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The researchers reported that aging brings degeneration of the circadian pacemaker, a progressive decline in melatonin output and decrease in rhythm amplitude which contributes to increasing sleep fragmentation and waking up earlier in the morning.

The results suggest that delaying initiation of disease-modifying therapy (DMT), especially after a poorly recovered relapse, decreases the likelihood of remaining disability free by age 45.

The workshops were aimed at ensuring that primary care centers were following clinical care guidelines developed after 2011 meeting requirements of a national certification program.

Testicular cancer is the most common cancer to be diagnosed in men as younger men—those younger than age 40—and it can be particularly aggressive. Advances in therapy have improved survival rates, but if young men have chemotherapy after surgery, they may live with side effects for decades.

This week, the top managed care stories included the FDA announcing a ban on flavored e-cigarettes; Google’s artificial intelligence system can find breast cancer as well as experts; new diabetes guidelines including 2 new drug classes to treat comorbidities.

No statistically significant difference in central macular thickness (CMT) between patients with and without diabetes was found preoperatively and in the early postoperative period after uncomplicated phacoemulsification surgery, according to study results.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Drug prices rose by 5.8% to start 2020, a slight decrease compared with last year's average increase; lower patient satisfaction shown after hospital mergers/acquisitions; study findings link exposure to secondhand smoke to risk of type 2 diabetes (T2D).

This week, researchers pinpointed the effects of shuttered automobile factories, releasing results in JAMA Internal Medicine that show plant closures from 1999 to 2016 were associated with increases in deaths from opioid overdoses.

In a recently published study in The Journal of Headache and Pain, Italian researchers compiled data on 548 patients suffering from chronic and episodic migraines enrolled in a tertiary level headache center to determine overall costs incurred.

Five issues in healthcare were spotlighted as key developments to watch; FDA to ban all e-cig vape flavors except for menthol and tobacco; Google AI system shown to improve detection of breast cancer through mammograms.

Splenomegaly, or enlargement of the spleen, is common in patients with Philadelphia-negative myeloproliferative neoplasms, and it is associated with symptoms like early satiety and abdominal pain. The role that splenomegaly has in terms of quality of life and prognosis in primary myelofibrosis is fairly well understood, but it has been less frequently investigated among patients with essential thrombocythemia (ET) and polycythemia vera (PV).

An executive with Jazz Pharmaceuticals said the ability to extend survival time in patients with secondary AML, and potentially offer them improved odds for transplant is an advance over traditional chemotherapy.

The results suggested that fusion events contribute to the complexity of acute myeloid leukemia and typically result from chromosomal rearrangements.

We polled our readers to find out which of 5 stories they thought was the most important healthcare story of the year. Here are the results.

Water fluoride concentrations were associated with higher odds of reports of snorting, gasping, or stopping breathing while sleeping at night.

Maximal inspiratory pressure (MIP) is associated with leg muscle strength in patients with chronic obstructive pulmonary disease (COPD), but not with walking distance or symptoms exhibited by the same patients, according to a recent study.

Patients with acute heart failure often require immediate treatment to restore optimal heart function. The 2 primary methods of revascularization are coronary artery bypass graft and percutaneous coronary intervention, but the preferred strategy for use in these patients requires clarification due to risk.

From linguistic dissonances of medical terminology to the generation of new care pathways for Medicare patients, the top 5 most-read articles of The American Journal of Accountable Care® spanned topics relevant to both patients and providers in 2019.

The motor and non-motor symptoms of patients with Parkinson Disease were shown to slightly improve with a weekly exercise regimen of physical and cognitive exercises, according to research presented at Future Physiology 2019.

There are 12 clinical trials underway investigating various combination treatments for HIV and AIDS, but a cure remains elusive. Few studies have attempted to qualify and quantify the risk HIV-positive individuals claim they would take if it meant a cure could result.

A recently published review in Frontiers in Immunology highlights the efficacy of Janus kinase inhibitors as treatments for several dermatological ailments, including psoriasis. Authors described how newly researched pathologic factors have changed therapeutic practices used to treat inflammation and autoimmunity.

Just as physical therapists (PT) or occupational therapists (OT) help patients overcome barriers to increased mobility, referral challenges can be overcome with the right people, processes, and technology.

In a recently published multicenter clinimetric study, researchers determined the extent to which the American Life Balance Inventory (LBI) is successful in measuring the same factors in several European countries.

The report suggests that removing barriers to coverage, as well as reducing medication costs for people with private insurance, would help decrease cost-related nonadherence to HIV therapies.

In a narrative review published in Frontiers in Neurology, researchers compiled evidence from various studies on the relationship between caffeine and migraines. From the data collected, researchers concluded that the relationship between them remains vague.

Advances in continuous glucose monitoring, reimbursement for genetic testing, and payment models in oncology care were popular with readers of the Evidence-Based series.