Myelodysplastic Syndromes

Latest News
December 11th 2024

Molecular Lesions in Low-Risk Myelodysplastic Neoplasms Disrupt Prognostic Model for Leukemia

December 11th 2024

Additional Hematopoietic Malignancy Predispositions Accounted for in Updated Surveillance Recommendations

November 29th 2024

Survivors of Childhood Cancer at 9-Fold Greater Risk for Late Subsequent Leukemia 

November 27th 2024

Venetoclax May Be an Option for Children With R/R AML, MDS

November 11th 2024

Increased Surveillance Recommended for Children at Risk for Hematopoietic Malignancy Predisposition

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March 17th 2024

Dr Jennifer Vaughn: We Can Provide Aggressive, Effective Treatment, but Help Patients Maintain Quality of Life

February 3rd 2023

Treatment Patterns in the Management of MDS

January 27th 2023

Treatment Paradigm in Lower-Risk MDS (LR-MDS) Patients

January 20th 2023

TP53 Mutation and Its Impact on Patient Outcomes in MDS

December 29th 2022

Age Considerations for Findings on Venetoclax Combined With CLIA for AML, High-Risk MDS

December 23rd 2022

Dr Patrick Reville: How Patients With MDS, MPAL Responded to Venetoclax With CLIA

December 21st 2022

ASCERTAIN Trial Overview

December 16th 2022

Dr Patrick Reville Covers Study Results on Venetoclax Combined With CLIA

November 15th 2022

Key Considerations for Overall MDS Treatment Management

November 15th 2022

Future Treatment of MDS

More News

stem cells | Image Credit: © jarun011 -stock.adobe.com
November 8th 2024

Study Explores Radiation-Free Transplant Approach for Patients With Dyskeratosis Congenita

Kimberly Rath, PharmD
A new study finds that eliminating radiation from conditioning regimens in patients with dyskeratosis congenita undergoing allogeneic hematopoietic cell transplantation did not negatively affect survival or increase complications.
Blood cells from blood marrow biopsy | image credit: Катерина Євтехова - stock.adobe.com
November 2nd 2024

Patients With MDS Disagree With Physicians About Symptom Frequency

Jared Kaltwasser
Physicians also differed from caregivers when asked how many hours of caregiving patients required each week.
Myeloid malignancy concept, blood cells floating | image credit: Eleni - stock.adobe.com
October 18th 2024

Phase 1b/2 Study Supports Use of Telaglenastat and Azacytidine in Advanced MDS

Kimberly Rath, PharmD
A recent study evaluates the dosing, safety, and efficacy of telaglenastat and azacytidine to treat advanced myelodysplastic syndromes (MDS), with promising results.
Cancer cells | Image credit: Sodapeaw - stock.adobe.com
October 11th 2024

In Lower-Risk MDS, Genomic Dynamics Heighten Likelihood of Treatment

Jared Kaltwasser
The study is among the first to look at the potential impacts of clonal dynamics on patients with lower-risk myelodysplastic syndromes (MDS).
Doctor consulting with patient | Image credit: ARMMY PICCA - stock.adobe.com
October 4th 2024

JAK Inhibitors Show Promise in Concurrent Myeloid Disorders, IADs

AJMC Contributor
In recent years, it’s been estimated that 10% to 28% of patients with myeloid disorders develop adult onset inflammatory and autoimmune disorders (IADs), complicating treatment.
Hemoglobin is responsible for transporting oxygen throughout the body, which is imperative for a multitude of functions | image credit: Justlight - stock.adobe.com
September 21st 2024

Low Hemoglobin, IDH2 Mutation Indicative of Poor Survival in MDS

Nameera Temkar, MD
Results from a retrospective study compared and explored biomarkers associated with outcomes in myelodysplastic syndrome (MDS) with plasma cell neoplasms.
Celiac disease and the body | Image Credit: reineg-stock.adobe.com
September 13th 2024

Celiac Disease Associated With Varying Risks for Cancers

Karen Jacobson-Sive
Celiac disease presents a higher risk for developing malignant neoplasms, including small intestine, lymphoma, and skin cancers, but presents a lower risk for respiratory malignancies.
Telomeres act as protective caps on the ends of chromosomes | image credit: Anastasiia - stock.adobe.com
September 3rd 2024

RIOK2 Regulates Telomerase Subunits to Prevent Telomere Shortening

Gwen Mergian
New research linking telomere shortening to myelodysplastic syndromes (MDS) offers substantial therapeutic implications for affected patients and MDS research.
Patient takes medicine | Image Credit: © Seventyfour - stock.adobe.com
August 25th 2024

High Patient Satisfaction Seen With Oral DEC-C in Myelodysplastic Syndromes

Kimberly Rath, PharmD
Patients with myelodysplastic syndromes report high satisfaction with oral decitabine/cedazuridine (DEC-C) vs traditional intravenous or subcutaneous hypomethylating agents.
red blood cells | Image Credit: kolonko-stock.adobe.com
August 23rd 2024

Clinical, Economic Outcomes Associated With Alloimmunization in MDS

AJMC Contributor
The researchers found inferior outcomes and higher accrued costs associated with alloimmunization in patients with myelodysplastic syndromes (MDS), a disease that relies on transfusion of red blood cells.
Guidelines folder | Image Credit: tashatuvango-stock.adobe.com
August 16th 2024

New Guidelines Clarify MDS Classification, Highlight Diagnostic Nuances

Gayle Turim Dickstein
Authors acknowledge that both the 2022 World Health Organization and International Consensus Classification myelodysplastic syndrome criteria sets have value, while sorting out their similarities and differences.
science and teamwork | Image Credit: Coetzee peopleimages-stock.adobe.com
August 9th 2024

Lab Technology Advances Detection of MDS

Gayle Turim Dickstein
More and more hematology factors and parameters can be analyzed with advanced equipment to better pinpoint which patients might have myelodysplastic syndromes (MDS)—but the differences in leading makers’ systems can be tricky to maneuver.
MDS wooden blocks | Image Credit: Sviatlana - stock.adobe.com
August 2nd 2024

Report: ESAs Largely Ineffective in Lower-Risk MDS

Jared Kaltwasser
Only about a quarter of patients who have myelodysplastic syndrome (MDS) experienced hematologic improvement with erythropoiesis-stimulating agents (ESAs).
stem cell transplant | Image Credit: Vadim-stock.adobe.com.jpeg
July 28th 2024

HCT Outcomes Show Improvement With Posttransplant Cyclophosphamide

Karen Jacobson-Sive
Post–hematopoietic cell transplantation (HCT) prophylaxis using cyclophosphamide to stave off graft-vs-host disease had positive results compared with calcineurin inhibitor–based prophylaxis, regardless of whether the patient had a matched or unmatched donor.
MDS test | Image Credit: Saiful52-stock.adobe.com
July 22nd 2024

Study Identifies Risk Factors for Progression From Low-Risk MDS

Jared Kaltwasser
The findings show most patients with low-risk myelodysplastic syndrome (MDS) will die before progression.
transfusion setup | Image Credit: Parilov-stock.adobe.com
July 15th 2024

Sponsor Terminates MATTERHORN Trial of Roxadustat for Low-Risk MDS

Jared Kaltwasser
Patients with myelodysplastic syndrome (MDS) in the treatment arm were more likely to achieve transfusion independence, but the difference vs placebo was not statistically significant.
Telehealth solutions | Image Credit: Dmitry - stock.adobe.com
July 10th 2024

Telehealth Can Drive More Meaningful Serious Illness Conversations in MDS, AML

AJMC Contributor
Researchers collected feedback from 20 clinicians implementing a telehealth serious illness conversation (SIC) with their patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Giving bad news | Image Credit: engagestock-stock.adobe.com
July 3rd 2024

VEXAS Syndrome Often Misdiagnosed as Pyoderma Gangrenosum

AJMC Contributor
In a recently published systematic review, researchers determined that VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome typically presents in men, with atypical morphology and with systemic symptoms.
MDS panel | Image Credit: MdBabul-stock.adobe.com
June 27th 2024

Clinicians, Caregivers, Patients: MDS Treatment Preferences Explored

Kimberly Rath, PharmD
Study findings provide new tools to assess treatment preferences when using hypomethylating agents in myelodysplastic syndromes (MDS).
myelodysplastic disease diagnosis | Image Credit: ibreakstock-stock.adobe.com
June 19th 2024

How Inflammation Factors May Influence Lower-Risk MDS

Gayle Turim Dickstein
Determining the roles that various inflammatory markers and pathways play in lower-risk myelodysplastic syndromes (MDS) could lead to therapies that keep disease progression at bay.
Gut microbiome | Image Credit: © sdecoret - stock.adobe.com
June 13th 2024

Gut Microbiota Found to Influence MDS Risk Through Immune Cells

Kimberly Rath, PharmD
Researchers have identified a causal link between gut microbiota and myelodysplastic syndrome (MDS) risk, mediated by certain key immune cell phenotypes.
Scientific investigation | Image Credit: makibestphoto-stock.adobe.com
June 5th 2024

Consortium: PROs Have Key Role in MDS Trials

Jared Kaltwasser
The coalition said, however, that patient-reported outcomes (PROs) in the myelodysplastic syndrome (MDS) space will be most meaningful if they are collected rigorously and if the data are transparent.
MDS Panel | Image Credit: MdBabul-stock.adobe.com
May 22nd 2024

Key Factors Significantly Associated With ESA Response in Lower-Risk MDS

Luke Halpern
Hemoglobin levels, transfusion independence, and low serum erythropoietin levels were all deemed to have a statistically significant relationship with erythropoiesis-stimulating agent (ESA) response.
MDS blood test | Image Credit: MdBabul-stock.adobe.com
May 16th 2024

Decitabine, Venetoclax Combo Boosts Survival in Patients With AML and MDS

Kimberly Rath, PharmD
Study findings demonstrate that combining decitabine with venetoclax enhances molecular response rates in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), correlating strongly with improved clinical outcomes and overall survival.
MDS graphic | Image Credit: MdBabul-stock.adobe.com
May 8th 2024

Diagnostic Oversights Limit Luspatercept Benefits in MDS

Gayle Turim Dickstein
Investigators of a retrospective study encourage colleagues to utilize molecular testing for patients with an established diagnosis of lower-risk myelodysplastic syndromes (MDS), to be sure they don’t miss out on treatments, like luspatercept, for which they qualify.
Medicine doctor hold icon health and electronic medical record on interface. Digital healthcare and network connection on hologram virtual screen, insurance. medical technology and network concept | Image Credit: © ipopba - stock.adobe.com
April 30th 2024

Machine Learning and Neural Network Can Be Effective Diagnostic Tools in MDS, Study Finds

Jared Kaltwasser
The investigators said their new system makes it possible for researchers to leverage artificial intelligence even if they do not have expertise working with advanced software.
MDS graphic | Image Credit: Sviatlana - stock.adobe.com
April 15th 2024

Improving Cancer Care: The Role of Oral Hypomethylating Agents and Education

Jared Kaltwasser
Investigators say oral formulations of hypomethylating agents could be a significant advancement for people with myelodysplastic syndromes and acute myeloid leukemia.
Myelodysplastic syndrome written on a clipboard | Image Credit: syahrir - stock.adobe.com
April 11th 2024

TP53-Mutated MDS/AML Posttransplant Treatment Gaps

Luke Halpern
The rate of relapse among patients with TP53-mutated myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) was similar among those who underwent allogeneic hematopoietic stem cell transplant vs those who did not.
Laptop with words Myelodysplastic Syndrome | Image Credit:Yurii Kibalnik - stock.adobe.com
April 4th 2024

Heterogeneous Practices Common in Treatment, Monitoring of Patients With Myelodysplastic Syndrome With Del(5q)

Luke Halpern
This study builds on previous evidence for lenalidomide-induced selective advantage for TP53-mutant clones.
Concept of Meylodysplastic Syndrome | Image Credit: syahrir - stock.adobe.com
March 26th 2024

Venetoclax Resistance in Patients With MDS Explained in New Study

Jared Kaltwasser
The report offers new insights into the limits of the BCL2 inhibitor among patients who have myelodysplastic syndromes.
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