Breast Cancer

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FDA approval | Image Credit: BHM - stock.adobe.com

FDA Approves Datopotamab Deruxtecan for HR-Positive/HER2-Negative Metastatic Breast Cancer

By Pearl Steinzor

January 17th 2025

The approval is based on findings from the phase 3, multicenter, open-label, randomized TROPION-Breast01 trial.

Marie-France Jilderda, MD, PhD Candidate Surgical Oncology at Leiden University Medical Center in the Netherlands.

BCI Shows Promise of Personalized Endocrine Therapy in Breast Cancer

By Cameron Santoro

January 15th 2025

Marie-France Jilderda, MD, PhD Candidate Surgical Oncology at Leiden University Medical Center in the Netherlands.

Identifying Patients With Low-Risk Breast Cancer for De-escalated Therapy

By Cameron Santoro

January 13th 2025

Elinzanetant | Image credit: Basstock - stock.adobe.com

Elinzanetant Excels in Phase 3 Study for Vasomotor Symptom Relief

By Pearl Steinzor

January 9th 2025

Breast cancer research. | Image Credit: Chinnapong - stock.adobe.com

Impact of Sexual Counseling on Women With Breast Cancer

By Pearl Steinzor

January 8th 2025

Advances in CDK4/6 Inhibitor Use in High-Risk Early Breast Cancer: 2024 Updates

Experts discuss the impact of CDK4/G inhibitor use, including medication cost, total care costs, toxicity profiles, and strategies to manage and optimize patient outcomes in high-risk early breast cancer.

Watch the latest AJMC Peer Exchange on Advances in CDK4/6 Inhibitor Use in High-Risk Early Breast Cancer: 2024 Updates

More News

Previous Breast Cancer Therapy Not Likely to Affect Outcomes in Patients With COVID-19

June 26th 2020

Previous Breast Cancer Therapy Not Likely to Affect Outcomes in Patients With COVID-19

Results from an analysis of patients with breast cancer and coronavirus disease 2019 (COVID-19), from Institut Curie hospitals in France, show that mortality is determined more by comorbidities than previous or current treatment for the cancer.

Black Women With Insulin Resistance May Have Worse Breast Cancer Prognosis

June 24th 2020

Black Women With Insulin Resistance May Have Worse Breast Cancer Prognosis

Elevated insulin levels, which have been shown to promote tumor growth, due to insulin resistance may be linked to a greater prevalence of invasive breast cancer among black women compared with white women.

How Much Influence Do Chronic Diseases Exert on Mammography Screening?

June 19th 2020

How Much Influence Do Chronic Diseases Exert on Mammography Screening?

There is a positive association between having at least 1 chronic disease and adhering to guidelines for breast cancer screening, according to recently published study results.

Two-Thirds of Patients With TNBC Do Not Receive Recommended Care

June 16th 2020

Two-Thirds of Patients With TNBC Do Not Receive Recommended Care

Cases of triple-negative breast cancer (TNBC) account for up to 20% of all cases of the disease, the most common cancer diagnosed in women in the United States.

High-Dose Chemo Most Benefits Patients With High-Risk Breast Cancer

June 11th 2020

High-Dose Chemo Most Benefits Patients With High-Risk Breast Cancer

A 20-year follow-up comprising a secondary analysis to an original study shows that high-dose chemotherapy plus hematopoietic stem cell transplant benefit patients with high-risk stage III disease with 10 or more axillary lymph nodes involved.

Postmenopausal Women With Breast Cancer Show Decreased Brain Health, Cognitive Function

June 8th 2020

Postmenopausal Women With Breast Cancer Show Decreased Brain Health, Cognitive Function

Previous studies show that up to 75% of women with breast cancer exhibit disease- and treatment-related affects that include poorer cognitive function in the forms of psychological well-being, decision making, and adherence to treatment.

Optimal Survival May Depend on Timing of Paclitaxel, Study Says

June 5th 2020

Optimal Survival May Depend on Timing of Paclitaxel, Study Says

There are more than 50 drug regimens available to treat metastatic breast cancer but little guidance on the best order to deliver them, according to a study published in JCO Clinical Cancer Informatics.

Breast Cancer Surgery Rate Decreases With Older Age, UK Study Says

June 3rd 2020

Breast Cancer Surgery Rate Decreases With Older Age, UK Study Says

Older age was shown to influence the decision among women to undergo surgery as a treatment option following a diagnosis of breast cancer in the United Kingdom, where the average lifespan was 82.9 years in 2016.

Is Prepectoral Breast Implant Reconstruction After Mastectomy Safe?

May 29th 2020

Is Prepectoral Breast Implant Reconstruction After Mastectomy Safe?

Following decades that saw its popularity dwindle in favor of subpectoral breast reconstruction, prepectoral breast reconstruction is once again on the rise.

Long-Term Risk of Invasive Breast Cancer Increases Following a Diagnosis of DCIS

May 28th 2020

Long-Term Risk of Invasive Breast Cancer Increases Following a Diagnosis of DCIS

In the 2 decades following their diagnosis for ductal carcinoma in situ (DCIS), women in a study out of England demonstrated a greater risk of invasive breast cancer and mortality compared with the general population. Overall, DCIS represents close to 20% of screening-detected breast cancers every year.

Women Frequently Encounter Employment, Insurance Issues After Breast Cancer Diagnosis

May 24th 2020

Women Frequently Encounter Employment, Insurance Issues After Breast Cancer Diagnosis

A majority of women younger than 45 years faced employment and insurance coverage difficulties following treatment for early stage breast cancer, with 35% fearing loss of health insurance coverage if they left their current job during treatment—despite wanting to continue working.

Patients With Breast Cancer, COVID-19 Fared Well in Recent Study

May 20th 2020

Patients With Breast Cancer, COVID-19 Fared Well in Recent Study

A small trial out of Columbia University Irving Medical Center shows encouraging recovery results among patients with breast cancer who contracted coronavirus disease 2019 (COVID-19), which was confirmed by reverse transcription-polymerase chain reaction, and/or high clinical or radiographic suspicion. Hospitalization was not necessary for nearly three-quarters of the patients.

Adverse Outcomes in Breast Cancer Are Magnified When Patients Have Poor Heart Health

May 16th 2020

Adverse Outcomes in Breast Cancer Are Magnified When Patients Have Poor Heart Health

Female survivors of breast cancer total over 3.5 million in the United States alone. Coronary heart disease is a leading cause of death among this patient group, as it is for all women.

Advanced, Fatal Breast Cancers Reduced Through Mammography Screening

May 11th 2020

Advanced, Fatal Breast Cancers Reduced Through Mammography Screening

Fatal breast cancers were reduced by 41% and advanced breast cancers by 25% following recommended screening for the disease by mammography in 9 counties in Sweden, emphasizing the importance of early detection.

Study Attempts to Define Gains From Chemo for HR-Positive, HER2-Positive Breast Cancer

May 9th 2020

Study Attempts to Define Gains From Chemo for HR-Positive, HER2-Positive Breast Cancer

Compared with tumors smaller than 8 mm among patients with hormone receptor (HR)-positive, ERBB2-positive (formerly HER2-positive) breast cancer, tumors between 8 and 10 mm benefited more from postoperative chemotherapy.

Consensus Called for When Choosing Optimal Treatment for Breast Cancer–Related Lymphedema

May 7th 2020

Consensus Called for When Choosing Optimal Treatment for Breast Cancer–Related Lymphedema

More than 20% of breast cancer survivors are severely affected by breast cancer–related lymphedema, with debilitating adverse effects that include depression, chronic pain, and recurrent skin infections—all affecting overall quality of life.

AJMC® in the Press, May 1, 2020

May 1st 2020

AJMC® in the Press, May 1, 2020

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Phase 3 EMBRACA Findings Suggest No Overall Survival Benefit With Talazoparib in Advanced BRCA-Mutated Breast Cancer

April 28th 2020

Phase 3 EMBRACA Findings Suggest No Overall Survival Benefit With Talazoparib in Advanced BRCA-Mutated Breast Cancer

Matthew Gavidia

In new data from the phase 3 EMBRACA trial presented yesterday at the American Association for Cancer Research annual meeting, researchers found that PARP inhibitor talazoparib exhibited no statistically significant benefit in the secondary end point of overall survival in patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

Does Posttreatment Weight Loss Equate to Improved Quality of Life Among Survivors of Breast Cancer?

April 27th 2020

Does Posttreatment Weight Loss Equate to Improved Quality of Life Among Survivors of Breast Cancer?

An international team of investigators recently tried to answer this question, focusing on women with diagnosed early-stage disease and considered obese, with a body mass index above 30 kg/m2.

FDA Approves Trodelvy for Metastatic Triple-Negative Breast Cancer

April 22nd 2020

FDA Approves Trodelvy for Metastatic Triple-Negative Breast Cancer

The FDA granted accelerated approval to Immunomedics’ Trodelvy (sacituzumab govitecan-hziy) as the first antibody-drug conjugate that targets the Trop-2 antigen. Trodelvy is indicated for treatment of relapsed or refractory metastatic triple-negative breast cancer (TNBC) that has spread to other parts of the body.

Can Melatonin Alleviate Symptoms of Cognitive Impairment in Patients With Breast Cancer?

April 22nd 2020

Can Melatonin Alleviate Symptoms of Cognitive Impairment in Patients With Breast Cancer?

Cognitive impairment is a well-documented adverse effect of treatment from breast cancer. Complications from it can appear soon after treatment has begun or far down the road.

How Are Breast Cancer and Obesity Related? Possible New Link Discovered

April 18th 2020

How Are Breast Cancer and Obesity Related? Possible New Link Discovered

There is a greater risk of hormone receptor–positive breast cancer if a patient is obese. Researchers from the University of Louisville have discovered a possible new link between obesity and a greater risk for developing breast cancer: adipose fatty acid binding protein.

Oncology Groups Issue Preliminary COVID-19 Triage Guidelines for Breast Cancer

April 16th 2020

Oncology Groups Issue Preliminary COVID-19 Triage Guidelines for Breast Cancer

Several prominent oncology organizations, including the National Comprehensive Cancer Network and the Commission on Cancer, have joined forces to issue preliminary guidelines on how to treat patients with breast cancer during the coronavirus disease 2019 (COVID-19) pandemic.

Regular Exercise Confers a Significant Survival Benefit Among Patients With Breast Cancer

April 10th 2020

Regular Exercise Confers a Significant Survival Benefit Among Patients With Breast Cancer

Meeting HHS’ minimum requirements for daily and weekly exercise reduced breast cancer recurrence and mortality among patients with high-risk breast cancer undergoing chemotherapy. This benefit was even seen in patients who had not met these requirements before their diagnosis.

Study Results Show Pembrolizumab Plus Chemotherapy May Be Effective in Patients With TNBC

April 9th 2020

Study Results Show Pembrolizumab Plus Chemotherapy May Be Effective in Patients With TNBC

The standard therapy for triple-negative breast cancer (TNBC) remains chemotherapy, despite a dismal prognosis due to lack of estrogen and progesterone hormone receptors, as well as HER2 receptors. Targeted therapies for this difficult-to-treat, often aggressive, subtype of breast cancer remain elusive.

April 4th 2020

White Blood Cell Profile Linked to Greater Breast Cancer Risk

What can be done to further delineate the risk factors associated with breast cancer to increase prevention efforts across the board? The key may lie in the white blood cells that circulate in the blood, particularly leukocytes and monocytes.

Genetic Testing May Benefit Older Women With Breast Cancer

April 2nd 2020

Genetic Testing May Benefit Older Women With Breast Cancer

The 2 main criteria that warrant genetic testing for breast cancer in women are age and having a family history of cancer. Postmenopausal women without any hereditary risk factors, however, often do not undergo genetic testing for the disease.

AB MRI Shown to Improve Cancer Detection Rate in Women With Dense Breast Tissue

March 26th 2020

AB MRI Shown to Improve Cancer Detection Rate in Women With Dense Breast Tissue

Not all women with dense breast tissue have a high risk of breast cancer, but they all have an increased risk compared with women who have average tissue density. Can this patient population benefit from screening with abbreviated breast magnetic resonance imaging (AB MRI) over digital breast tomosynthesis?

What Is the Relationship Between Hormone-Modulating Therapies and Incidence of Neurodegenerative Diseases?

March 24th 2020

What Is the Relationship Between Hormone-Modulating Therapies and Incidence of Neurodegenerative Diseases?

Two hormone-modulating breast cancer therapies (HMTs), tamoxifen and steroidal aromatase inhibitors, were associated with a decrease in the number of women who received a diagnosis of a neurodegenerative disease, according to a study published in JAMA Network Open. Specifically, the 2 HMTs were associated with significant decreases in diagnoses of Alzheimer disease and dementia.

Does Treatment Begin and End Sooner With Neoadjuvant or Adjuvant Chemotherapy?

March 13th 2020

Does Treatment Begin and End Sooner With Neoadjuvant or Adjuvant Chemotherapy?

Patients who undergo neoadjuvant chemotherapy tend to be younger, with larger tumors and greater nodal involvement. But differences in their 30- and 90-day mortality rates compared with those of patients treated adjuvantly are clinically insignificant.

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