Clinical

Strategies used during the COVID-19 pandemic to ensure continuity of care in people living with HIV can be used as a paradigm of adaptability during unexpected crises.

Investigators found patients receiving chemotherapy had a greater risk of a secondary primary malignancy (SPM) compared with those treated with targeted therapies or those whose chronic lymphocytic leukemia (CLL) was left untreated.

The gene therapy delandistrogene moxeparvovec-rokl, also known as Elevidys (Sarepta Therapeutics) is indicated to treat Duchenne muscular dystrophy (DMD) in ambulatory patients aged 4 to 5 years, and Sarepta recently filed supplemental data with the FDA seeking to expand the labeled indication.

Several risk factors put patients with colorectal cancer at increased risk of anastomotic leakage after elective surgery.

Natasha Halasa, MD, MPH, of Vanderbilt University Medical Center (VUMC), discusses the active population-based surveillance that the New Vaccine Surveillance Network conducts.

With their closing thoughts, the panelists provide their key takeaways from this discussion surrounding the operationalization of bispecifics.

Experts underscore cost relief of bispecific antibodies via medication assistance programs.

Compared with patients with only chronic obstructive pulmonary disease (COPD), patients with COPD and anxiety and/or depression had increased clinical and economic burden.

Efficacy against chronic lymphocytic leukemia (CLL) was seen when tested as both a single agent and in combination with antitumor antibody.

Ann LaCasce, MD, MMSc, director of the Dana-Farber/Mass General Brigham Fellowship in Hematology/Oncology and chair of the Lymphoma Research Foundation’s Scientific Advisory Board, discusses potential shifts in the lymphoma space in the year ahead.

Dr Metersky provides his closing thoughts, highlighting key points of emphasis surrounding bronchiectasis care and the future of its treatment landscape.

In patients with high-grade ovarian cancer, an increased proportion of CD3+ CD137+ tumor infiltrating lymphocytes (TILs) correlated with favorable overall survival outcomes. However, proportions of CD3+ or CD3+ CD8+ TILs did not show significant associations with OS.

Dupilumab and topical corticosteroids can be used to treat symptoms in children with atopic dermatitis (AD).

The increased risk is likely due to the underlying cancer disease and adjuvant treatments, researchers find.

Pandemic-era policies that made it easier for patients to receive opioid addiction treatment will continue permanently; the Biden administration is facing pressure from Democrats and reproductive health groups to make sure the first OTC birth control pill is affordable; a FDA expert panel on Friday is set to resume the debate over how to make pulse oximeters more accurate for people with darker skin.

Although rates of opioid use disorder (OUD) are higher than previous estimates, OUD was relatively stable or decreasing over time in patients with HIV.

Experts discuss the necessity of ESR1 mutation testing when considering treatment with elacestrant in patients with estrogen receptor–positive (ER+)/HER2-negative (HER2–) metastatic breast cancer and discuss unmet needs in this patient population. They also describe options for mutation and resistance marker testing to guide treatment selection.

The findings not only underscore the efficacy of 2 major interventions—Behavioral Activation Psychotherapy (BA) and Antidepressant Medication Management (MEDS)—but also support patient autonomy in choosing their preferred path to mental well-being.

This systematic review found COVID-19 disruptions on clinical outcomes in those with diabetes to be more pronounced for females, younger people, and those a part of racial and ethnic minority groups.

Inhaled chronic obstructive pulmonary disease (COPD) medications prescribed before surgery in patients with early-stage non–small cell lung cancer (NSCLC) were associated with both short- and long-term outcomes.

Natasha Halasa, MD, MPH, Vanderbilt University Medical Center, discusses her role as principal investigator of the Vanderbilt site of the New Vaccine Surveillance Network.

CMS released the proposed 2025 Advance Notice for the Medicare Advantage (MA) and Medicare Part D Prescription Drug Programs; there have been 561 deaths related to the use of Philips’ recalled ventilators and machines for treating obstructive sleep apnea since 2021; the FDA warned the public against copycat eye drops due to infection risk.

Safety considerations for BTKi use in CLL and SLL treatment are highlighted.

Dr Haumschild drives a discussion surrounding the role of bruton kinase inhibitors for treating CLL and SLL.

Children and adolescents were at higher risk for myopic maculopathy progression if they had worse best-corrected visual acuity and longer axial length, among other risk factors.

An expert ophthalmologist discusses a medication which targets enzymes in the Demodex mite, given over a six-week course. 

Aducanumab’s accelerated approval was controversial and insurance coverage of the expensive therapy was limited.

Neda Shamie, MD, summarizes the prevalence and clinical manifestations of Demodex Blepharitis.

Sickle cell disease (SCD) will be the first focus of the Cell and Gene Therapy (CGT) Access Model; the FTC has challenged the validity of over 100 drug product patents to help increase competition and potentially lower prices; the rate of infectious syphilis cases in the US rose 9% in 2022.

However, the association between familial hypercholesterolemia variants and coronary heart disease slightly weakened after adjusting for baseline low-density lipoprotein cholesterol (LDL-C) level and became statistically insignificant after adjusting for cumulative past LDL-C exposure.