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FDA's approval of entrectinib for neurotrophic tyrosine receptor kinase (NTRK) fusion-positive tumors represents a new paradigm in cancer treatment; It treats a cancer based on a common biomarker seen across different tumors rather than based on the location in the body where the cancer originated. The FDA also gave approval to entrectinib for the treatment of adults with metastatic non–small cell lung cancer whose tumors are ROS1 positive.

Under a proposed rule released today, the agency would require new health warnings on cigarette packages and advertisements, which would feature pictures and images depicting some of the lesser-known health risks, including bladder cancer and heart disease.

Researchers aiming to better understand the role of estrogen in the development of Parkinson disease (PD) and its potential as a treatment found that brain-selective estrogen therapy resulted in motor improvements in male mice with PD-like symptoms.

Researchers showed the potential of combining 2 precision medicines to overcome treatment resistance.

Scientists uncovered a rare, inherited gene mutation, known as RABL3, that raises the risk of pancreatic and other cancers.

Planned Parenthood plans to withdraw from Title X program, amid looming Trump Administration rule changes; a new cure accepted by the FDA for a deadly strain of tuberculosis has been found to have a 90% success rate in a patient trial; opioid distribution to patients has began to change amongst doctors with new recommendations based around set prescribing levels.

Chronic active lesions, which are identified by their darkened outer rims, are associated with more aggressive multiple sclerosis and earlier disability, according to new research from the National Institute of Health.

While air pollution has long been associated with cardiovascular and respiratory diseases, this is believed to be the first longitudinal study of air pollution and emphysema progression.

Timothy R. Smith, MD, RPh, is president and chief executive officer of StudyMetrix Research. He is a fellow of the American College of Physicians and the American Headache Society, a certified physician investigator of the Academy of Clinical Research Professionals, and vice president of the National Headache Foundation. Dr Smith has a special interest in patient and physician issues related to the treatment of headache in primary care. This is part 2 of an interview conducted by an editor from The American Journal of Managed Care®.

The US Preventive Services Task Force is recommending screening all adults for illicit drug use; Senator Chuck Grassley, R-Iowa, is asking the FDA to perform more unannounced inspections of foreign drug manufacturing facilities; 5 years after Congress passed a law to reduce unneccessary diagnostic imaging tests, the law has yet to be implemented.

The viewpoint paints a picture of a challenge that is 2-fold: a growing amount of people are injecting opioids in rural communities, which is an emerging risk factor for HIV transmission, and these communities often lack the infrastructure or resources to prevent, diagnose, and treat HIV.

In Latin America, there has been slower uptake of newer therapies to treat multiple myeloma (MM) in public clinics versus private clinics, which has led to disparities in outcomes.

Women exposed to the chemical triclosan, which is found in products like soap and toothpaste, are at an increased risk for developing osteoporosis.

The National Institute of Allergy and Infectious Diseases, the World Health Organization, and the Congolese government announced that 2 experimental antibody-based treatments for Ebola are working so well that they will now be offered to all patients in the Democratic Republic of Congo; enrollment in insurance exchanges under the Affordable Care Act remains stable for people with lower incomes who received subsidies, but premium increases caused a 24% decline for people who did not qualify for assistance; scientists are repurposing old drugs or combining them with traditional antibiotics in an effort to combat antibiotic-resistant bacteria.

As disruptive medical technologies emerge, often unanticipated, bioethical issues arise, presenting challenges for employers navigating what benefits to offer to their employees.

Using data from 330 millennials responding to an online survey in December 2018, a Welltok survey revealed that 78% of the age group feel that employers are not doing enough to support their well-being.

Implementing a comprehensive social determinants of health program and addressing the root causes of medication nonadherence could mean the difference between a 3- and 4-star rating in Medicare Advantage.

As our country continues its push to lower the cost of healthcare, especially among the burgeoning population of seniors with age-related disabilities, transitioning to a value-based insurance design payment model that rewards value, rather than quantity, will become progressively more important. In the realms of musculoskeletal pain and movement dysfunction, this transition must be accompanied with sincere efforts to identify treatments that can effectively manage pain and reduce the total cost of care.

The Department of Homeland Security said that it was promoting the ideals of self-sufficiency, self-reliance, industriousness, and perseverance, but it also acknowledged that the vast majority of the 266,000-plus commenters on the rule opposed the change and noted that some people may decide to drop out of benefit programs.

New research is suggesting that measuring the pulse wave at a menopausal woman’s wrist may explain the increase in cardiovascular disease risk during menopause better than a standard blood pressure measurement.

A class-action trial begins Monday in Hartford, Connecticut seeking to end Medicare regulations around something called “observation care” in the hospital; California hospitals are providing significantly less free and discounted care to low-income patients because the Affordable Care Act reduced the number of uninsured patients; The American Academy of Pediatrics released its first policy statement about how racism affects the health and development of children and adolescents.

“Our data suggest that people with central obesity, insulin resistance, and active psoriasis are the most at risk for liver fibrosis,” wrote the authors, and “if use of methotrexate is a risk factor, it is not the only risk factor and for most patients it is unlikely to be the most important risk factor.”

The clinical manifestations of symptoms experienced by children and adolescents with narcolepsy can differ from those seen in adults, presenting barriers to a timely diagnosis.

A screening test could be used in clinical trials on prevention of the disease.

As survival rates for malignant melanoma increase, so does the likelihood that some patients will develop second primary cancers.

The clinical features of systemic inflammation in chronic obstructive pulmonary disease (COPD) are well recognized, but little is understood about the molecular mechanisms underlying this inflammation.

Patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma (MM), can progress from low- or intermediate-risk to MM in just 5 years, according to researchers who are now recommending all patients with MGUS undergo blood testing and risk assessment.

The authors said their study shows that implementing migraine guidelines into day-to-day clinical practice needs improvement.