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While the results are early, if further research proves the approach effective, it could help boost the impact of treatments like chimeric antigen receptor (CAR) T-cell therapy, which to date hasn’t had much luck in solid tumors.

Diabetic retinopathy costs the United States $6.2 billion a year. Better screening techniques that can catch neurodegeneration at earlier stages have the potential to cut costs and improve quality of life for patients.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Patients with multiple myeloma (MM) who had disease progression on multiple therapies may benefit from treatment with the oral therapies selinexor and dexamethasone.

Maine wants to take more control over its Affordable Care Act marketplace; Surgeon General Jerome Adams, MD, MPH, has issued an advisory against marijuana use in young people and pregnant people; the FDA is warning of rare occurrences of serious liver injury from use of 3 hepatitis C virus (HCV) drugs.

This week, the top managed care stories included a huge ruling against one opioid maker and a settlement offer from another; an expert panel calling for broader screening for hepatitis C; a review showing there are more fatal events linked to a multiple sclerosis drug than previously known.

Postmenopausal women who undergo 5 years of menopausal hormone therapy, starting at age 50, showed a significant increase in breast cancer incidence, and can remain at risk for more than a decade.

The National Psoriasis Foundation is working to get laws to curb to step therapy practices at the state level.

The researchers, who used autopsy reports of 252 people who died of AIDS in New York City between 1984 and 2016, found that infections associated with the virus are still the leading cause of death for the patient population in the state.

Using a body-worn sensor to detect falls at home is feasible for elderly individuals, including those with Parkinson disease, who have a higher risk of falling, according to new study findings.

A new government analysis revealed that despite a previous warning, CMS failed to take steps to ensure that Medicare Part D does not also pay for drugs that should be covered under the Part A hospice benefit; with studies of antidepressants’ safety and efficacy only following patients for a few years and with more people taking antidepressants for longer periods of time, health professionals are concerned that some people taking the drugs for extended periods shouldn’t be and are thus subjecting themselves to side effects and potential health risks; Medicaid advocates in Nebraska have filed a lawsuit to try and force the state to implement Medicaid expansion no later than November 17, 2019.

Here are 5 interesting findings from the August 2019 issue of AJMC®.

The authors said their finding that preventive medications for migraine might be underutilized surprised them, given that guidelines for migraine prevention exist in the United States, Canada, and Europe.

Coverage from the July 11, 2019, meeting of the Institute for Value-Based Medicine®, an initiative of The American Journal of Managed Care®. The meeting took place in Arlington, Virginia.

Researchers identified a new gene mutation that impacts an individual’s sleep necessity and wakefulness.

Purdue Pharma is offering up to $12 billion to settle lawsuits over its role in the opioid epidemic; the US Preventive Services Task Force is aiming to expand its hepatitis C virus (HCV) screening recommendations to include all adults aged 18 to 79 years; the majority of Democratic voters would be more likely to support a candidate that backs a single-payer health system like Medicare for All.

Dapagliflozin’s fast track designation follows findings from last year’s DECLARE-TIMI trial, a cardiovascular outcomes trial that showed the drug’s significant impact on delaying the loss of kidney function and reducing hospitalization risk for heart failure.

New and effective antibiotics are rarely prescribed in carbapenem-resistant Enterobacteriaceae (CRE) infections, which are a family of the most drug-resistant bacteria.

Other than surgery and medications, including opioids, there are few options for treating pain symptoms, which affect more than half of all patients with neurofibromatosis type 1.

Johnson & Johnson is ordered to pay $572 million for its role in Oklahoma's opioid epidemic; President Trump eliminates protection of sick immigrants to remain in the United States; a federal judge is expected to rule on the Missouri law banning abortion after 8 weeks today.

Even as more competition entered the market, the prices of self-administered disease-modifying therapies for multiple sclerosis (MS) rose steadily from 2006 to 2016, and seniors with Medicare Part D coverage saw a 7.2-fold increase in out-of-pocket costs.

A case report of a 35-year-old woman with chronic migraine who had a 2-year history of severe pain that did not improve with medical therapy showed that peripheral nerve field stimulation could safely treat chronic migraine.

Using 2 decades' worth of data, researchers were able to identify disparities in HIV outcomes across more than 25,000 people living with HIV in Tennessee.

Among more than 10,000 women breast cancer survivors aged 65 years or older who started adjuvant endocrine therapy, those who had a mental health comorbidity were 33% more likely to use opioids.

Results of a subgroup analysis within a randomized, controlled trial show that the monoclonal antibody dupilumab (Dupixent) improved clinical and patient-reported outcomes among patients with chronic rhinosinusitis (CRS) with nasal polyps and comorbid asthma.

The price for Otezla is higher than many analysts expected.

The findings suggest that a commonly used diabetes therapy, metformin, could be used to target specific proteins that trigger DNA repair.

Quitting smoking can reduce a heavy smoker’s risk of heart disease within 5 years.