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This is part 2 of a 3-part vaccine series covering the potential of vaccines for infectious diseases, the impact of the antivaccination movement, and the promise of vaccines for cancer treatment.

Unreported exacerbations of chronic obstructive pulmonary disease (COPD) in clinical trials may be more prevalent than researchers realize, and this could cause them to underestimate the frequency of clinically significant exacerbations. This could affect the conclusions studies reach about the effectiveness of treatments.

A new study has identified lower rates of sexual anxiety among gay and bisexual men taking pre-exposure prophylaxis (PrEP).

Google and its sister companies are making substantial investments towards artificial intelligence in healthcare; the Trump administration seeks to remove protections for transgender individuals that allow equal access to healthcare; researchers identified 104 high-risk schizophrenia genes.

The addition of denosumab to aromatase therapy results in a significant reduction in clinical fractures and yields benefits for disease-free survival in postmenopausal women with hormone receptor–positive, early-stage breast cancer.

The Bold Goal Program began with the mission of improving health in target communities by 20% by 2020.

Researchers examined risk factors that could lead to frequent physical or mental stress in Americans with chronic obstructive pulmonary disease (COPD).

In a study of 29 virally suppressed patients who discontinued antiretroviral therapy (ART), every patient was able to maintain viral suppression from infusions of an antibody that blocks the HIV-binding site on CD4+ T cells.

A majority of physicians reported in 2018 that their financial situation had remained the same, and fewer said they were worse off compared with the previous year, according to the 90th annual Physicians Report.

Tests are scheduled to commence April 23rd for a malaria vaccine; the FDA has approved the first generic nasal spray for opioid overdose reversal; scientists have discovered a new broad-spectrum, arsenic-based antibiotic.

It's estimated that by 2021, 100 million people will have used a direct-to-consumer (DTC) genetic test. As these tests continue to gain popularity, there is a need for educating consumers on their DTC testing results and validating these results with confirmatory testing in a medical-grade laboratory.

In a proof-of-concept study recently published in Science Translational Medicine, researchers from Penn Medicine and the Children’s Hospital of Philadelphia were able to edit out a lethal lung disease using CRISPR in utero mice models.

Splenectomy before allogeneic hematopoietic stem cell transplantation (alloHSCT) might be a promising option in patients with myelofibrosis (MF) who failed to achieve significant spleen response after ruxolitinib therapy, according to results from a recently published study.

A recent retrospective study found that nearly 18% of patients diagnosed with multiple sclerosis (MS) before being referred to a medical center for treatment were actually misdiagnosed.

Further complications in patients with PD are seen when they enter an akinetic (medication OFF) and mobile phases (medication ON), demonstrated in 50% of patients diagnosed within 3-5 years, and 80% of patients diagnosed within 10 years. These fluctuations in motor function present a critical point in terms of managing the disease because it requires continued adjustments in treatment, such as changing the frequency and dosage amount or parameters for deep brain stimulation.

Biomarkers of Parkinson Disease, detected by smell and analysis of sebum, could lead to a noninvasive diagnostic test for the disease.

This week, the top managed care news included a study demonstrating that diabetes drug canagliflozin cuts the risk of renal failure and death; the FDA approving the first targeted therapy for metastatic bladder cancer; approximately half of all cancer deaths are attributable to modifiable risk factors.

The percentage of US adults who used strategies to reduce prescription drug costs, such as skipping medication doses, asking the doctor for a lower-cost medication, and using alternative therapies, was stable from 2015 to 2017 and was down from 2013 to 2015.

https://www.pharmacytimes.org/on-demand/impact-of-von-willebrand-disease-on-costs-and-patient-outcomes-featuring-a-patient-perspective-enduring

Circulating tumor DNA (ctDNA) can be analyzed in patients with cancer to detect minimal residual disease (MRD). Two abstracts, presented at the American Association for Cancer Research Annual Meeting 2019, evaluated ctDNA analysis and ways of tracking MRD.

The April issue of The American Journal of Managed Care® (AJMC®) featured research on deaths in opioid users, colorectal cancer screening, and health system competition. Here are 5 findings from research published in the issue.

Washington is set to become the first state to offer long-term care benefits for those who pay into the program; a genome-wide polygenic score can predict the odds of obesity; and Montana is moving to reauthorize Medicaid expansion with the addition of community engagement requirements.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

In rare cases, despite being on antiretroviral therapy and being virally suppressed, patients experience extreme immune decline.

Locations in Ohio, Kentucky, New York, and Massachusetts were selected for an opioid abuse prevention and treatment initiatives as part of a multimillion dollar interagency federal research effort, led by the National Institutes of Health.

Shoshana Lipson, a patient advocate and founder of the “ CGRP & Migraine Community ” on Facebook explains how the group works to support patients with migraine.

Heart disease was the number one reason for “excess deaths” after Hurricane Maria struck Puerto Rico in September 2017.