavirus (HPV) decrease among females.

This week, the top managed care news included efficacy data on AstraZeneca’s COVID-19 vaccine questioned; coverage from the NCCN 2021 Virtual Annual Conference; COVID-19 poses risks to children with poorly controlled type 1 diabetes.

A Swedish study analyzed 5 years’ worth of data from over 3000 patients, 40% of whom received a molecular diagnosis.

Largely driven by hospitalizations and medications, health care costs were found to be 3 times greater for patients with chronic obstructive pulmonary disease (COPD) than for healthy individuals, according to a recent Danish study.

The announcement allowing the administration of COVID-19 vaccines in dialysis centers is part of a larger $10 billion investment, largely funded by the American Rescue Plan, to expand access.

In part 2 of the COPD Stakeholder Summit, a panel of experts discuss personalized approaches to COPD management and treatment efficacy.

Machine learning models can help predict which children diagnosed with childhood asthma before age 5 will continue to experience symptoms as they get older.

Survey responses of 320 US hospitals highlight the dire consequences of the COVID-19 pandemic on facilities and point to a future of ongoing financial and staffing challenges.

Among health care workers, disrupted sleep and daily burnout were associated with a greater risk of developing COVID-19, as well as having more severe symptoms and a longer recovery period.

This case study, involving a boy aged 13 years, shows that in a little over 1 year, the treatment yielded significant clinical benefit.

After a 12-month follow-up of patients in the CHAMP-HF registry, Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS) was shown to be more prognostically accurate compared with New York Heart Association functional class.

AstraZeneca releases updated efficacy data for its COVID-19 vaccine following scrutiny; Rachel Levine, MD, is confirmed as the first openly transgender person to serve in a federal position; hundreds of migrant children remain in isolation after testing positive for COVID-19.

Twice weekly high doses of carfilzomib in combination with lenalidomide and dexamethasone was tolerable and effective among patients with newly diagnosed multiple myeloma.

More than two-thirds of patients with chronic lymphocytic leukemia (CLL) survived at least 2 years but were highly susceptible to adverse events (AEs), in a recent study.

Reviewing available literature on the implications of oral health in people with Parkinson disease, researchers found reduced rates of oral hygiene and high prevalence of mostly preventable oral conditions, such as tooth decay and receding gums.