Skin Cancer

The AJMC® Skin Cancer compendium is a comprehensive resource for clinical news and expert insights about melanoma and other skin cancers.

Latest News

Patients in the cemiplimab group had superior disease-free survival vs placebo. | Image credit: Medical Works - stock.adobe.com
Cemiplimab Improves Disease-Free Survival in High-Risk, Advanced CSCC

June 13th 2025

Cemiplimab improved disease-free survival in patients with high-risk cutaneous squamous cell carcinoma (CSCC) and performed well in patients with advanced CSCC in the real-world setting.

The approval covers use of pembrolizumab as a single agent in the neoadjuvant setting, followed by adjuvant treatment with pembrolizumab in combination with radiotherapy with or without cisplatin after surgery, and then continued as a single agent. | Image credit: wladimir1804-stock.adobe.com
FDA Approves Perioperative Pembrolizumab in Resectable HNSCC

June 13th 2025

The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com
C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

June 7th 2025

skin cancer screening doctor - Seventyfour - stock.adobe.com
Global Skin Cancer Burden Among Older Adults Surged Since 1990, Driven by Keratinocyte Cancer

May 21st 2025

Future validation studies with a larger sample size are warranted to ensure the technique will be useful in a clinical setting. | Image credit: Artur Wnorowski - stock.adobe.com
Novel, Noninvasive Skin Cancer Detection Method Shows Promise

May 18th 2025

Dr. Jason Luke leads a panel discussing immunotherapy advances in Cutaneous and Basal Cell Carcinoma

Watch the series now!

Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

More News

Skin cancer check | Image credit: InsideCreativeHouse - stock.adobe.com
April 30th 2024

Survivors of Early-Stage Melanoma Have High Rates of Fear of Recurrence, Study Finds

Rose McNulty
The study aimed to improve the understanding of lived experiences and the fear of recurrence among survivors of localized, stage 0 to IIA cutaneous melanoma.
Skin Check for Melanoma | image credit: cunaplus - stock.adobe.com
April 26th 2024

Exploration of Melanoma Incidence, Mortality Rates Urges Further Research

Kyle Munz
A retrospective analysis out of Denmark could not find a causal relationship to explain trends in melanoma incidence and mortality rates, demonstrating the need for more research in this area.
AI-Generated CT Equipment Concept | image credit: StraSyP - stock.adobe.com
April 15th 2024

Dr Michael Farwell on FDG PET/CT Imaging to Predict Immunotherapy Response in Advanced Melanoma

Kyle Munz
Michael Farwell, MD, associate professor of radiology at the Hospital of the University of Pennsylvania, provides insights into a study on the benefits of using 18F-fluorodeoxyglucose (FDG) PET/CT imaging to detect metabolic tumor changes in skin cancer.
AI-Based Smartphone App Proves Reliable in Diagnosis of Melanoma
April 9th 2024

AI-Based Smartphone App Proves Reliable in Diagnosis of Melanoma

Kyle Munz
A prospective study evaluating the efficacy of an artificial intelligence (AI)–based clinical support system further demonstrated the reliability of AI or machine learning as a diagnostic tool in skin cancer.
Cancerous Cells Concept | image credit: Dr_Microbe - stock.adobe.com
April 5th 2024

Yes-Associated Protein May Hold Prognostic Value in Cutaneous Melanoma

Kyle Munz
A retrospective study analyzing tissue assays from patients with cutaneous melanoma demonstrated the promise of yes-associated protein (YAP) as a predictive biomarker for melanoma prognosis.
Collaboration With AI Concept | image credit: ipopba - stock.adobe.com
March 30th 2024

AI Accurately Predicts Skin Cancer Risk Based on 2D Facial Images

Kyle Munz
An artificial intelligence (AI) mode was more accurate in assessing patient risks for skin cancer through the analysis of 2D facial images compared with more traditional risk-factor screening.
Man Prior to Skin Examination | image credit: New Africa - stock.adobe.com
March 28th 2024

Risk for Second Primary Melanoma Increases After Primary Melanoma Diagnosis as Men Age

Kyle Munz
A population-based cohort study out of Norway has found that older men have a higher risk of developing second primary invasive melanoma following an initial primary melanoma, suggesting the benefits of increased surveillance in these patients.
Radiation Therapy Model | image credit: Andrii - stock.adobe.com
March 26th 2024

Radiation Therapy Associated With Elevated Skin Cancer Risk in Patients With Breast Cancer

Kyle Munz
Results from a retrospective cohort study analyzing patients with breast cancer bolster reports of an association between radiation therapy and subsequent risks of skin cancers.
AI Chip | Image credit: Shuo - stock.adobe.come
March 16th 2024

Federated Learning Models Show Potential in Melanoma-Nevus Classification, but Improvements Needed

Kyle Munz
A multicentric, single-arm diagnostic study created a decentralized federated learning model for the classification of invasive melanomas and nevi, showcasing comparable results to centralized data models.
Woman Checking Skin for Signs of Melanoma | image credit: MW Photography - stock.adobe.com
March 14th 2024

Use of Immunohistochemistry in Melanoma Diagnosis Has Grown, but More Research Is Needed

Kyle Munz
A retrospective, cross-sectional study analyzed national trends of immunohistochemistry (IHC) use in the diagnosis of melanoma.
Guidelines Spelled in Blocks | image credit: chrupka - stock.adobe.com
March 8th 2024

More Research Needed to Address Discordance in Skin Cancer Treatment Guidelines

Kyle Munz
A comparative analysis on skin cancer management guidelines in the US highlights the necessity of further research in this subject.
Melanoma on Skin | image credit: Ocskay Mark - stock.adobe.com
February 29th 2024

Skin Cancer Overdiagnosis in White Americans Is Increasing, Study Says

Kyle Munz
An ecological study revealed increasing rates of skin cancer overdiagnosis in white Americans.
AI Display Concept | image credit: Tierney - stock.adobe.com
February 21st 2024

Skin Cancer Treatment Landscape Is Evolving With AI

Kyle Munz
Andrew Ress, MD, discusses the novel integration of artificial intelligence (AI) into the skin cancer treatment landscape.
Preventative Melanoma Screening | image credit: sofiko14
February 13th 2024

Clinical Data Lacking on Black Patients With Melanoma

Kyle Munz
A single-institution, retrospective cohort study evaluates knowledge gaps in clinical data on Black patients with melanoma.
Genome Sequencing Model | image credit: catalin - stock.adobe.com
February 7th 2024

Predisposition to Early-Onset Merkel Cell Carcinoma Linked to Genetic Variants

Kyle Munz
A case-control study found that patients with early-onset Merkel cell carcinoma exhibited genetic variations associated with the development of their disease.
Clinician Performing Skin Examination | image credit: Peakstock - stock.adobe.com
February 6th 2024

Stigma, Discrimination Impact Sexual and Gender Minority Perspectives on Full-Body Skin Examinations, Study Finds

Kyle Munz
A survey revealed the influence of prior stigmatic or discriminatory experiences on sexual and gender minority (SGM) patients’ perceptions of screening for skin cancer, stressing the need for affirming clinical settings.
Piggy Bank With Stethoscope | image credit: Nudphon - stock.adobe.com
February 1st 2024

40-GEP Test Utilization Can Mitigate Financial Burden of Cutaneous Squamous Cell Carcinoma

Kyle Munz
Medicare-eligible patients with cutaneous squamous cell carcinoma (cSCC) could save on health care costs by utilizing the 40-gene expression profile (40-GEP) to guide treatment decisions.
Hair Color Spectrum | image credit: Elvira - stock.adobe.com
January 23rd 2024

Natural Hair Color Identified as Potential Skin Cancer Risk Factor

Kyle Munz
Results from a meta-analysis suggest a correlation between natural hair color and the development of skin cancer.
Skin Examination | image credit: thodonal - stock.adobe.come
January 18th 2024

Phase 3 Data Show Long-Term Survival Benefit of Tebentafusp in Metastatic Uveal Melanoma

Kyle Munz
An international, open-label trial demonstrated the overall survival benefits of administering tebentafusp to HLA-A*02:01-positive patients with metastatic uveal melanoma.
what we're reading logo
January 18th 2024

What We’re Reading: New Prior Authorization Limits; Veteran Suicide Prevention Program; AI Skin Cancer Detector

AJMC Staff
CMS has announced new federal rules that require health insurers to streamline requests to cover treatments; nearly 50,000 veterans used the emergency suicide prevention program launched by the Department of Veteran Affairs in 2023; the FDA recently authorized the first artificial intelligence (AI)-powered medical device to help doctors detect the most common forms of skin cancer.
Ultraviolet Light Model | image credit: Sergey Ryzhov - stock.adobe.com
January 12th 2024

Ultraviolet Phototherapy Without Psoralens Does Not Increase Risk of Skin Cancer, Study Suggests

Kyle Munz
A retrospective cohort study found no significant associations between phototherapy without psoralens and the risk of skin cancer.
Melanoma on Skin | Image credit: Ocskay Mark - stock.adobe.com
January 11th 2024

Patients With Regressive Melanoma Eligible for Sentinel Lymph Node Biopsy May Have Better Outcomes

Kyle Munz
A single-institutional cohort study found that in patients with melanoma, regressive status could be used as a valuable predictive marker of prognosis and response to systemic therapy.
Portrait of Native American Women | image credit: Gary - stock.adobe.com
January 9th 2024

Skin Cancer’s Impact on American Indian/Alaska Native Communities Deserves More Consideration

Kyle Munz
A retrospective study showcases the need for considering the impact of skin cancers in non-Hispanic American Indian/Alaska Native communities, who experience some of the highest incidences of melanoma in the US.
Actinic Keratosis Text Concept | image credit: Anar Mammadov - stock.adobe.com
January 6th 2024

Actinic Keratoses Put Patients at Increased Skin Cancer Risk

Kyle Munz
This retrospective cohort study demonstrates the heightened risks individuals with actinic keratoses have for developing skin cancers.
Graphic representing the top 5 skin cancer articles for 2022
December 23rd 2022

Top 5 Most-Read Skin Cancer Articles of 2022

Maggie L. Shaw
BRAF mutations were addressed in depth this year, having been mentioned in 3 of this year’s top 5 articles. Also discussed were a first-in-its-class combination treatment approval and potential indicators of increased skin cancer risk.
Image of researchers investigating for skin cancer
December 21st 2022

Novel, Nonsurgical BCC Treatment Shown Safe and Effective

Maggie L. Shaw
In this study, researchers treated 37 basal cell carcinoma (BCC) lesions from 30 patients, with follow-ups at 5 time points after baseline examination.
What We're Reading
December 14th 2022

What We’re Reading: mRNA Vaccine Effective Against Melanoma; Proposed Addiction Treatment Policy; Maternal Health Disparities Before Abortion Bans

AJMC Staff
Moderna’s mRNA-4157/V940 combined with Merck’s pembrolizumab reduced melanoma recurrence and death; HHS proposed permanently implementing emergency opioid use disorder policies enacted in 2020; maternal death rates were 62% higher in 2020 in states that now have abortion restrictions.
Abstract image of clinical data
December 10th 2022

Real-world Data Demonstrate Strength, Durability of Checkpoint Inhibitor Use in cSCC

Maggie L. Shaw
Response, progression-free survival, overall survival, time-to-next-treatment, and toxicity outcomes were evaluated among patients with advanced cutaneous squamous cell carcinoma (cSCC) who received first-line treatment with immune checkpoint inhibitors.
Image of examination for skin cancer
November 29th 2022

Lack of Knowledge Continues to Influence Delayed Melanoma Diagnosis

Maggie L. Shaw
Malignant cutaneous melanoma outcomes were investigated as they relate to diagnosis delay and potential influence from socioeconomic and demographic factors in Brazil, where skin cancer diagnoses represent 30% of all cancer diagnoses.
Image of a transplant surgery
November 24th 2022

Risk of Subsequent Skin Cancer Seen Among Organ Transplant Recipients

Maggie L. Shaw
The study's goal was to clarify possible second and third skin cancer development patterns among organ transplant recipients who developed more than 1 instance of skin cancer and to better characterize this patient population by patient age and transplanted organ type.
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