Ruxolitinib Cream and Atopic Dermatitis at AAD 2025

• Now, let’s shift our focus to AD. and the emerging role of immune modulators in the treatment of AD. Please discuss the findings presented at AAD 2025 regarding the association of ruxolitinib cream initiation with a reduction in the use of other topical treatments, oral corticosteroids, and biologics for atopic dermatitis, regardless of previous use of biologics.
  • What was the objective of this study?
  • How was this study designed/what methodology was used?
  • What results were presented?
    • n = 556
      • n = 125 biologics during baseline period
      • n = 431 no baseline biologic use
    • Topical treatment use for AD before/after initiation of ruxolitinib cream
      • Biologic-experienced
      • Biologic naive
    • Oral corticosteroid use before/after initiation of ruxolitinib cream
      • Biologic-experienced
      • Biologic naive
    • Biologic use for AD before/after initiation of ruxolitinib cream

• What are your key takeaways from this study, and how do the results influence your perspective on long-term options for the treatment of atopic dermatitis?

• In your current practice, where does ruxolitinib fit in as a treatment option for atopic dermatitis, and how do you determine when to initiate? What are benefits and drawbacks that need to be considered when choosing immunomodulators such as JAK inhibitors for AD?

How has the use of immune modulators and biologics evolved over time, and how do you foresee the atopic dermatitis treatment paradigm changing moving forward?