Skin Cancer

The AJMC® Skin Cancer compendium is a comprehensive resource for clinical news and expert insights about melanoma and other skin cancers.

Latest News

Reconstruction following removal of nasal BCC is often required, even with soft tissue defects. | Image credit: Viktoriia - stock.adobe.com
Immediate Nasal Reconstruction Following BCC Removal Is Viable

April 28th 2025

Immediate local flap or skin graft following basal cell carcinoma (BCC) can be considered, a study found.

Within 5 years, the risk of SCC in particular was heightened among patients with MMP. | Image credit: wavebreak3 - stock.adobe.com
Rare Autoimmune Disorder Linked With Increased Risk of Certain Skin Cancers

April 21st 2025

Patients who stopped adjuvant immunotherapy less than 12 months following metastatic melanoma resection did not experience inferior outcomes. | anna.stasiia - stock.adobe.com
Early Adjuvant Immunotherapy Discontinuation Does Not Affect Melanoma Recurrence Risk

April 17th 2025

Patient self reporting or intentional physical examinations by clinicians remain the main avenues by which suspected skin cancers are identified. | Image credit: anna.stasiia - stock.adobe.com
Novel Methods Could Reshape Skin Cancer Diagnostics

April 10th 2025

Woman with keloid on shoulder | Image credit: weerajata – stock.adobe.com
Deep Learning Tool Differentiates Keloids From Malignant Lesions Without Dermoscopy

April 2nd 2025

Dr. Jason Luke leads a panel discussing immunotherapy advances in Cutaneous and Basal Cell Carcinoma

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

More News

AI Chip | Image credit: Shuo - stock.adobe.come
March 16th 2024

Federated Learning Models Show Potential in Melanoma-Nevus Classification, but Improvements Needed

Kyle Munz
A multicentric, single-arm diagnostic study created a decentralized federated learning model for the classification of invasive melanomas and nevi, showcasing comparable results to centralized data models.
Woman Checking Skin for Signs of Melanoma | image credit: MW Photography - stock.adobe.com
March 14th 2024

Use of Immunohistochemistry in Melanoma Diagnosis Has Grown, but More Research Is Needed

Kyle Munz
A retrospective, cross-sectional study analyzed national trends of immunohistochemistry (IHC) use in the diagnosis of melanoma.
Guidelines Spelled in Blocks | image credit: chrupka - stock.adobe.com
March 8th 2024

More Research Needed to Address Discordance in Skin Cancer Treatment Guidelines

Kyle Munz
A comparative analysis on skin cancer management guidelines in the US highlights the necessity of further research in this subject.
Melanoma on Skin | image credit: Ocskay Mark - stock.adobe.com
February 29th 2024

Skin Cancer Overdiagnosis in White Americans Is Increasing, Study Says

Kyle Munz
An ecological study revealed increasing rates of skin cancer overdiagnosis in white Americans.
AI Display Concept | image credit: Tierney - stock.adobe.com
February 21st 2024

Skin Cancer Treatment Landscape Is Evolving With AI

Kyle Munz
Andrew Ress, MD, discusses the novel integration of artificial intelligence (AI) into the skin cancer treatment landscape.
Preventative Melanoma Screening | image credit: sofiko14
February 13th 2024

Clinical Data Lacking on Black Patients With Melanoma

Kyle Munz
A single-institution, retrospective cohort study evaluates knowledge gaps in clinical data on Black patients with melanoma.
Genome Sequencing Model | image credit: catalin - stock.adobe.com
February 7th 2024

Predisposition to Early-Onset Merkel Cell Carcinoma Linked to Genetic Variants

Kyle Munz
A case-control study found that patients with early-onset Merkel cell carcinoma exhibited genetic variations associated with the development of their disease.
Clinician Performing Skin Examination | image credit: Peakstock - stock.adobe.com
February 6th 2024

Stigma, Discrimination Impact Sexual and Gender Minority Perspectives on Full-Body Skin Examinations, Study Finds

Kyle Munz
A survey revealed the influence of prior stigmatic or discriminatory experiences on sexual and gender minority (SGM) patients’ perceptions of screening for skin cancer, stressing the need for affirming clinical settings.
Piggy Bank With Stethoscope | image credit: Nudphon - stock.adobe.com
February 1st 2024

40-GEP Test Utilization Can Mitigate Financial Burden of Cutaneous Squamous Cell Carcinoma

Kyle Munz
Medicare-eligible patients with cutaneous squamous cell carcinoma (cSCC) could save on health care costs by utilizing the 40-gene expression profile (40-GEP) to guide treatment decisions.
Hair Color Spectrum | image credit: Elvira - stock.adobe.com
January 23rd 2024

Natural Hair Color Identified as Potential Skin Cancer Risk Factor

Kyle Munz
Results from a meta-analysis suggest a correlation between natural hair color and the development of skin cancer.
Skin Examination | image credit: thodonal - stock.adobe.come
January 18th 2024

Phase 3 Data Show Long-Term Survival Benefit of Tebentafusp in Metastatic Uveal Melanoma

Kyle Munz
An international, open-label trial demonstrated the overall survival benefits of administering tebentafusp to HLA-A*02:01-positive patients with metastatic uveal melanoma.
what we're reading logo
January 18th 2024

What We’re Reading: New Prior Authorization Limits; Veteran Suicide Prevention Program; AI Skin Cancer Detector

AJMC Staff
CMS has announced new federal rules that require health insurers to streamline requests to cover treatments; nearly 50,000 veterans used the emergency suicide prevention program launched by the Department of Veteran Affairs in 2023; the FDA recently authorized the first artificial intelligence (AI)-powered medical device to help doctors detect the most common forms of skin cancer.
Ultraviolet Light Model | image credit: Sergey Ryzhov - stock.adobe.com
January 12th 2024

Ultraviolet Phototherapy Without Psoralens Does Not Increase Risk of Skin Cancer, Study Suggests

Kyle Munz
A retrospective cohort study found no significant associations between phototherapy without psoralens and the risk of skin cancer.
Melanoma on Skin | Image credit: Ocskay Mark - stock.adobe.com
January 11th 2024

Patients With Regressive Melanoma Eligible for Sentinel Lymph Node Biopsy May Have Better Outcomes

Kyle Munz
A single-institutional cohort study found that in patients with melanoma, regressive status could be used as a valuable predictive marker of prognosis and response to systemic therapy.
Portrait of Native American Women | image credit: Gary - stock.adobe.com
January 9th 2024

Skin Cancer’s Impact on American Indian/Alaska Native Communities Deserves More Consideration

Kyle Munz
A retrospective study showcases the need for considering the impact of skin cancers in non-Hispanic American Indian/Alaska Native communities, who experience some of the highest incidences of melanoma in the US.
Actinic Keratosis Text Concept | image credit: Anar Mammadov - stock.adobe.com
January 6th 2024

Actinic Keratoses Put Patients at Increased Skin Cancer Risk

Kyle Munz
This retrospective cohort study demonstrates the heightened risks individuals with actinic keratoses have for developing skin cancers.
Graphic representing the top 5 skin cancer articles for 2022
December 23rd 2022

Top 5 Most-Read Skin Cancer Articles of 2022

Maggie L. Shaw
BRAF mutations were addressed in depth this year, having been mentioned in 3 of this year’s top 5 articles. Also discussed were a first-in-its-class combination treatment approval and potential indicators of increased skin cancer risk.
Image of researchers investigating for skin cancer
December 21st 2022

Novel, Nonsurgical BCC Treatment Shown Safe and Effective

Maggie L. Shaw
In this study, researchers treated 37 basal cell carcinoma (BCC) lesions from 30 patients, with follow-ups at 5 time points after baseline examination.
What We're Reading
December 14th 2022

What We’re Reading: mRNA Vaccine Effective Against Melanoma; Proposed Addiction Treatment Policy; Maternal Health Disparities Before Abortion Bans

AJMC Staff
Moderna’s mRNA-4157/V940 combined with Merck’s pembrolizumab reduced melanoma recurrence and death; HHS proposed permanently implementing emergency opioid use disorder policies enacted in 2020; maternal death rates were 62% higher in 2020 in states that now have abortion restrictions.
Abstract image of clinical data
December 10th 2022

Real-world Data Demonstrate Strength, Durability of Checkpoint Inhibitor Use in cSCC

Maggie L. Shaw
Response, progression-free survival, overall survival, time-to-next-treatment, and toxicity outcomes were evaluated among patients with advanced cutaneous squamous cell carcinoma (cSCC) who received first-line treatment with immune checkpoint inhibitors.
Image of examination for skin cancer
November 29th 2022

Lack of Knowledge Continues to Influence Delayed Melanoma Diagnosis

Maggie L. Shaw
Malignant cutaneous melanoma outcomes were investigated as they relate to diagnosis delay and potential influence from socioeconomic and demographic factors in Brazil, where skin cancer diagnoses represent 30% of all cancer diagnoses.
Image of a transplant surgery
November 24th 2022

Risk of Subsequent Skin Cancer Seen Among Organ Transplant Recipients

Maggie L. Shaw
The study's goal was to clarify possible second and third skin cancer development patterns among organ transplant recipients who developed more than 1 instance of skin cancer and to better characterize this patient population by patient age and transplanted organ type.
Close-up image of face
November 16th 2022

Cryosurgery Effective Against BCC Relapse, but Further Study Required

Maggie L. Shaw
While immunocryosurgery is known to be effective against primary nonsuperficial basal cell carcinoma (BCC), there is less data on its effectiveness in relapsed BCC.
Image of melanoma
November 10th 2022

Revised Classification Criteria Needed Due to Melanoma Overdiagnosis

Maggie L. Shaw
The increasing rate of melanoma diagnosis may not be due to actual disease, the authors of a new study posit; instead, it may be due to overdiagnosis of patients with an actual very low risk of death.
Image of the human body and some organs
October 27th 2022

Organ Transplant Patients at Higher Risk of BCC vs the General Population

Maggie L. Shaw
This investigation compared the histologic features of basal cell carcinoma (BCC) between organ transplant recipients and the general population.
Image of cancer-genetics link
October 22nd 2022

Neurofibromatosis Type 1 Linked to Greater Skin Cancer Risk

Maggie L. Shaw
The risks of 4 types of skin cancers were investigated among patients who have neurofibromatosis type 1, a multisystem autosomal dominant genetic syndrome characterized by loss of neurofibromin.
Dermatologist using a dermatoscope
October 11th 2022

Review Finds Dermoscopy Can Reduce Incomplete Excision of Skin Cancer

Mary Caffrey
Dermoscopy is a relatively inexpensive and readily available tool that can improve outcomes and quality of life for patients who need surgical excision of nonmelanoma skin cancers, the authors found.
Image of a doctor examining a patient's neck
October 7th 2022

Certain Patients Who Have BCC May Benefit From Electrochemotherapy

Maggie L. Shaw
Electrochemotherapy in basal cell carcinoma (BCC) was evaluated for its utilization practicality, efficacy, and safety, as well as factors that may predict disease response to the treatment.
Image of basal cell carcinoma
September 30th 2022

Advanced Imaging System Investigated for Faster Diagnosis of Skin Cancers

Maggie L. Shaw
This new study explored the diagnostic utility and accuracy of 2-photon fluorescence microscopy (TPFM) among nonmelanoma skin cancers, which included basal cell carcinoma and squamous cell carcinoma.
Examining for skin cancer
September 27th 2022

Postsurgical Positive Margins Top Indicator of BCC Recurrence

Maggie L. Shaw
This new study investigated risk factors for basal cell carcinoma (BCC) recurrence in the head and neck region.
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