Immunotherapy Landscape in cSCC and BCC

EP: 1.Prevalence of Cutaneous Squamous Cell Carcinoma (CSCC) & Basal Cell Carcinoma (BCC)

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EP: 2.Immunotherapy Landscape in cSCC and BCC

EP: 3.Immunotherapy and Radiation Therapy in cSCC and BCC

EP: 4.Immunotherapy Barriers: Multidisciplinary Approach in cSCC and BCC

EP: 5.Coordination of Care: Interdisciplinary Immunotherapy Challenges in Nonmelanoma Skin Cancers

EP: 6.Multidisciplinary Collaboration: Best Practices for CSCC and BCC Management

EP: 7.Dermatologists and Immunotherapy: Managing Patient Expectations

EP: 8.Monitoring Immunotherapy Toxicities in CSCC and BCC

EP: 9.Staging Disease and Risk Stratification in CSCC and BCC

EP: 10.Targeted Therapy: Hedgehog Inhibitors in BCC

EP: 11.Socioeconomic Implications of CSCC and BCC

EP: 12.Immunosuppression in CSCC and BCC Treatment

EP: 13.Updates in Therapeutics for Nonmelanoma Skin Cancers

EP: 14.Concluding Thoughts on the Future of CSCC and BCC Care

This is a video synopsis/summary of a Peer Exchange involving Jason Luke, MD, FACP; Christopher Barker, MD; Omid Hamid, MD; Vishal Patel, MD; and Catherine Pisano, MD.

Patel explained that while most basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (cSCCs) are treated surgically, a subset of patients with recurrent, advanced or metastatic disease require systemic therapy. He noted systemic treatment is also considered for some patients with a high disease burden for whom surgery would be excessively disfiguring or challenging. Luke highlighted the increasing use of immunotherapy in the neoadjuvant setting across cancer types to facilitate organ preservation and improve outcomes. Hamid discussed a neoadjuvant trial in cSCC that demonstrated high pathologic complete response rates and helped make previously unresectable tumors suitable for surgery. The discussants agreed that the impressive responses observed with neoadjuvant cemiplimab set the stage for testing shortened treatment courses and even nonsurgical management in some cSCC patients.

Video synopsis is AI-generated and reviewed by AJMC editorial staff.